Inhibition of HIV-1 infection by human pegivirus type 1-derived peptides is affected by human pegivirus type 1 genotype and HIV-1 coreceptor tropism

Ruegamer, Tamara; Hoffmann, Rebecca; Rohrhofer, Anette; Audebert, Franz; Salzberger, Bernd; Korn, Klaus; Schuster, Philipp; Eichler, Jutta; Schmidt, Bárbara

doi:10.1097/qad.0000000000001926

Cited by 5 publications

(4 citation statements)

References 63 publications

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“…Subtype 2b and genotype 5 were already related to higher rates of CD4+ T-cells compared to subtype 2a and genotype 1 [19, 33], and genotype 7 has already been associated with slower progression to AIDS [34]. It is thought that the different HPgV-1 genotypes have different tropisms to the CXCR4 and CCR5 coreceptors used by HIV-1 for entry into host cells, which would be determinant in the evolution of HIV-1 infection [35]. The competition for these coreceptors has also been suggested [36], since both viruses present cell tropism to CD4+ T-cells [37].…”

Section: Discussionmentioning

confidence: 99%

Molecular and Clinical Profiles of Human Pegivirus Type 1 Infection in Individuals Living with HIV-1 in the Extreme South of Brazil

Mota

Finger‐Jardim

Silva

et al. 2019

BioMed Research International

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Human pegivirus type 1 (HPgV-1) infection has been associated with a beneficial effect on the prognosis of human immunodeficiency virus type 1 (HIV-1)-coinfected individuals. However, the mechanisms involved in this protection are not yet fully elucidated. To date, circulating HPgV-1 genotypes in HIV-1-infected individuals have not yet been identified in the extreme south of Brazil. The present study aimed to determine the genotypic circulation of HPgV-1 and the influence of HPgV-1 status and persistence time on the evolution of HIV-1 infection. A retrospective cohort of 110 coinfected individuals was analyzed. Samples were subjected to viral RNA extraction, cDNA synthesis, nested PCR, and genotyping. Genotypes 1 (2.8%), 2 (47.9% of subtype 2a and 42.3% of subtype 2b), and 3 (7%) were identified. In antiretroviral treatment-naïve subjects HPgV-1 subtype 2b was associated with lower HIV-1 viral load (VL) rates (p = 0.04) and higher CD4+ T-cell counts (p = 0.03) than was subtype 2a, and the positivity for HPgV-1 was associated with higher CD4+ T-cell counts (p = 0.02). However, there was no significant difference in HIV-1 VL between HPgV-1-positive and HPgV-1-negative subjects (p = 0.08). There was no significant association between the different groups in HPgV-1 persistence and median HIV-1 VL (p = 0.66) or CD4+ T-cell counts (p = 0.15). HPgV-1 subtype 2b is associated with better prognosis of HIV-1 infection. Although HPgV-1 infection is persistent, our data suggest that the time of infection does not influence HIV-1 VL or CD4+ T-cell counts in coinfected subjects.

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Section: Discussionmentioning

confidence: 99%

Molecular and Clinical Profiles of Human Pegivirus Type 1 Infection in Individuals Living with HIV-1 in the Extreme South of Brazil

Mota

Finger‐Jardim

Silva

et al. 2019

BioMed Research International

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“…Antibodies directed toward the envelope HPgV glycoprotein E2, which is thought to be the immunodominant antigenic site, are detected as viremia is cleared [ 18 ]. While the pathogenicity of this virus remains unclear, HPgV-1 has a propensity to co-infect individuals with other viral infections, particularly human immunodeficiency virus (HIV) [ 19 , 20 ] and HCV [ 6 , 21 ]. HPgV interferes with the pathogenicity of HIV [ 22 ] and slows disease progression [ 7 , 9 , 19 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…While the pathogenicity of this virus remains unclear, HPgV-1 has a propensity to co-infect individuals with other viral infections, particularly human immunodeficiency virus (HIV) [ 19 , 20 ] and HCV [ 6 , 21 ]. HPgV interferes with the pathogenicity of HIV [ 22 ] and slows disease progression [ 7 , 9 , 19 , 23 , 24 ]. Indeed, epidemiological evidence showed that longer period of HPgV viremia is associated with greater survival among HIV-positive individuals [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

