2004
DOI: 10.1016/s0140-6736(04)16453-2
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Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MlP-lα, MIP-1β, and SDF-1

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Cited by 173 publications
(188 citation statements)
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“…These include HLA-type (1)(2)(3)(4), HIV co-receptor expression (5), the cytidine deaminase APOBEC3G (6,7), tetherin (BST-2) (8), SAMHD1 (9,10), and an array of cytokines. Some cytokines such as type 1 and type 3 interferons, chemokines (e.g., stromal cell-derived factor 1, macrophage inflammatory factor 1a, RANTES (regulated on activation normal T cell expressed and secreted), and IL-27) inhibit HIV replication (11)(12)(13), whereas some enhance replication (IL-6 (14), tumor necrosis factor-␣ (15), IL-12 (16), and colony-stimulating factors (17,18)), and some are capable of either inhibiting or enhancing replication depending upon the culture system and conditions. In this regard, IL-2 has been shown to be capable of suppressing HIV-1 replication through the enhancement of CD8ϩ T cell function and enhancing HIV-1 replication in primary cultures of CD4ϩ T cells (19 -21).…”
Section: Il-2 Has Been Used In Culture Of Primary T Cells To Maintainmentioning
confidence: 99%
“…These include HLA-type (1)(2)(3)(4), HIV co-receptor expression (5), the cytidine deaminase APOBEC3G (6,7), tetherin (BST-2) (8), SAMHD1 (9,10), and an array of cytokines. Some cytokines such as type 1 and type 3 interferons, chemokines (e.g., stromal cell-derived factor 1, macrophage inflammatory factor 1a, RANTES (regulated on activation normal T cell expressed and secreted), and IL-27) inhibit HIV replication (11)(12)(13), whereas some enhance replication (IL-6 (14), tumor necrosis factor-␣ (15), IL-12 (16), and colony-stimulating factors (17,18)), and some are capable of either inhibiting or enhancing replication depending upon the culture system and conditions. In this regard, IL-2 has been shown to be capable of suppressing HIV-1 replication through the enhancement of CD8ϩ T cell function and enhancing HIV-1 replication in primary cultures of CD4ϩ T cells (19 -21).…”
Section: Il-2 Has Been Used In Culture Of Primary T Cells To Maintainmentioning
confidence: 99%
“…As Xiang et al reported that the co-infection of GBV-C suppressed the HIV-1 replication through upregulation of RANTES, a natural CCR5 ligand, and also known as CCL5, in an in vitro study (25), we assessed the scenario by measuring the RANTES concentration in patients' plasma. In contrast to the in vitro study, however, much higher RANTES concentrations were observed in GBV-C-uninfected individuals.…”
Section: (A) (B)mentioning
confidence: 99%
“…In experimental studies, GBV-C infection of peripheral-blood mononuclear cells resulted in decreased replication of both clinical and laboratory HIV strains that use either CCR5 or CXCR4 as their co-receptor. GBV-C induces HIV inhibitory chemokines and reduces the expression of HIV co-receptor CCR5 in vitro, that could block or reduce the decline of CD4 counts, hence justifying the better prognosis 24,25 .…”
Section: Introductionmentioning
confidence: 99%