Inhibition of keratinocyte growth by different NepaleseZanthoxylum species

Kumar, Sunil; Müller, Klaus

doi:10.1002/(sici)1099-1573(199905)13:3<214::aid-ptr431>3.0.co;2-2

Cited by 14 publications

(6 citation statements)

References 23 publications

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“…Z. oxyphyllum has also been reported as stimulant, stomachic and sudorific, appetizer, and anthelmintic and removes pain, tumors, useful in gastric problem, headache, body ache, fever, cold and cough and also used for the purification of blood ( Anonymous, 2003 , Kanjilal, 1992 , Kirtikar and Basu, 1993 ). Extracts from the bark and root of Z. oxyphyllum have been reported to have antiproliferative activity against the growth of human keratinocytes ( Kumar and Muller, 1999 ).…”

Section: Introductionmentioning

confidence: 99%

High gene flow and genetic diversity in three economically important Zanthoxylum Spp. of Upper Brahmaputra Valley Zone of NE India using molecular markers

et al. 2014

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The genetic diversity in Zanthoxylum species viz. Zanthoxylum nitidum, Zanthoxylum oxyphyllum and Zanthoxylum rhesta collected from the Upper Brahmaputra Valley Zone of Assam (NE India) was amplified using 13 random amplified polymorphic DNA (RAPD) markers and 9 inter-simple sequence repeat (ISSR) markers. RAPD markers were able to detect 81.82% polymorphism whereas ISSR detected 98.02% polymorphism. The genetic similarities were analyzed from the dendrogram constructed by RAPD and ISSR fingerprinting methods which divided the 3 species of Zanthoxylum into 3 clear different clusters. The principle component analysis (PCA) was carried out to confirm the clustering pattern of RAPD and ISSR analysis. Analysis of molecular variance (AMOVA) revealed the presence of significant variability between different Zanthoxylum species and within the species by both RAPD and ISSR markers. Z. nitidum was found to be sharing a high degree of variation with the other two Zanthoxylum species under study. The Nei's gene diversity (h), Shannon's information index (I), observed number of alleles (na) and effective number of alleles (ne) were also found to be higher in ISSR markers (0.3526, 0.5230, 1.9802 and 1.6145) than in RAPD markers (0.3144, 0.4610, 1.8182 and 1.5571). The values for total genotype diversity for among population (HT), within population diversity (Hs) and gene flow (Nm) were more in ISSR (0.3491, 0.2644 and 1.5610) than RAPD (0.3128, 0.2264 and 1.3087) but the mean coefficient of gene differentiation (GST) was more in RAPD (0.2764) than ISSR (0.2426). A comparison of this two finger printing methods was done by calculating MR, EMI and MI. The correlation coefficient between data matrices of RAPD and ISSR based on Mantel test was found to be significant (r = 0.65612).

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Section: Introductionmentioning

confidence: 99%

High gene flow and genetic diversity in three economically important Zanthoxylum Spp. of Upper Brahmaputra Valley Zone of NE India using molecular markers

et al. 2014

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“…The methanolic extract of Zanthoxylum armatum has shown antiproliferative effect (Kumar and Muller, 1999). The essential oil of fruit of Zanthoxylum armatum exhibit antibacterial, antifungal and anthelmintic activities (Mehta et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological basis for the medicinal use of Zanthoxylum armatum in gut, airways and cardiovascular disorders

Gilani

Khan

Gilani

2009

Phytotherapy Research

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This study describes the gut, airways and cardiovascular modulatory activities of Zanthoxylum armatum DC. (Rutaceae) to rationalize some of its medicinal uses. The crude extract of Zanthoxylum armatum (Za.Cr) caused concentration-dependent relaxation of spontaneous and high K(+) (80 mM)-induced contractions in isolated rabbit jejunum, being more effective against K(+) and suggestive of Ca(++) antagonist effect, which was confirmed when pretreatment of the tissues with Za.Cr shifted Ca(++) concentration-response curves to the right, like that caused by verapamil. Za.Cr inhibited the castor-oil-induced diarrhea in mice at 300-1000 mg/kg. In rabbit tracheal preparations, Za.Cr relaxed the carbachol (1 microM) and high K(+)-induced contractions, in a pattern similar to that of verapamil. In isolated rabbit aortic rings, Za.Cr exhibited vasodilator effect against phenylephrine (1 microM) and K(+)-induced contractions. When tested in guinea pig atria, Za.Cr caused inhibition of both atrial force and rate of spontaneous contractions, like that caused by verapamil. These results indicate that Zanthoxylum armatum exhibits spasmolytic effects, mediated possibly through Ca(++) antagonist mechanism, which provides pharmacological base for its medicinal use in the gastrointestinal, respiratory and cardiovascular disorders.

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“…Antiproliferative activity was not due to the cytotoxic effects on cell membranes rather they protect against the radical-induced-damage to model membranes stimulated with 2,2´-azo-bis(2-amidinopropane) dihydrochloride. 52…”

Section: Antiproliferative Activitymentioning

confidence: 99%

A review on effective utilization, phytochemical compounds, pharmacological intervention of a popularly used plant for developing a new drug: Zanthoxylum armatum with reference to its anticancer activity

Barua

Yasmin

Elancheran

2018

MOJBB

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Traditionally it is used by the Bhotiya communities for food, medicines and exchange in the Uttaranchal, Himalaya of India. The Zanthoxylum armatum fruit is used by the Bhotiyas of Pithoragarh district of Kumaon region while those of the Kamoli district of Garhwal have developed the collection and trade of Z. armatum sticks to pilgrims visiting the shrines of Badrinath, Kedarnath, Gangotri and Yamunotri. 2 The fruits, bark and leaves are used as spice, in the Indian medicine system. Definition Zanthoxylum armatum known as winged prickly ash is a species of plant in the Rutaceae family. It is an aromatic deciduous, spiny shrub growing to 3.5 meters in height, endemic to China, Japan, Korea and India. Zanthoxylum armatum is a wild plant and mostly used as a condiment and medicine and have other medicinal properties.

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Inhibition of keratinocyte growth by different NepaleseZanthoxylum species

Cited by 14 publications

References 23 publications

High gene flow and genetic diversity in three economically important Zanthoxylum Spp. of Upper Brahmaputra Valley Zone of NE India using molecular markers

High gene flow and genetic diversity in three economically important Zanthoxylum Spp. of Upper Brahmaputra Valley Zone of NE India using molecular markers

Pharmacological basis for the medicinal use of Zanthoxylum armatum in gut, airways and cardiovascular disorders

A review on effective utilization, phytochemical compounds, pharmacological intervention of a popularly used plant for developing a new drug: Zanthoxylum armatum with reference to its anticancer activity

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