Inhibition of histamine N-methyltransferase (HNMT) in vitro by neuromuscular relaxants

Futó, Judit; Kupferberg, Josh P.; Moss, Jonathan

doi:10.1016/0006-2952(90)90045-m

Cited by 27 publications

(4 citation statements)

References 27 publications

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“…Beaven & Shaff (1979), Mehler et al (1952), Schayer (1952) and Tachibana et al (1986) have observed that histamine N-methyl transferase is quantitatively more important than diamino oxidase in the metabolism of histamine in different animal tissues. Drugs inhibit to different extents the activity of histamine N-methyl transferase in animal tissues (Barth & Lorenz, 1978;Barth et al, 1975;Beaven, 1982;Beaven & Shaff, 1979;Cumming et al, 1990;Duch et al, 1978Duch et al, , 1980Duch et al, , 1984Futo et al, 1990;Harle & Baldo, 1988;Tachibana et al, 1988;Thithapandha & Cohn, 1978) and chloroquine is among the most potent inhibitors (Tachibana et al, 1988). Currently little is known about the inhibition of human histamine Nmethyl transferase by drugs.…”

Section: Introductionmentioning

confidence: 99%

Histamine N‐methyl transferase: inhibition by drugs.

Pacifici

Donatelli

Giuliani

1992

Brit J Clinical Pharma

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1 Histamine N-methyl transferase activity was measured in samples of human liver, brain, kidney, lung and intestinal mucosa. The mean (± s.d.) rate (nmol min-' mg-' protein) of histamine N-methylation was 1.78 ± 0.59 (liver, n = 60), 1.15 0.38 (renal cortex, n = 8), 0.79 ± 0.14 (renal medulla, n = 8), 0.35 0.08 (lung, n = 20), 0.47 ± 0.18 (human intestine, n = 30) and 0.29 ± 0.14 (brain, n = 13).

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Section: Introductionmentioning

confidence: 99%

Histamine N‐methyl transferase: inhibition by drugs.

Pacifici

Donatelli

Giuliani

1992

Brit J Clinical Pharma

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“…Histamine is released into cerebrospinal fluid [43, 44} where it shows an approximately 30-fold higher concentration than in plasma. In addition, it is rapidly metabolized [30], but anaesthesia and especially muscle relaxants may interfere with that [22,34,57]. Histamine as a neurotransmitter has found its role in neuroendocrine reactions (stress reactions) [29,38,39,45] especially in endogenous non-opiate analgesia and is therefore centrally related to pain [38,100], conditions which occur during endoscopy as well as fundamentally in surgery.…”

Section: A Temptative Interpretationmentioning

confidence: 99%

Perioperative nonspecific histamine release : a new classification by aetiological mechanisms and evaluation of their clinical relevance

Duda¹,

Lorenz

Menke

et al. 1993

Annales Françaises d'Anesthésie et de Réanimation

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RI~SUM#: Les auteurs ont r6alis6 quatre 6tudes prospectives dans le but d'6tudier les diff6rents facteurs responsables de la lib6ration d'histamine dans la p6riode p6dop6ratoire. Les r6actions allergiques vraies et les r6actions pseudo-allergiques ne sont pas seules en cause. De nombreux autres m6canismes d'histaminolib6ration sont sugg6r6s : m6canismes neuroendocriniens, lib6ration cons6cutive ,~ des stimuli nociceptifs, facteurs cytotoxiques cons6cutifs au traumatisme tissulaire de l'acte chirurgical et lib6ration induite par les cytokines. Ces mdcanismes ont 6t6 mis en 6vidence darts deux 6tudes prospectives 6tudiant, l'une des patients lors d'une gastroscopie r6alis6e sans pr6m6dication et l'autre, des patients b6n6ficiant d'une chol6cystectomie perccelioscopique. Darts une autre 6tude, une histaminolib6ration par mdcanisme pseudoallergique a 6t6 not6e imm6diatement apr~s l'induction anesth6sique chez un hombre important de patients op6r6s pour divers acres de chirurgie g6n6rale. Dans ces deux cas, I'histaminolib6ration est ind6sirable car elle est ~a l'origine de sympt6mes de gravit6 variable. Les signes cliniques sont surtout cardiovasculaires et respiratoires alors que les signes cutan6s sont souvent absents. Les auteurs consid~-rent que dans la pdriode p6riop6ratoire la lib6ration d'histamine est ind6sirable dans certains cas mais darts d'autres elle n'a pas de cons6quences n6fastes, pouvant m6me 6tre b6n6fique. Une r66valuation des signes cliniques d'histaminolib6ration est n6cessaire puisque les 6tudes ont montr6 que des concentrations plasmatiques de 12 ng. ml -~ d'histamine souvent ne s'accompagnaient d'aucun signe cutan6. Ainsi une histaminolib6ration non sp6cifique n'est, le plus souvent, pas reconnue comme cause d'une hypotension art6rielle p6riop6ratoire en raison du manque de sp6cificit6 de ce sympt6me. Des 6tudes ult6rieures doivent pr6ciser le r61e des m6dicaments antihistaminiques (anti-H1 et anti-H2, doses, choix des patients, moment de Fadministration) darts la pr6vention de l'histaminolib6ration p6riop6ratoire. CLASSIFICATION OF PERIOPERATIVE HISTAMINE RELEASEIn the last conference on prevention of perianaesthetic anaphylactoid reactions, Nancy, 1984 [52], a whole series of mechanisms for nonspecific histamine release was not mentioned at all [62]. Surgical trauma was included, but only one reference could be given at this time [93] and did not challenge the general opinion over 50 years that ,~ histamine does not play an important role in major injury or traumatic shock, [1, 311In this conference [54], however, a considerable increase of knowledge has to b~ reported which creates new hypotheses on functions of histamine in clinical epidemiology ( fig. 1). A new classification has to be found which does not only alter aetiology, but also pathogenesis and disease manifestations, especially in the perioperative and postoperativ e period.

