2015
DOI: 10.1016/j.jff.2015.10.003
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Inhibition of human α-amylase by dietary polyphenols

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Cited by 137 publications
(109 citation statements)
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References 36 publications
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“…Conversely, Nyambe‐Silavwe et al. () used a concentration interval closer to that of the present study (5 to 70 μM compared with 1 to 7.5 μM). It seems therefore that the inhibition profile of these alpha‐amylases by flavanols rather depends on the experimental conditions, especially the concentration of the inhibitor and the degree of purity of the enzyme.…”
Section: Resultsmentioning
confidence: 62%
See 1 more Smart Citation
“…Conversely, Nyambe‐Silavwe et al. () used a concentration interval closer to that of the present study (5 to 70 μM compared with 1 to 7.5 μM). It seems therefore that the inhibition profile of these alpha‐amylases by flavanols rather depends on the experimental conditions, especially the concentration of the inhibitor and the degree of purity of the enzyme.…”
Section: Resultsmentioning
confidence: 62%
“…Lastly, it is worth mentioning that the HSA catalyzed hydrolysis of amylopectin—the main constituent of most starches—is inhibited by EGCG, acarbose, quercetin, luteolin, and green tea with a IC 50 comprised between 10 μM (acarbose) and 83 μM (quercetin). Similarly, with the HSA/amylose couple, IC 50 is comprised between 3.5 μM (acarbose) and 26.3 μM (luteolin) (Nyambe‐Silavwe et al., ). Thus, overall, these five HSA inhibitors are 3‐ to 10‐fold more effective on the amylose hydrolysis than on the amylopectin hydrolysis.…”
Section: Resultsmentioning
confidence: 99%
“…The maximum DMSO concentration (5%) in the assay did not affect the enzyme activity as assessed in control incubations. Inhibition of human salivary α‐amylase was tested as previously described . Maltase, sucrase and isomaltase assays were conducted as before with some modifications.…”
Section: Methodsmentioning
confidence: 99%
“…The effect of on α-amylase (EC 3.2.1.1) activity was determined according to the method described in protocol 16,17 with some modification. Preliminary experiments were conducted to establish optimal assay conditions such as temperature, substrate enzyme and inhibitor concentration.…”
Section: Anti-diabetic Activitymentioning
confidence: 99%