Inhibition of Inflammation by Popillia flavosellata Ethanol Extract in LPSinduced RAW264.7 Macrophages

윤영일,; 황재삼,; 김미애,; 안미영,; 이영보,; 한명세,; 구태원,; 윤은영,

doi:10.5352/jls.2015.25.9.993

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…NF-κB comprises P50 and P65 (RelA) and is normally inactivated by binding with Inhibitors of κBα (IκBα) [7]. In LPS-treated RAW 264.7 macrophages, the NF-κB signaling pathway is activated by TLR-4 to phosphorylate IκBα by activating IκBα kinase (IKK), which phosphorylates IκBα [8,9]. When phosphorylated IκBα is isolated from NF-κB, NF-κB functions as a transcription factor.…”

Section: Introductionmentioning

confidence: 99%

Effect of sandalwood oil on inhibition of reactive oxygen species generation and lipopolysaccharideinduced inflammation through down-regulation of the nuclear factor-κB signaling pathways

Lee¹,

Kim²,

Lim³

2021

ScienceAsia

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We investigated the antioxidative and anti-inflammatory effects of sandalwood oil and attempted to elucidate its underlying mechanism of action. The antioxidant activities of sandalwood oil were assessed using various methods: 1.1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS + ) radical scavenging assays, as well as DNA protection ability and reactive oxygen species (ROS) generation. The cell viability of sandalwood oil in RAW 264.7 cells (murine macrophage) was investigated by tetrazolium salt (MTT) assay. The nuclear factor kappa B (NF-κB) activation was analyzed by western blot analysis in LPS-induced RAW 264.7 cells. NF-κB nuclear translocation was evaluated by immunofluorescence staining. Furthermore, we examined ROS generation using DCF-DA in H 2 O 2 -stimulated RAW 264.7 cells. Sandalwood oil inhibited IκBα phosphorylation and NF-κB activation and its translocation into the nucleus. Sandalwood oil shows antioxidant activity in vitro, suggesting that it may inhibit the promotion of the NF-κB-mediated inflammatory signaling pathway induced by ROS.

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Section: Introductionmentioning

confidence: 99%

Effect of sandalwood oil on inhibition of reactive oxygen species generation and lipopolysaccharideinduced inflammation through down-regulation of the nuclear factor-κB signaling pathways

Lee¹,

Kim²,

Lim³

2021

ScienceAsia

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The Functional Effects on Anti-oxidant and Anti-inflammation of <i>Veronica persica</i> Poir. Extracts

Park¹,

Nam²,

Li³

et al. 2018

Korean J. org. Agric.

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Modulation Effects on Acute Orofacial Inflammatory Pain in Rats by Curcuma longa L., Curcuma aromatica Salisb., Zingiber officinale Rosc. Extracts

Kim

Choi

Kim

et al. 2019

BSL

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Curcuma longa L. (C.L), Curcuma aromatica Salisb. (C.A) and Zingiber officinale Rosc. (Z.O) of Zingiberaceae plants which are well known as effects of natural anti-oxidant, anti-cancer and anti-inflammatory. We examined that the Zingiberaceae plants are involved in development and modulation of orofacial pain in rats. Male, 7-to 8-week-old, Sprague-Dawley rats weighing 240~280 g were used in this study. Experiments were performed using acute pain model that was caused by the injection of 5% formalin into the right vibrissa pad. The number of scratching or rubbing to the injection site was recorded for 9 consecutive 5-minute intervals following injection of formalin. The experimental groups were acute orofacial inflammatory pain; control group (formalin, 5%), vehicle group (5% formalin after sodium carboxymethyl cellulose), single administration group, single mixed administration group, repeated administration group. The experiments were performed various concentrations of Zingiberaceae plants extract. Therefore, oral administration of C.L, C.A, and Z.O (p.o., concentrations of 12.5, 25 mg/mL) in orofacial inflammatory pain model substantially decrease the nociceptive behavior in a concentration dependent manner. And it tended to decrease at low concentration (12.5 mg/ mL) of single mixed and repeated administration more than single administration. This result means that Zingiberaceae plants extract affects the modulation of acute orofacial inflammatory pain. Thus, Zingiberaceae plants extract may be a potential therapeutic treatment for orofacial inflammatory pain.

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Inhibition of Inflammation by Popillia flavosellata Ethanol Extract in LPSinduced RAW264.7 Macrophages

Cited by 4 publications

References 25 publications

Effect of sandalwood oil on inhibition of reactive oxygen species generation and lipopolysaccharideinduced inflammation through down-regulation of the nuclear factor-κB signaling pathways

Effect of sandalwood oil on inhibition of reactive oxygen species generation and lipopolysaccharideinduced inflammation through down-regulation of the nuclear factor-κB signaling pathways

The Functional Effects on Anti-oxidant and Anti-inflammation of <i>Veronica persica</i> Poir. Extracts

Modulation Effects on Acute Orofacial Inflammatory Pain in Rats by Curcuma longa L., Curcuma aromatica Salisb., Zingiber officinale Rosc. Extracts

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