Inhibition of inducible tumor necrosis factor-α expression by the fungal epipolythiodiketopiperazine gliovirin

Rether, Jan; Serwe, Annegret; Anke, Timm; Erkel, Gerhard

doi:10.1515/bc.2007.066

Cited by 22 publications

(28 citation statements)

References 54 publications

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“…are economically useful biofungicides, plant growth promoters, sources of secondary metabolites for agricultural and pharmaceutical applications, and sources of industrial enzymes (11,21). T. virens is a commercial biofungicide and also produces important secondary metabolites, such as gliotoxin, gliovirin, viridin, and viridiol, which are antimicrobial (gliotoxin, gliovirin), have herbicidal properties (viridiol), and have pharmaceutical or clinical significance (gliotoxin, gliovirin, viridin) (13,14,23,26,30,38). Gliotoxin, the most abundant secondary metabolite synthesized by T. virens, is also a pathogenicity determinant in the human opportunistic pathogen A. fumigatus (34).…”

Section: Discussionmentioning

confidence: 99%

Regulation of Morphogenesis and Biocontrol Properties inTrichoderma virensby a VELVET Protein, Vel1

Mukherjee

Kenerley

2010

Appl Environ Microbiol

127

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Mycoparasitic strains of Trichoderma are applied as commercial biofungicides for control of soilborne plant pathogens. Although the majority of commercial biofungicides are Trichoderma based, chemical pesticides, which are ecological and environmental hazards, still dominate the market. This is because biofungicides are not as effective or consistent as chemical fungicides. Efforts to improve these products have been limited by a lack of understanding of the genetic regulation of biocontrol activities. In this study, using gene knockout and complementation, we identified the VELVET protein Vel1 as a key regulator of biocontrol, as well as morphogenetic traits, in Trichoderma virens, a commercial biocontrol agent. Mutants with mutations in vel1 were defective in secondary metabolism (antibiosis), mycoparasitism, and biocontrol efficacy. In nutrient-rich media they also lacked two types of spores important for survival and development of formulation products: conidia (on agar) and chlamydospores (in liquid shake cultures). These findings provide an opportunity for genetic enhancement of biocontrol and industrial strains of Trichoderma, since Vel1 is very highly conserved across three Trichoderma species.Trichoderma-based formulation products account for about 60% of the biofungicide market (35). Despite the use of Trichoderma-based biofungicides as an alternative and additive to chemical fungicides, the applications of these preparations are limited because their efficacy is lower than that of fungicides.

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Section: Discussionmentioning

confidence: 99%

Regulation of Morphogenesis and Biocontrol Properties inTrichoderma virensby a VELVET Protein, Vel1

Mukherjee

Kenerley

2010

Appl Environ Microbiol

127

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“…Four-(Hex-1-Yen-3-ene),4(Pent-1,3-diene) amine, reported in this study, together with 9-epi-viridiol [89] and trichoderide A [90] all have anticancer properties. In contrast, gliovirin, a previously isolated epipolythiodiketopiperazine from Trichoderma harzianum strongly inhibited the production of Tumor Necrosis Factor-(TNF-) [93] which is known for its antineoplastic activity. Counteracting activities of different metabolites from the same species has to be considered in purification and testing of new anticancer agents.…”

Section: [88]mentioning

confidence: 97%

Fungal Secondary Metabolites: A Promising Source of Antineoplastic Drugs

Ahmed¹,

Shikh²,

Ghoneimy³

et al. 2010

CCTR

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The rapid progress in understanding the molecular biology of cancer has made a large impact on the design and development of novel therapeutic strategies prompted by the multi-factorial limitations of the current chemotherapeutic modalities. Given that the development of newer antineoplastic drugs continues to rely heavily on isolation from natural sources rather than applications based on rational drug design and combinatorial chemistry, fungal secondary metabolites rank high on the list of potential targets for the discovery of novel chemotherapeutic agents. They represent a diverse group of bioactive compounds characterized by their origin and biosynthetic pathways. Also, they serve as regulators, chemical messengers in developmental processes, or as antibiotics. A broad variety of fungal secondary metabolites possess potent antitumor activity. Alpha sarcin, gliotoxins, trichodimerol, L-lysine alpha-oxidase, fumagillin, declauxin, chrysanthones, fungal-derived low molecular weight inhibitors of angiogenesis e.g. TNP-470, retamycin, daunorubicin, and doxorubicin all have been shown to exert potent antitumor activity. Inhibition of protein synthesis, induction of DNA breakage and apoptosis, as well as blockade of angiogenesis are examples of the multiple antitumor mechanisms of fungal secondary metabolites. The current review explores the potential use of fungal secondary metabolites as antineoplastic drugs with special reference to the novel hepatoma growth-inhibition factor that we recently characterized from Trichoderma viride.

