Inhibition of intracranial glioma growth by endometrial regenerative cells

Han, Xiudi; Meng, Xiaolong; Yin, Zhenglian; Rogers, Andrea; Zhong, Jie; Rillema, Paul; Jackson, James; Ichim, Thomas E.; Minev, Boris; Carrier, Ewa; Patel, Amit N.; Murphy, Michael P.; Wei, Min; Riordan, Neil H

doi:10.4161/cc.8.4.7731

Cited by 44 publications

(32 citation statements)

References 45 publications

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“…Moreover, to assess whether MenSCs modulate tumor growth, a rat glioma model was used. The injected cells showed a substantial inhibition of the tumor growth when compared to the control group (49). …”

Section: Safety Concerns and Clinical Applicationsmentioning

confidence: 88%

The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy

et al. 2014

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Menstrual-derived stem cells (MenSCs) are a new source of mesenchymal stem cells isolated from the menstrual fluid. Currently, there is a growing interest in their clinical potential due to fact that they are multipotent, highly proliferative, and easy to obtain in a non-invasive manner. Sampling can be repeated periodically in a simplified and reproducible manner devoid of complications that no existing cell source can match. MenSCs are also free of ethical dilemmas, and display novel properties with regard to presently known adult derived stem cells. This review details their distinctive biological properties regarding immunophenotype and function, proliferation rate, differentiation potential, and paracrine effects mediated by secreted factors. Their possible role in antenatal diagnosis is also discussed. While more insight on their immunomodulatory and diagnostic properties is needed, the impact of clinical and epidemiological factors, such as age, use of contraceptives, or hormonal status still requires further investigations to properly assess their current and future use in clinical application and diagnosis.

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Section: Safety Concerns and Clinical Applicationsmentioning

confidence: 88%

The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy

et al. 2014

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“…In comparison to other stem cell types, they have shown some advantages that make them a considerable source in cell therapy. Some advantages are immunosuppressive potential [15] and higher clonogenisty (1.25 %) in comparison with umbilical cord blood stem cells (UCBSCs), and no shown development of teratoma unlike embryonic stem cells [16,17]. Earlier studies have demonstrated their differentiation ability toward neuron-like cells [18][19][20] and oligodendrocyte [21].…”

Section: Introductionmentioning

confidence: 99%

Chimeric Self-assembling Nanofiber Containing Bone Marrow Homing Peptide’s Motif Induces Motor Neuron Recovery in Animal Model of Chronic Spinal Cord Injury; an In Vitro and In Vivo Investigation

et al. 2015

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To date, spinal cord injury (SCI) has remained an incurable disaster. The use of self-assembling peptide nanofiber containing bioactive motifs such as bone marrow homing peptide (BMHP1) as an injectable scaffold in spinal cord regeneration has been suggested. Human endometrial-derived stromal cells (hEnSCs) have been approved by the FDA for clinical application. In this regard, we were interested in investigating the role of BMHP1 in hEnSCs' neural differentiation in vitro and evaluating the supportive effects of this scaffold in rat model of chronic SCI. 1,1-Diphenyl-2-picryl-hydrazyl (DPPH), lactate dehydrogenase (LDH) release, 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay, real-time PCR, and immunocyotochemistry (ICC) were performed as a biocompatibility and neural differentiation evaluations on neuron-like hEnSC-derived cells encapsulated into nanofiber. Nanofiber was implanted into rats and followed by behavioral test, Nissl, luxol fast blue (LFB) staining and immunohistostaining (IHC). Results indicated that cell membrane of neuroblastoma cells were more sensitive than hEnSCs to concentration of proton and cell proliferation decreased with increase of concentration. This effect might be related to oxygen tension and elastic modules of scaffold. -BMHP1 nanofiber induced neural differentiation in hEnSC and decreased GFAP gene and protein as a marker of reactive astrocytes in vitro and in vivo. A reason for this finding might be related to the role of spacer number in induction of mechano-transduction signals. The presented study revealed the chimeric BMHP1 nanofiber induced higher axon regeneration and myelniation around the cavity and motor neuron function was encouraged to improve with less inflammatory response following SCI in rats. These effects were possibly due to nanostructured topography and mechano-transduction signals derived from hydrogel at low concentration.

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“…Subsequently, NSCs, MSCs, endothelial, hematopoietic, skinderived, and endometrial precursor cells have been utilized as migratory cellular vectors to tumors. [18][19][20][21][22][23] The first evidence of the tropism of MSCs to gliomas was demonstrated by implantation of rat MSCs into rats bearing syngeneic gliomas. 20 Intracranially implanted MSCs were found to migrate to and disperse throughout the tumor mass.…”

Section: Mscsmentioning

confidence: 99%

Toward Brain Tumor Gene Therapy Using Multipotent Mesenchymal Stromal Cell Vectors

2010

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Gene therapy of solid cancers has been severely restricted by the limited distribution of vectors within tumors. However, cellular vectors have emerged as an effective migratory system for gene delivery to invasive cancers. Implanted and injected multipotent mesenchymal stromal cells (MSCs) have shown tropism for several types of primary tumors and metastases. This capacity of MSCs forms the basis for their use as a gene vector system in neoplasms. Here, we review the tumor-directed migratory potential of MSCs, mechanisms of the migration, and the choice of therapeutic transgenes, with a focus on malignant gliomas as a model system for invasive and highly vascularized tumors. We examine recent findings demonstrating that MSCs share many characteristics with pericytes and that implanted MSCs localize primarily to perivascular niches within tumors, which might have therapeutic implications. The use of MSC vectors in cancer gene therapy raises concerns, however, including a possible MSC contribution to tumor stroma and vasculature, MSC-mediated antitumor immune suppression, and the potential malignant transformation of cultured MSCs. Nonetheless, we highlight the novel prospects of MSC-based tumor therapy, which appears to be a promising approach.

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Inhibition of intracranial glioma growth by endometrial regenerative cells

Cited by 44 publications

References 45 publications

The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy

The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy

Chimeric Self-assembling Nanofiber Containing Bone Marrow Homing Peptide’s Motif Induces Motor Neuron Recovery in Animal Model of Chronic Spinal Cord Injury; an In Vitro and In Vivo Investigation

Toward Brain Tumor Gene Therapy Using Multipotent Mesenchymal Stromal Cell Vectors

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