Inhibition of histone methyltransferase SETD8 represses DNA virus replication

Chen, Lin; Yang, Chen; Tang, Shan-Bo; Long, Qiaoyun; Chen, Jidong; Wu, Min; Li, Lianyun

doi:10.1016/j.cellin.2022.100033

Cited by 1 publication

(1 citation statement)

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“…Inhibition of LSD1 results in heterochromatic suppression of the HSV-1 genome and subsequently affects viral infection [ 18 , 19 ]. SETD8, one enzyme for histone H4K20me, has been shown to methylate PCNA and regulate DNA virus replication [ 20 ]. Inhibition of H3K27me3 demethylase JMJD3 and UTX by a small molecule, GSK-J4, inhibits HSV-1 reactivation from sensory neurons [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity

Yang,

Wang,

Long

et al. 2024

PLoS Pathog

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Proper transcription regulation by key transcription factors, such as IRF3, is critical for anti-viral defense. Dynamics of enhancer activity play important roles in many biological processes, and epigenomic analysis is used to determine the involved enhancers and transcription factors. To determine new transcription factors in anti-DNA-virus response, we have performed H3K27ac ChIP-Seq and identified three transcription factors, NR2F6, MEF2D and MAFF, in promoting HSV-1 replication. NR2F6 promotes HSV-1 replication and gene expression in vitro and in vivo, but not dependent on cGAS/STING pathway. NR2F6 binds to the promoter of MAP3K5 and activates AP-1/c-Jun pathway, which is critical for DNA virus replication. On the other hand, NR2F6 is transcriptionally repressed by c-Jun and forms a negative feedback loop. Meanwhile, cGAS/STING innate immunity signaling represses NR2F6 through STAT3. Taken together, we have identified new transcription factors and revealed the underlying mechanisms involved in the network between DNA viruses and host cells.

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