Inhibition of Inflammatory Pain by Activating B-Type Natriuretic Peptide Signal Pathway in Nociceptive Sensory Neurons

Zhang, Fang-Xiong; Liu, Xingjun; Gong, Li-qin; Yao, Jun-Ru; Li, Kaicheng; Li, Ziyan; Lin, Li-Bo; Lu, Yao; Xiao, Huasheng; Liu, Bao; Zhang, Xiao-Hui; Zhang, Xu

doi:10.1523/jneurosci.0657-10.2010

Cited by 72 publications

(105 citation statements)

References 58 publications

(81 reference statements)

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“…The thermal sensitivity of C2 correlates with the presence of Trpv1 and Trpv2 in the Nppb gene network and the role of NBP in thermal hyperalgesia [19,45]. Both C4 and C5 are MHNs (IS).…”

Section: Functional Annotations Of Neuron Types and Related Gene-netwmentioning

confidence: 99%

“…Gene expression profiles of DRG tissue have been also analyzed by microarray and RNA-sequencing (RNA-seq) techniques [17,18]. Although these methods have helped to identify the expression of neuromodulators such as natriuretic peptide B (NPB) [19] and regulators of Na + , K + -ATPase (NKA), including the γ-subunit of NKA (FXYD domain-containing ion transport regulator 2, Fxyd2) [20][21][22], they cannot provide a global view of the transcriptional profiles of individual neurons.…”

Section: Introductionmentioning

confidence: 99%

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Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

et al. 2015

Cell Res

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“…The thermal sensitivity of C2 correlates with the presence of Trpv1 and Trpv2 in the Nppb gene network and the role of NBP in thermal hyperalgesia [19,45]. Both C4 and C5 are MHNs (IS).…”

Section: Functional Annotations Of Neuron Types and Related Gene-netwmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

et al. 2015

Cell Res

404

432

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“…Zhang et al (2010) have shown that 90% of the small IB4-positive DRG neurons from the skin have K Ca currents and RT-PCR of mRNA from these neurons shows the expression of multiple splice variants. Yu et al (2015) have shown that CaMKII blockage increases sensory sensitivity and DRG neurons firing rate.…”

Section: Membrane Properties Associated With Tonic and Phasic Firing mentioning

confidence: 99%

Morphological and functional diversity of first-order somatosensory neurons

2017

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First-order somatosensory neurons transduce and convey information about the external or internal environment of the body to the central nervous system. They are pseudo unipolar neurons with cell bodies residing in one of several ganglia located near the central nervous system, with the short branch of the axon connecting to the spinal cord or the brain stem and the long branch extending towards the peripheral organ they innervate. Besides their sensory transducer and conductive role, somatosensory neurons also have trophic functions in the tissue they innervate and participate in local reflexes in the periphery. The cell bodies of these neurons are remarkably diverse in terms of size, molecular constitution, and electrophysiological properties. These parameters have provided criteria for classification that have proved useful to establish and study their functions. In this review, we discuss ways to measure and classify populations of neurons based on their size and action potential firing pattern. We also discuss attempts to relate the different populations to specific sensory modalities.

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“…Building upon a series of important results on pain inhibition, Zhang and colleagues identified B-type natriuretic peptide (BNP) and its receptor involved in pain modulation. They demonstrated that activate BNP in nociceptive neurons could inhibit the inflammatory pain [22]. Later they revealed another protein, Activin C, is also required for inflammatory pain suppression.…”

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confidence: 99%

Recent progress of sensory system research in China

Wang

Liu

2012

Sci. China Life Sci.

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From human to insects, the sensory system is the part of the nervous system responsible for processing sensory information. Commonly recognized sensory systems include vision, hearing/auditory, smell/olfactory, taste/gustatory and somatic sensation. The research on sensory system investigates peripheral sensory neurons, neural pathways, and the more central brain involved in sensory perception. Chinese neuroscientists have been working to decode the sensory system for years. With improved fundings and research environment in recent years, significant progress has been made in neuroscience [1,2]. Here we review some recent advances in the basic research on sensory system in China.A critical step to understand vision is to know how and where the visual perception is processed. Various Chinese research institutions and universities have made progress in vision research [3]. With fMRI and computational approaches, Fang and colleagues in Peking University have made a series of important findings on the neural mechanisms of human visual processes. Their findings suggested, for the first time, that the bottom-up saliency map is created in the V1 area, challenging the dominant view that the saliency map is generated in the parietal cortex [4]. They further found the effect of visual perceptual grouping --enhancing the high-level shape representation and attenuating the low-level feature representation [5].Research on visual processing in the cortex by Li's group (Institute of Biophysics, Chinese Academy of Sciences) showed that the feedback projection from area posteromedial lateral suprasylvian (PMLS) can enhance the direction selectivity of striate neurons but exert little effect on the orientation tuning in cats, indicating an important role of PMLS in visual motion processing in the cerebral cortex [6]. Investigation on visual perception in mice by Zhu and coworkers (Southwest Forestry University, Kunming Institute of Zoology, Chinese Academy of Sciences) focused on the effects of different object properties. They took an interesting approach to use a behavioral paradigm to study the effect of different visual cues in visual perception [7], and found that mice could distinguish and extract topological properties of the objects [8].The auditory system takes part in sound signal recognition and signal processing with central auditory neurons [9]. While previous studies of human sound level discrimination were always performed in monaural conditions, Zhang's group (East China Normal University) focused on preceding sound level discrimination in binaural conditions. Their results showed that the just noticeable difference (JND) of the low level preceding sound could not show significant effects compared with no sound (quiet), while moderate to high levels of preceding sound significantly increased the JND of the level of the successive sound [10]. Taking advantages of the hypertrophied auditory systems in bats, which are relatively easy to study, Chen and colleagues (Central China Normal University) investigated the inf...

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Inhibition of Inflammatory Pain by Activating B-Type Natriuretic Peptide Signal Pathway in Nociceptive Sensory Neurons

Cited by 72 publications

References 58 publications

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

Morphological and functional diversity of first-order somatosensory neurons

Recent progress of sensory system research in China

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