Inhibition of Glucose Utilization in Isolated Rat Soleus Muscle by Pseudouridine: Implications for Renal Failure

Dzúrik, R; Spustová, Viera; Lajdova, Ingrid

doi:10.1159/000187450

Cited by 36 publications

(19 citation statements)

References 13 publications

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“…Insulin resistance, associated with hyperinsulinemia, has been extensively studied in ESRD, and several pathogenic factors underlying insulin resistance in ESRD have been proposed, as follows: (1) impaired glucose uptake 2 and glucose transport in uremic muscle, 20 (2) defects in the intracellular pathways of glucose metabolism, 20 (3) abnormalities in oxidative and non-oxidative glucose metabolism, 21 (4) elevated circulating concentrations of FFA and hormones with antagonistic actions on insulin, such as glucagon and growth hormone, and (5) an accumulation of uremic toxins. 22 Although the causes of impaired glucose tolerance (IGT) in this patient might include the above-mentioned factors, we found that anemia was a major pathogenic factor behind her insulin resistance, which is in accordance with the findings of Borissova et al 23 and Mak. 24,25 These studies [23][24][25] showed that insulinstimulated glucose disposal increased by about 50% in HD patients after the correction of anemia by treatment with erythropoietin for 3 to 9 months, by assessment of insulin sensitivity with a hyperinsulinemic euglycemic clamp.…”

Section: Discussionsupporting

confidence: 92%

The beneficial effect of effective control of anemia on hyperinsulinemia and hypoxemia in a hemodialysis patient with corrected transposition of the great arteries

et al. 2004

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We report the beneficial effect of control of anemia on hyperinsulinemia and hypoxemia in a hemodialysis patient with corrected transposition of the great arteries. The patient's hemoglobin (Hb) level of 10.3 g/dl on admission represents good control for hemodialysis (HD) patients, but it was too low for this patient with secondary polycythemia because of a right-to-left shunt. Control of anemia for a 10-month period was followed by a marked increase in Hb level (from 10.3 g/dl to 13.9 g/dl) and in aerobic work capacity, while the fasted insulin level decreased from 36.7 microU/ml to 8.0 microU/ml, without changes in leptin level, body mass index (BMI), fat mass, Kt/V, or protein catabolic rate (PCR). Additionally, hypoxemia was ameliorated, from PO2 33.1 mmHg to PO2 56.2 mmHg, and the hyperdynamic cardiac state was improved. The degree of anemia, together with deteriorating tissue oxygenation, may have predisposed this patient to developing insulin resistance and consequent hyperinsulinemia. The most appropriate target Hb concentration should be tailored for the clinical condition of each individual patient, bearing in mind an insulin-resistance state, especially in hemodialysis patients with hypoxemia. A more complete understanding of what regulates insulin resistance and consequent hyperinsulinemia in endstage renal disease (ESRD) awaits the elucidation of carbohydrate and insulin metabolism.

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Section: Discussionsupporting

confidence: 92%

The beneficial effect of effective control of anemia on hyperinsulinemia and hypoxemia in a hemodialysis patient with corrected transposition of the great arteries

et al. 2004

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“…Pseudouridine, an outstanding nucleoside, which is not rebuilt into the tRNA once the parent tRNA is broken down, is another accused factor. Pseudouridine inhibits glucose utilization at the postreceptor level through lowering the intracellular Ca concentration [29] . A nonspecific binding reaction between cyanic acid formed from urea and protein or peptide is called carbamoylation.…”

Section: Retention Of Nitrogenous Compoundsmentioning

confidence: 99%

Evidence for Increased Risk of Prediabetes in the Uremic Patient

Shehab-Eldin¹,

Ragheb²,

Klassen³

et al. 2007

Nephron Clin Pract

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A prediabetic state is defined as a higher than normal blood glucose level but not yet high enough to meet the diagnosis of overt diabetes mellitus. While patients with advanced diabetic nephropathy are vulnerable to hypoglycemia, we believe that there is sufficient evidence that uremic nondiabetic patients are susceptible to hyperglycemia, which calls for more attention that uremia is a prediabetic state. It is, therefore, intriguing to identify these uremic factors which lead to prediabetes. Such a study may have significance to improve uremic patients’ outcomes. To raise the awareness of the uremic prediabetic state, this review will, therefore, elaborate on the analysis of factors important in the development of prediabetes in uremia and will delineate whether their modification leads to an improved patient outcome.

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“…IR did not increase with decreasing kidney function. Of course, this would change in the case of further reduction of kidney function because of accumulation of glucose utilization inhibitors, such as hippurate [18] or pseudouridine [11] accumulating mark edly if the clearance of endogenous creatinine decreased below 0.50 ml/s [11,18] and inhibiting insulin action at the insulin postreceptor level [19,20], Their accumula tion could explain the increased IR just in advanced renal failure. Thus, the participation of other mechanisms could have been suggested in mildly to moderately de creased kidney function.…”

Section: Insulin Resistancementioning

confidence: 99%

The Prevalence of Insulin Resistance in Kidney Disease Patients before the Development of Renal Failure

Dzúrik

Spustová

1995

Nephron

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Patients with advanced renal failure suffer from almost constant insulin resistance (IR) which is a major risk factor of atherosclerosis and very probably also of glomemlosclerosis. However, data on IR in kidney disease patients with mild-to-moderate kidney function decrease are lacking. A group of 52 patients with various kidney diseases and decreased kidney function of different degree but not with advanced renal failure was evaluated. Almost half of them suffered from IR though they did not differ from insulin-sensitive patients in age, sex, prevalence of various kidney diseases, hypertension, clearance of endogenous creatinine, serum creatinine, urea, uric acid, hippurate or pseudouridine concentrations. They did not differ in the prevalence and degree of metabolic acidosis or in the concentration of plasma and total and free magnesium in erythrocytes. They were just slightly more obese and their serum TG and VLDL concentrations were increased and HDL concentration decreased. It is concluded that IR and dyslipoproteinemia develop in the early stages of kidney diseases and could participate in kidney disease progression since the beginning of kidney disease. It is suggested that early treatment of these alterations could decrease the progression of kidney disease more effectively than their treatment in advanced stages.

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Inhibition of Glucose Utilization in Isolated Rat Soleus Muscle by Pseudouridine: Implications for Renal Failure

Cited by 36 publications

References 13 publications

The beneficial effect of effective control of anemia on hyperinsulinemia and hypoxemia in a hemodialysis patient with corrected transposition of the great arteries

The beneficial effect of effective control of anemia on hyperinsulinemia and hypoxemia in a hemodialysis patient with corrected transposition of the great arteries

Evidence for Increased Risk of Prediabetes in the Uremic Patient

The Prevalence of Insulin Resistance in Kidney Disease Patients before the Development of Renal Failure

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