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“…Στον Πίνακα 1.1 συνοψίζονται οι κυριότεροι αναστολείς της HDC και της HNMT (Futo et al 1988, Crooks et al 1990, Cumming et al 1990, Futo et al 1990, Watanabe et al 1990, Jochem et al 2002. (Gurish and Austen 2001).…”

Section: ισταµίνηunclassified

Ανοσοφαρμακολογική Διερεύνηση Της Αλληλεπίδρασης Ισταμίνης Και Κυτοκινών Σε Φυσιολογικές Και Παθολογικές Καταστάσεις

Zampeli¹,

Ζαμπέλη²

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Απόκτηση του τίτλου «Ανανήπτης στη Βασική Υποστήριξη Ζωής και την Αυτόµατη Εξωτερική Απινίδωση» (BLS/AED), αναγνωρισµένο από την Εθνική Επιτροπή Καρδιο-αναπνευστικής Αναζωογόνησης (ΕΕΚΑΑΝ) και το Ευρωπαϊκό Συµβούλιο Ανάνηψης (European Resuscitation Council, ERC) 2007 INTERNATIONAL COURSE ΟN LABORATORY ANIMAL SCIENCE, Ερευνητικό Κέντρο Βιοϊατρικών Επιστηµών «Αλέξανδρος Φλέµιγκ». Απόκτηση τίτλου FELASA "C" Υποτροφίες 2007 Johnson & Johnson (USA) για παρουσίαση της προφορικής ανακοίνωσης Effect of the H 4 R antagonist JNJ7777120 on the histamine content in the rat conjunctiva: a preliminary in vivo study στο 36 ο Annual Meeting of the EHRS, Firenze (Italy) 2008 Roche (Switzerland) για παρουσίαση της προφορικής ανακοίνωσης Systemic challenge with lipopolysaccharide induces histamine levels in the rat conjunctiva and cartilage but not in the hypothalamus στο 37 ο Annual Meeting of the EHRS, Stockholm (Sweden) 2008 British Pharmacological Society, για παρουσίαση της προφορικής ανακοίνωσης Effect of the H 4 R antagonist JNJ7777120 on the cartilage histamine content in rats with adjuvant arthritis στο EPHAR Congress, Manchester (UK) Ξένες Γλώσσες Αγγλικά (άριστα), Γαλλικά (άριστα), Γερµανικά (άριστα), Ουγγρικά (καλώς)

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Inhibition of histamine N-methyltransferase (HNMT) in vitro by neuromuscular relaxants

Cited by 27 publications

References 27 publications

Histamine N‐methyl transferase: inhibition by drugs.

Histamine N‐methyl transferase: inhibition by drugs.

Perioperative nonspecific histamine release : a new classification by aetiological mechanisms and evaluation of their clinical relevance

Ανοσοφαρμακολογική Διερεύνηση Της Αλληλεπίδρασης Ισταμίνης Και Κυτοκινών Σε Φυσιολογικές Και Παθολογικές Καταστάσεις

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