Inhibition of human neutrophil elastase by ergosterol derivatives from the mycelium of Phellinus linteus

Lee, Ik‐Soo; Bae, KiHwan; Yoo, Jae Won; Ryoo, In‐Ja; Kim, Bo Yeon; Ahn, Jong Seog; Yoo, Ick Dong

doi:10.1038/ja.2012.42

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…(22 E ,24 R )-3β-hydroxyergosta-7,22-diene-6-one, 3β-OH epimer of 1 was reported to inhibit antigen-induced degradation of RBL-2H3 cells 31 and human neutrophil elastase. 32 The hydroxy group at C-3 of ergosterol is reported not to affect the bioactivity such as anticancer activity and is used as a linkage position for preparing molecular proves. 33,34 Considering these reports, 1 may show similar activity to its epimer.…”

Section: Resultsmentioning

confidence: 99%

Ergostane-Type Sterols From Several Cordyceps Strains

Yoneyama

Takahashi

Grudniewska

et al. 2022

Natural Product Communications

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Ergosterol is an essential component for fungi, including entomopathogenic fungi like Cordyceps. Cordyceps has been used as a traditional medicine in Japan and China and possesses various unique ergostane-type sterols, those exhibit bioactivities. In this manuscript, we reported the isolation of 2 new ergostane-type sterols, 1 and 2 along with ten sterols (3-12) from 7 strains of Cordyceps related fungal strains, Cordyceps takaomontana NBRC 101754, Metarhizium owariense NBRC 33258, Polycephalomyces formosus NBRC 109994, Cordyceps tuberculata NBRC 106948, Cordyceps tenuipes NBRC 108997, Cordyceps sp. NBRC 106954, and Tolypocladium paradoxum NBRC 106958 collected fruiting bodies of Ophiocordyceps heteropoda. In addition, the antitrypanosomal activity and antimicrobial activity of isolates were tested to find 6 showed the antitrypanosomal activity, and the minimum inhibitory concentration (MIC) value was confirmed as 1.41 µg/mL. In the antimicrobial assay, the MIC value of 8 against methicillin-resistant Staphylococcus aureus was determined to be 3.1 µg/mL.

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Section: Resultsmentioning

confidence: 99%

Ergostane-Type Sterols From Several Cordyceps Strains

Yoneyama

Takahashi

Grudniewska

et al. 2022

Natural Product Communications

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“…Inhibition of this enzyme can prevent the loss of skin elasticity, thereby preventing skin aging. Yoo et al reported the HNE-inhibitory properties of Phellinus linteus mycelium components [ 198 ]. All three tested epoxides 31a , 34, and 50 showed significant activity with ID 50 ranging from 28.2 to 75.1 μM.…”

Section: Epoxidesmentioning

confidence: 99%

“…Yoo et al studied the HNE-inhibitory potency of ergostanes isolated from the mycelium of Phellinus linteus [ 198 ]. Methyl ether 61a revealed the highest activity among all tested compounds with an IC 50 14.6 μM, which was comparable with the positive control (epigallocatechin gallate, IC 50 12.5 μM).…”

Section: Polyolsmentioning

confidence: 99%

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

2022

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Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.

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Hispidin derived from Phellinus linteus affords protection against acrylamide-induced oxidative stress in Caco-2 cells

Chen

Shen

et al. 2014

Chemico-Biological Interactions

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Inhibition of human neutrophil elastase by ergosterol derivatives from the mycelium of Phellinus linteus

Cited by 8 publications

References 30 publications

Ergostane-Type Sterols From Several Cordyceps Strains

Ergostane-Type Sterols From Several Cordyceps Strains

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

Hispidin derived from Phellinus linteus affords protection against acrylamide-induced oxidative stress in Caco-2 cells

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