1944
DOI: 10.1136/bmj.2.4369.428
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Inhibition of Lactation by Hexoestrol Dipropionate

Abstract: JOURNALwas our practice to give the infant the same kind of food as he had had before admission unless there was some definite contraindication. Vitamins A, B, C, and D were added to the feeds from the first day, and continued throughout the stay in hospital.3. The early correction of fluid loss. Fluids and proteins were administered intravenously in the form of half-strength serum or plasma (diluted with Hartmann's solution) as soon as there was clinical evidence of dehydration, and in quantities sufficient t… Show more

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Cited by 2 publications
(2 citation statements)
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“…In the hexestrol series too, all previous reports agreed that esterification of the phenolic hydroxyl groups usually results in a loss of potency coupled with a prolongation of effect, as shown in table 6. Very recently it was reported by Prescott and Basden (153) that Brownlee found hexestrol dipropionate to be 1.5 to 3 times more potent than hexestrol when injected into rats. By mouth the dipropionate is less potent than hexestrol.…”
Section: CVImentioning
confidence: 96%
“…In the hexestrol series too, all previous reports agreed that esterification of the phenolic hydroxyl groups usually results in a loss of potency coupled with a prolongation of effect, as shown in table 6. Very recently it was reported by Prescott and Basden (153) that Brownlee found hexestrol dipropionate to be 1.5 to 3 times more potent than hexestrol when injected into rats. By mouth the dipropionate is less potent than hexestrol.…”
Section: CVImentioning
confidence: 96%
“…Various techniques are said to give good results. There is no need to review the literature in full, for this was done by Barnes (1942) and Prescott and Basden (1944). Some writers (Diddle, 1941 ;Gavioli, 1944) claim good results with a single dose of 5 or 10 mg. on the first day; others have been disappointed with the results of giving 35 mg.…”
Section: Trials With Stilboestrolmentioning
confidence: 99%