Inhibition of Intercellular Adhesion in Herpex Simplex Virus Infection by Glycyrrhizin

Huang, Wen; Chen, Xiao; Li, Qi; Li, Ping; Zhao, Gaonian; Xu, Mingming; Xie, Peng

doi:10.1007/s12013-011-9271-8

Cited by 44 publications

(31 citation statements)

References 13 publications

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“…Like to antitumor effects, it was observed different antiviral effects between quercetin and isoliquiritigenin [ 11 , 13 , 15 , 26 ]. Consistent with previous studies, our study also observed antiviral effects of quercetin and isoliquiritigenin.…”

Section: Discussionmentioning

confidence: 99%

“…Physical binding of GA to cohesion resulted in loss of significant roles of CTCF-Cohesin complex on transcription of KSHV latent transcript unit. Hung et al found that GA perfusion in Herpes simplex virus (HSV) infection greatly decreased adhesion and stress between rat cerebral capillary vessel endothelial cells (CCECs) and polymorphonuclear leukocytes (PMN), suggesting that GA may attenuate inflammatory responses in HSV infection [ 15 ]. Therefore, GA is likely to be a major bioactive compound responsible for protective effects of licorice against viral infections.…”

Section: Introductionmentioning

confidence: 99%

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Quercetin-induced apoptosis prevents EBV infection

et al. 2015

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Epstein-Barr virus (EBV) is a human gamma-1 herpesvirus that establishes a lifelong latency in over 90% of the world's population. During latency, virus exists predominantly as a chromatin-associated, multicopy episome in the nuclei of a variety of tumor cells derived from B cells, T cells, natural killer (NK) cells, and epithelial cells. Licorice is the root of Glycyrrhiza uralensis or G. glabra that has traditionally cultivated in eastern part of Asia. Licorice was reported to have anti-viral, anti-inflammatory, anti-atopic, hepatoprotective, anti-neurodegenerative, anti-tumor, anti-diabetic effects and so forth. Quercetin and isoliquiritigenin are produced from licorice and highly similar in molecular structure. They have diverse bioactive effects such as antiviral activity, anti-asthmatic activity, anti-cancer activity, anti-inflammation activity, monoamine-oxidase inhibitor, and etc. To determine anti-EBV and anti-EBVaGC (Epstein-Barr virus associated gastric carcinoma) effects of licorice, we investigated antitumor and antiviral effects of quercetin and isoliquiritigenin against EBVaGC. Although both quercetin and isoliquiritigenin are cytotoxic to SNU719 cells, quercetin induced more apoptosis in SNU719 cells than isoliquiritigenin, more completely eliminated DNMT1 and DNMT3A expressions than isoliquiritigenin, and more strongly affects the cell cycle progression of SNU719 than isoliquiritigenin. Both quercetin and isoliquiritigenin induce signal transductions to stimulate apoptosis, and induce EBV gene transcription. Quercetin enhances frequency of F promoter use, whereas isoliquiritigenin enhances frequency of Q promoter use. Quercetin reduces EBV latency, whereas isoliquiritigenin increases the latency. Quercetin increases more the EBV progeny production, and inhibits more EBV infection than isoliquiritigenin. These results indicate that quercetin could be a promising candidate for antiviral and antitumor agents against EBV and human gastric carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quercetin-induced apoptosis prevents EBV infection

et al. 2015

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“…Many in vitro experiments have shown that GC inhibits HCV by suppressing the release of infectious particles [57], inhibits HSV by depressing the cellular adhesion [58], inhibits influenza virus by reducing HMGB1 binding to DNA and suppressing interactions between viral macromolecules and host proteins [64], inhibits HIV by preventing the virus from replication [61], and inhibits H5N1 not by interfering with H5N1 replication, but by controling H5N1-induced proinflammatory gene expression [60]. The dispute about whether GC inhibits virus replication still needs further study.…”

Section: Antiviral Activitymentioning

confidence: 99%

The Pharmacological Activities of Licorice

et al. 2015

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!Licorice is one of the oldest and most frequently used herbs in traditional Chinese medicine. It contains more than 20 triterpenoids and 300 flavonoids. In recent years, a lot of studies have reported that the active compounds isolated from licorice possess antitumor, antimicrobial, antiviral, anti-inflammatory, immunoregulatory, and several other activities that contribute to the recovery and protection of the nervous, alimentary, respiratory, endocrine, and cardiovascular systems. In this paper, nine different pharmacological activities of licorice are summarized. The active compounds responsible for these pharmacological activities, the molecular mechanisms, and in vivo and in vitro studies are listed in detail. Furthermore, the clinical therapeutics and toxicity studies of licorice are also discussed. We hope this work can provide a basis for further studies concerning with the safe and effective use of licorice.

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“…Glycyrrhizin, a triterpene saponine, is a constituent of licorice root. Previous studies have demonstrated that glycyrrhizin has the ability to inhibit the proliferation of many viruses, such as hepatitis B virus (HBV) (Sato et al, 1996), hepatitis C virus (HCV) (Matsumoto et al, 2013), herpes simplex virus (HSV) (Huang et al, 2012), SARS coronavirus (Cinatl et al, 2003), and influenza viruses (Wolkerstorfer et al, 2009). In the present study, we aimed to assess the antiviral activity of glycyrrhizin against PRRSV and further elucidate the exact phase of the viral reproductive cycle that is affected by glycyrrhizin.…”

Section: Introductionmentioning

confidence: 99%

Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin

et al. 2015

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Glycyrrhizin is a natural component extracted from the roots of Glycyrrhiza glabra. In this study, we investigated the antiviral activity of glycyrrhizin against porcine reproductive and respiratory syndrome virus (PRRSV), an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. Our results showed that treatment with glycyrrhizin significantly reduced PRRSV proliferation and PRRSV-encoded protein expression in a dose-dependent manner. Mechanistically, glycyrrhizin mainly inhibits the penetration stage, and has little effect on the steps of adsorption or release of PRRSV in its life cycle. Furthermore, we were able to exclude a direct inhibitory action of glycyrrhizin on PRRSV particles. Given these results, glycyrrhizin may be a candidate component for a novel porcine reproductive and respiratory syndrome (PRRS) control strategy.

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Inhibition of Intercellular Adhesion in Herpex Simplex Virus Infection by Glycyrrhizin

Cited by 44 publications

References 13 publications

Quercetin-induced apoptosis prevents EBV infection

Quercetin-induced apoptosis prevents EBV infection

The Pharmacological Activities of Licorice

Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin

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