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“…1-phenyl-3-methylpyrazolones oxidoreductase mediators [297] aryl tetral226in lignans bioactive compounds [298] podophyllotoxin bioactive compounds [298] Trametes versicolor funatrol D bioactive compound [299] isodrimenediol sesquiterpenes (anticancer) [299] tramspiroins sesquiterpenes (anticancer) [299] triterpenes bioactive compounds [300] Database on potential toxigenic capacities of microorganisms used for industrial production 2,4-di-tert-butylphenol bioactive compound [310] 2,6,10-trimethylundeca-5,9-dienal bioactive compound [310] 2-phenylethanol bioactive compound [311] 6-pentyl-alpha-pyrone bioactive compound [312,313] 6-methyl-1,3,8-trihydroxyanthraquinone antifungal [308] 6-n-pentyl-a-pyrone bioactive compound [311] 6-pentyl-2H-pyran-2-one antifungal [308] alpha-cubebene bioactive compound [310] alpha-curcumene bioactive compound [310] anthraquinones antifungal [314] azaphilone antifungal [307,309] b-bisabolene bioactive compound [310] biformen (6CI) bioactive compound [310] butenolide antifungal [307,309] [318] gliotoxin bioactive compound [319] gliovirin bioactive compound [319,320] harzianic acid siderophore [321] harzianolide anti-phytopathogen [307,309,322] harzianopyridone anti-phytopathogen [307][308][309] harziphilone bioactive compound [318] hexahydrofarnesol bioactive compound …”

Section: Trametes Hirsutamentioning

confidence: 99%

Database on the taxonomical characterisation and potential toxigenic capacities of microorganisms used for the industrial production of food enzymes and feed additives, which do not have a recommendation for Qualified Presumption of Safety

Benito

Ibáñez

Moncho

et al. 2017

EFSA Supporting Publications

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The present work constitutes the external scientific report of the EFSA open call OC/EFSA/FEED/2015/01. The aim of the call was to provide EFSA with a database from a review on the taxonomical description and potential toxigenic capacities of microorganisms used for the industrial production of feed additives and food enzymes. The review includes microorganisms used as source of feed additives and food enzymes for which EFSA has received or can potentially receive applications for safety assessment, and which have not been recommended for Qualified Presumption of Safety status. The database also comprises the molecular taxonomical identifiers and biosynthetic pathways involved in the production of toxic compounds and the responsible genes. The main result of the project is shown as a database developed according to the EFSA data structure. The methodological aspects and the queries used in the systematic search, as well as the procedure applied for the screening of scientific documents retrieved are described in this report. Details are available in supplementary appendices.In total, 22970 scientific documents were screened in the literature search, from which 411 were initially selected for providing pertinent data for the scope of the project. From the review of the selected articles, 474 bioactive secondary metabolites were recorded and 59 compounds were further studied in order to obtain data on their toxicology and the conditions in which they are produced by the microorganisms used in industrial fermentations. The database generated in this project comprises details that characterise, when available, the production conditions, genes involved and toxicity of these 59 compounds. This provides information that can be used to establish safety measures when using potentially toxigenic microorganisms in industrial fermentations Disclaimer: The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. Acknowledgements:We thank the following EFSA satff: Jaime Aguilera, Margarita Aguilera-Gómez, Jane Richardson, Mario Monguidi and Davide Gibin for their valuable help and collaboration throughout the project. We also would like to thank the members of AINIA: Sonia Porta, Lidia Tomás, Joaquin Espí and Juan Antonio Nieto for providing expertise in biotechnology and molecular biology and contributing with their efforts to achieve the goals of this project, and Violeta Gómez from the University of Navarra for her colla...

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Inhibition of inducible tumor necrosis factor-α expression by the fungal epipolythiodiketopiperazine gliovirin

Cited by 22 publications

References 54 publications

Regulation of Morphogenesis and Biocontrol Properties inTrichoderma virensby a VELVET Protein, Vel1

Regulation of Morphogenesis and Biocontrol Properties inTrichoderma virensby a VELVET Protein, Vel1

Fungal Secondary Metabolites: A Promising Source of Antineoplastic Drugs

Database on the taxonomical characterisation and potential toxigenic capacities of microorganisms used for the industrial production of food enzymes and feed additives, which do not have a recommendation for Qualified Presumption of Safety

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