Inhibition of hepatic gluconeogenesis by phenethylhydrazine (phenelzine)

Kleineke, Jochen; Peters, H. C.; Ling, Hongzhi

doi:10.1016/0006-2952(79)90441-6

Cited by 13 publications

(2 citation statements)

References 28 publications

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“…As indicated above, the non-selective MAO inhibitor phenelzine is also an SSAO inhibitor [10]. In addition, owing to its hydrazine structure and not to MAOI considerations, phenelzine has been reported to induce hypoglycaemia in animal models and in depressed patients through the impairment of gluconeogenesis, likely as a consequence of phosphoenolpyruvatecarboxykinase (PEPCK) inhibition [47]. Since phenelzine is an old drug prescribed for antidepressant therapy, with no clear evidence of the serious adverse effects attributed to hydrazines as discussed above, it is a good candidate for drug repositioning.…”

Section: Combining the Inhibition Effect Of Maos And Aocs On Adipomentioning

confidence: 99%

Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors

et al. 2019

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Background: Two classes of amine oxidases are found in mammals: those with a flavin adenine dinucleotide as a cofactor, such as monoamine oxidases (MAO) and lysine-specific demethylases (LSD), and those with copper as a cofactor, including copper-containing amine oxidases (AOC) and lysyl oxidases (LOX). All are expressed in adipose tissue, including a semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) strongly present on the adipocyte surface. Methods: Previously, irreversible MAO inhibitors have been reported to limit food intake and/or fat extension in rodents; however, their use for the treatment of depressed patients has not revealed a clear anti-obesity action. Semicarbazide and other molecules inhibiting SSAO/VAP-1 also reduce adiposity in obese rodents. Results: Recently, a LOX inhibitor and a subtype-selective MAO inhibitor have been shown to limit fattening in high-fat diet-fed rats. Phenelzine, which inhibits MAO and AOC, limits adipogenesis in cultured preadipocytes and impairs lipogenesis in mature adipocytes. When tested in rats or mice, phenelzine reduces food intake and/or fat accumulation without cardiac adverse effects. Novel amine oxidase inhibitors have been recently characterized in a quest for promising anti-inflammatory or anti-cancer approaches; however, their capacity to mitigate obesity has not been studied so far. Conclusions: The present review of the diverse effects of amine oxidase inhibitors impairing adipocyte differentiation or limiting excessive fat accumulation indicates that further studies are needed to reveal their potential anti-obesity properties.

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Section: Combining the Inhibition Effect Of Maos And Aocs On Adipomentioning

confidence: 99%

Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors

et al. 2019

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“…In addition, an overdose can lead to fainting, excessive sweating, a rapid pulse, and shallow breathing. 6,7 Moreover, PZ has a toxic reaction in the liver, leading to liver damage. Alternatively, propofol (PPF) is a short-acting intravenous anaesthetic used for the induction and maintenance of general anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

Configuration-regulated highly luminescent hydrogen–organic frameworks for detection of phenelzine and propofol

Liu,

Yan

2024

Inorg. Chem. Front.

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A Novel Double Fluorescence‐Suppressed Probe for the Detection of Hydrazine

et al. 2019

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Hydrazine is an important raw material in medicine and chemical industry. However, N2H4 is very harmful to the environment and human body. Therefore, the detection of hydrazine is particularly important. In this report, a new type of fluorescence probe based on synergistic effect was developed for the detection of N2H4. The fluorescence of the probe was doubly inhibited by the PET (photo‐induced electron transfer) process and the bridled ESIPT (excited‐state intramolecular proton transfer) process. Upon addition of hydrazine, the interrupted PET process and restored ESIPT worked together leading to the fluorescence enhancement. The probe has good specificity for hydrazine. The LOD (limit of detection) was calculated to be 1.45 ppb (0.045 μM) and the linear range was 0.2‐40.0 μM. The contrast experiment showed that the synergistic effect could improve the sensitivity of the probe to hydrazine. In addition, the probe could be used for the quantitative determination of hydrazine in tap water.

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Inhibition of hepatic gluconeogenesis by phenethylhydrazine (phenelzine)

Cited by 13 publications

References 28 publications

Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors

Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors

Configuration-regulated highly luminescent hydrogen–organic frameworks for detection of phenelzine and propofol

A Novel Double Fluorescence‐Suppressed Probe for the Detection of Hydrazine

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