Inhibition of IRE1 modifies hypoxic regulation of G6PD, GPI, TKT, TALDO1, PGLS and RPIA genes expression in U87 glioma cells

Minchenko, О. H.; Garmash, I. A.; Minchenko, Dmytro O.

doi:10.15407/ubj89.01.038

Cited by 3 publications

(2 citation statements)

References 36 publications

(67 reference statements)

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“…Evidence has indicated that changes to the microenvironment resulting from hypoxia, which is insufficient to maintain cellular function, were associated with cancer pathology. In glioma cells, hypoxia decreased the gene expression of NCOA1 (55). It is known that Helicobacter pylori is responsible for gastric inflammation and gastric malignancy, which causes general inflammatory stress within the gastric mucosa, activating multiple oncogenic pathways and inducing epigenetic alterations, including histone modifications (56).…”

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 99%

Comprehensive analysis of histone modification‑associated genes on differential gene expression and prognosis in gastric cancer

et al. 2019

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Accumulating evidence suggests that the epigenetic alterations caused by histone modifications have important roles in the genesis of gastric cancer (GC), particularly the well-studied acetylation and methylation modifications. In the present study, a Bioinformatics analysis of the expression of histone modification-associated genes in GC and normal tissues was performed by using datasets from Oncomine, the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). The clinical data of GC patients were downloaded from TCGA to determine the association between histone modification-associated gene expression and clinicopathological parameters or survival of GC. Finally, lysine acetyltransferase 2A (KAT2A), nuclear receptor coactivator 1 (NCOA1), SMYD family member 5 (SMYD5), protein arginine methyltransferase 1 (PRMT1) and PRDF1-RIZ (PR)/Su(var)3-9, enhancer-of-zeste and trithorax (SET) domain 16 (PRDM16) were screened; KAT2A, SMYD5 and PRMT1 were upregulated, while PRDM16 expression was downregulated in GC. Analysis of the GEO and Oncomine datasets revealed that NCOA1 was upregulated, which was contrary to the result obtained with the TCGA stomach adenocarcinoma dataset. Aberrant expression of KAT2A, NCOA1, SMYD5 and PRMT1 was more obvious in gastric intestinal-type adenocarcinoma; low NCOA1 expression was associated with better overall survival of GC patients [hazard ratio (HR)=0.690, 95% CI=0.570-0.840, P<0.001] and was an independent predictor for patients diagnosed with GC (HR=0.639, 95% CI=0.437-0.933, P=0.020). Correlation analysis and protein-protein interaction network analysis indicated a close association between ATAD2 and estrogen receptor 1 (ESR1), PRMT1, NCOA1 and KAT2A. In conclusion, differential expression of KAT2A, NCOA1, SMYD5, PRMT1 and PRDM16 was identified in GC vs. normal tissues, low NCOA1 expression was associated with poor survival of GC and ATAD2 may interact with ESR1 to regulate NCOA1 and PRMT1 in GC.

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Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 99%

Comprehensive analysis of histone modification‑associated genes on differential gene expression and prognosis in gastric cancer

et al. 2019

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“…It has been shown that the expression of G6PD in tumor cells is higher compared with that in normal cells, and its expression is associated with the overall survival of tumor patients (2,5). Numerous studies have also demonstrated increased G6PD activity in several types of cancer, including bladder cancer, carcinoma of the endometrium, prostate cancer, kidney cancer, stomach cancer, cholangiocarcinoma, colon adenocarcinoma, lung cancer, cervical cancer, carcinoma of the ovary, hepatocellular carcinoma (HCC), glioma, pancreatic cancer and melanoma (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Based on the findings of previous studies, the aim of the present review was to focus on the mechanism underlying the role of G6PD in tumorigenesis and tumor development, as G6PD is hypothesized to become a topic of increased interest with regards to cancer in the future.…”

Section: Introductionmentioning

confidence: 99%

Exploring the role of glucose‑6‑phosphate dehydrogenase in cancer (Review)

Wang

Yang

et al. 2020

Oncol Rep

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Glucose-6-phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme found in human erythrocytes that provides reduced NADPH for cell metabolism. Glutathione produced by the G6PD pathway can reduce the degree of harm caused by reactive oxygen species such as oxygen-containing free radicals, peroxides and lipid peroxides. Investigation of G6PD has long focused on hemolysis, jaundice and other diseases caused by defects in its function. However, increased mRNA expression levels of G6PD are predictive of adverse clinical outcomes in cancer patients, including increased drug resistance, migration or proliferation of tumor cells. Mutations in the G6PD gene affect protein expression and activity, and alters the balance of redox states, leading to disease. However, the association between G6PD and tumors is incompletely understood. The aim of the present review was to summarize the current body of knowledge on the role of G6PD in tumor progression and the possible regulatory mechanisms involved. It is hypothesized that G6PD will prove to be of value as a target of cancer treatment in the near future.

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Novel inhibitors of human glucose-6-phosphate dehydrogenase (HsG6PD) affect the activity and stability of the protein

Ramírez-Nava

Hernández-Ochoa

Navarrete‐Vázquez

et al. 2021

Biochimica et Biophysica Acta (BBA) - General Subjects

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Inhibition of IRE1 modifies hypoxic regulation of G6PD, GPI, TKT, TALDO1, PGLS and RPIA genes expression in U87 glioma cells

Abstract: We have studied the effect of hypoxia on the expression level of mRNA of the basic enzymes of pentosephosphate cycle (G6PD, TKT, TALDO1,

Cited by 3 publications

References 36 publications

Comprehensive analysis of histone modification‑associated genes on differential gene expression and prognosis in gastric cancer

Comprehensive analysis of histone modification‑associated genes on differential gene expression and prognosis in gastric cancer

Exploring the role of glucose‑6‑phosphate dehydrogenase in cancer (Review)

Novel inhibitors of human glucose-6-phosphate dehydrogenase (HsG6PD) affect the activity and stability of the protein

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