Inhibition of gluconeogenesis and p -aminohipuric acid accumulation in rat renal cortical slices by ionic and nonionic contrast media

Nakamura, Motonobu; Uozumi, Jiro; Soejima, Kyoko; Kanou, Takehiro; Tokuda, Noriaki; Naito, Seiji

doi:10.1007/s10157-002-0221-z

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…Asterisk indicates a statistically significant difference (P Ͻ 0.05) between two drugs, as assessed by Tukey HSD test. NS indicates no significant difference statistically The asterisks indicate a statistically significant difference from the control, with a P value of 0.05 (Dunnett's test) Data values are expressed as the mean values Ϯ SD of five rats heavy metals (Smith 9 ), platinum complex anticancer agents (Kameyama et al, 5 Uozumi et al 6 ), and contrast media containing iodine (Wasaki et al, 11 Uozumi et al, 12 Soejima et al, 8 Nakamura et al 7 ) have been examined using this experimental system. In this study, we examined the effects of oxaliplatin, a new platinum complex anticancer agent, on functions such as the PAH transport activity and the gluconeogenesis activity of tubular epithelial cells, and we compared these effects with the effects of cisplatin and carboplatin.…”

Section: Discussionmentioning

confidence: 99%

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Experimental study of renal disorder caused by oxaliplatin in rat renal cortical slices

Kanou¹,

Uozumi

Soejima

et al. 2004

Clin Exp Nephrol

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Section: Discussionmentioning

confidence: 99%

“…Renal slices were incubated with various concentrations of each of the platinum-containing drugs for 120 min. These experimental conditions were determined based on previous reports (Kameyama et al, 5 Uozumi et al, 6 Nakamura et al, 7 Soejima et al 8 ).…”

Section: Methodsmentioning

confidence: 99%

Experimental study of renal disorder caused by oxaliplatin in rat renal cortical slices

Kanou¹,

Uozumi

Soejima

et al. 2004

Clin Exp Nephrol

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“…Due to this incompatibility with the polymeric matrix, the contrast forms a segregated phase and makes mixing of reagents more difficult during the preparation. For this reason, some authors have suggested the use of alternative contrasts, such as iodine (Almén, 1995;Davy et al, 1997;Davenport et al, 1999;Ginebra et al, 2002;Nakamura et al, 2003;Artola et al, 2004;Kjellson et al, 2004;Van Hooy-Corstjensa et al, 2004) and/or bismuth (Rawls et al, 1996;Deb et al, 2002) based compounds. These compounds are chemically linked to specially designed monomers and are thus automatically incorporated into the BC formulation.…”

Section: Verified That It Is Verymentioning

confidence: 99%

Production of bone cement composites: effect of fillers, co-monomer and particles properties

Santos¹,

Pita²,

Melo³

et al. 2011

Braz. J. Chem. Eng.

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-Artificial bone cements (BCs) based on poly(methyl methacrylate) (PMMA) powders and methyl methacrylate (MMA) liquid monomer also present in their formulation small amounts of other substances, including a chemical initiator compound and radiopaque agents. Because inadequate mixing of the recipe components during the manufacture of the bone cement may compromise the mechanical properties of the final pieces, new techniques to incorporate the fillers into the BC and their effect upon the mechanical properties of BC pieces were investigated in the present study. PMMA powder composites were produced insitu in the reaction vessel by addition of X-ray contrasts to the reacting MMA mixture. It is shown that this can lead to much better mechanical properties of test pieces, when compared to standard bone cement formulations, because enhanced dispersion of the radiopaque agents can be achieved. Moreover, it is shown that the addition of hydroxyapatite (HA) and acrylic acid (AA) to the bone cement recipe can be beneficial for the mechanical performance of the final material. It is also shown that particle morphology can exert a tremendous effect upon the performance of test pieces, indicating that the suspension polymerization step should be carefully controlled when optimization of the bone cement formulation is desired.

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“…Iodixanol (IDX) and iohexol (IHX) are non-ionic monomers and dimers, respectively, containing iodine, and were originally developed as water-soluble contrast media to be used in radiographic investigations such as angiography (Almén 1995). Since then, they have been used in millions of investigations annually worldwide with minimal side effects (Davenport et al 1999;Nakamura 2003). Both these contrast media have now been produced as fine ground powder, which is mixed in with the powder phase of bone cement prior to cement polymerization.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo biological responses to a novel radiopacifying agent for bone cement

Wang

Diaz

Sabokbar

et al. 2005

J. R. Soc. Interface.

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Iodixanol (IDX) and iohexol (IHX) have been investigated as possible radiopacification agents for polymethylmethacrylate (PMMA) bone cement, to replace the currently used barium sulphate and zirconia. IDX and IHX are both water-soluble iodine-based contrast media and for the last 20 years have been used extensively in clinical diagnostic procedures such as contrast media enhanced computed tomography, angiography and urography. One of the major reasons to remove the current radiopacifying agents is their well-documented cytotoxicity and their potential to increase bone resorption.Using in vitro bone resorption assays, the effect of PMMA particles plus IDX or IHX to induce osteoclast formation and lacunar resorption on dentine slices has been investigated. These responses have been compared with the in vitro response to PMMA particles containing the conventional radiopacifying agents, that is, barium sulphate and zirconia. In parallel, the in vivo reaction, in terms of new bone formation, to particles of these materials has been tested using a bone harvest chamber in rabbit tibiae.In vitro cell culture showed that PMMA containing IHX resulted in significantly less bone resorption than PMMA containing the conventional opacifiers. In vivo testing, however, showed no significant differences between the amounts of new bone formed around cement samples containing the two iodine-based opacifying agents in particulate form, although both led to fewer inflammatory cells than particles of PMMA containing zirconia. Our results suggest that a non-ionic radiopacifier could be considered as an alternative to the conventional radiopacifying agents used in biomaterials in orthopaedic surgery.

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Inhibition of gluconeogenesis and p -aminohipuric acid accumulation in rat renal cortical slices by ionic and nonionic contrast media

Abstract: Nonionic CM is less nephrotoxic than ionic CM with regard to gluconeogenesis and PAH accumulation in rat renal slices. These differences in nephrotoxic effect between ionic and nonionic CM may in part be attributable to differences in osmotic pressure.

Cited by 4 publications

References 20 publications

Experimental study of renal disorder caused by oxaliplatin in rat renal cortical slices

Experimental study of renal disorder caused by oxaliplatin in rat renal cortical slices

Production of bone cement composites: effect of fillers, co-monomer and particles properties

In vitro and in vivo biological responses to a novel radiopacifying agent for bone cement

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