A Case of Persistent Human Pegivirus Infection in Two Separate Pregnancies of a Woman

et al. 2022

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Human pegivirus (HPgV) is best known for persistent, presumably non-pathogenic, infection and a propensity to co-infect with human immunodeficiency virus or hepatitis C virus. However, unique attributes, such as the increased risk of malignancy or immune modulation, have been recently recognized for HPgV. We have identified a unique case of a woman with high levels HPgV infection in two pregnancies, which occurred 4 years apart and without evidence of human immunodeficiency virus or hepatitis C virus infection. The second pregnancy was complicated by congenital heart disease. A high level of HPgV infection was detected in the maternal blood from different trimesters by RT-PCR and identified as HPgV type 1 genotype 2 in both pregnancies. In the second pregnancy, the decidua and intervillous tissue of the placenta were positive for HPgV by PCR but not the chorion or cord blood (from both pregnancies), suggesting no vertical transmission despite high levels of viremia. The HPgV genome sequence was remarkably conserved over the 4 years. Using VirScan, sera antibodies for HPgV were detected in the first trimester of both pregnancies. We observed the same anti-HPgV antibodies against the non-structural NS5 protein in both pregnancies, suggesting a similar non-E2 protein humoral immune response over time. To the best of our knowledge, this is the first report of persistent HPgV infection involving placental tissues with no clear indication of vertical transmission. Our results reveal a more elaborate viral-host interaction than previously reported, expand our knowledge about tropism, and opens avenues for exploring the replication sites of this virus.

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Section: Introductionmentioning

confidence: 99%

Persistent Human Pegivirus Infection across Two Pregnancies without Evidence of Vertical Transmission

Garand¹,

Huang²,

Goessling³

et al. 2022

Preprint

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Human pegivirus (HPgV) is best known for persistent, presumably non-pathogenic, infection and a propensity to co-infect with human immunodeficiency virus or hepatitis C virus. However, unique at-tributes, such as the increased risk of malignancy or immune modulation, have been recently recognized for HPgV. We have identified a unique case of a woman with high levels HPgV infection in two preg-nancies, which occurred 4 years apart, without evidence of human immunodeficiency virus or hepatitis C virus infection. The second pregnancy was complicated by congenital heart disease. A high level of HPgV infection was detected in maternal blood from different trimesters by RT-PCR and identified as HPgV type 1 genotype 2 in both pregnancies. In the second pregnancy, the decidua and intervillous tissue of the placenta were positive for HPgV by PCR but not the chorion or cord blood (from both pregnancies), suggesting no vertical transmission despite high levels of viremia. The HPgV genome sequence was remarkably conserved over the 4 years. Using VirScan, sera antibodies for HPgV were detected in the first trimester of both pregnancies. We observed the same anti-HPgV antibodies against the non-structural NS5 protein in both pregnancies, suggesting a similar non-E2 protein humoral immune response over time. To the best of our knowledge, this is the first report of persistent HPgV infection involving placental tissues with no evidence of vertical transmission. Our results reveal a more elaborate viral-host interaction than previously reported, expand our knowledge about tropism, and opens avenues for exploring the replication sites of this virus.

show abstract

Inhibition of HIV-1 infection by human pegivirus type 1-derived peptides is affected by human pegivirus type 1 genotype and HIV-1 coreceptor tropism

Cited by 5 publications

References 63 publications

Molecular and Clinical Profiles of Human Pegivirus Type 1 Infection in Individuals Living with HIV-1 in the Extreme South of Brazil

Molecular and Clinical Profiles of Human Pegivirus Type 1 Infection in Individuals Living with HIV-1 in the Extreme South of Brazil

A Case of Persistent Human Pegivirus Infection in Two Separate Pregnancies of a Woman

Persistent Human Pegivirus Infection across Two Pregnancies without Evidence of Vertical Transmission

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