Inhibition of Gastrin and Gastric-Acid Secretion by Growth-Hormone Release-Inhibiting Hormone

The effect of the peroxisome proliferator ciprofibrate on the gastric mucosa and particularly the gastrin cell

“…The release of gastrin from the G cell is normally stimulated by proteins in the food (Lichtenberger 1982), and inhibited by gastric acidity (Walsh et al 1975). The vagal nerves also stimulate gastrin release via gastrin releasing peptide (GRP) (Holst et al 1987) whereas somatostatin inhibits gastrin release (Bloom et al 1974). We have previously shown that ciprofibrate, contrary to a previous report (Eason et al 1988a), does not inhibit gastric acid secretion (Martinsen et al 1996).…”

Octreotide Decreases Biliary and Pancreatic Exocrine Function, and Induces Steatorrhea in Healthy Subjects.

“…and exerts its physiological actions as a paracrine, endocrine, and neurotransmitter ( 1 ). Its principal effects on the target organ are the inhibition of gastrointestinal hormone functions (2)(3)(4)(5), as well as the inhibition of the secretion of gastrointestinal hormones themselves, such as gastrin, cholecystokinin-pancreozymin (PZ), and secretin (6)(7)(8). Somatostatinoma, which produces somatostatin, is very frequently complicated with cholelithiasis and steatorrhea (9).…”

Elucidating the Role of Disulfide Bond on Amyloid Formation and Fibril Reversibility of Somatostatin-14

“…Somatostatin-14 (SST- 14) 4 is a small cyclic peptide hormone secreted by hypothalamus, one of the well known functions of which is to inhibit the release of growth hormone (16). Other important functions of somatostatin-14 include inhibition of gastrin and gastric acid secretion, inhibition of insulin and glucagon secretion in pancreas, and regulation of amyloid-␤ peptide, A␤42, in brain (17)(18)(19) Somatostatin-14 has previously been reported to form amyloid fibrils in vitro (4,20). In this study, we first show that somatostatin-14 is stored as amyloid-like aggregates in rat hypothalamus tissues (Fig.…”