2001
DOI: 10.1159/000054926
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Inhibition of K<sup>+</sup>-Evoked Release of Rat Striatal 5-Hydroxytryptamine by an Atypical Antidepressant: Trazodone

Abstract: Using microdialysis, extracellular concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were determined in the striatum of rats. In rats given trazodone, m-chlorophenylpiperazine dihydrochloride, or imipramine, the concentrations of 5-HT were unchanged. 5-HIAA in trazodone- or imipramine-treated rats, however, was respectively, decreased to 80 or 65% of preinjections levels. When the potassium concentration (K+) was increased up to 150 mmol/l in the perfusate, the con… Show more

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