Inhibition of lecithin:Cholesterol acyltransferase following intravenous administration of heparin in man

Rutenberg, Harold L.; Lacko, Andras G.; Soloff, Louis A.

doi:10.1016/0005-2760(73)90142-2

Cited by 28 publications

(4 citation statements)

References 18 publications

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“…A decrease in serum LCAT has previously been reported in adults maintained on TPN for long periods of time (27,28). Our present study shows that in spite of low LCAT activity and apoprotein AI levels , serum cholesterol concentrations rema in within normal levels during the course of TPN.…”

Section: Discussionsupporting

confidence: 75%

Lecithin

Spear,

Amr,

Hamosh

et al. 1991

J. pediatr. gastroenterol. nutr.

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SummaryPlasma cholesterol and lecithin concentrations are regulated by the serum enzyme lecithin:cholesterol acyltransferase (LCAT). LCAT activity is low in cord blood of premature infants, suggesting that in these infants the hypercholesterolemia associated with Intralipid infusion might be due to low LCAT activity. The serum LCAT activity has not been quantitated in preterm infants receiving intravenous fat emulsions. We have therefore quantitated LCAT activity in eleven premature infants maintained on total parenteral nutrition (TPN). Ten infants were studied during the first 2 weeks after birth; they received daily infusions of Intralipid at a rate of 0.5–2.0 g/kg/day over 15 h. One infant received 3.8 g/kg/day during the second week. In addition to LCAT, serum apoprotein A1 (the cofactor of LCAT), cholesterol, triglycerides, and free fatty acids were quantitated. Blood specimens were taken before the start of the infusion and 15–45 min before its completion. The LCAT activity and apoprotein A1 concentrations remained, respectively, 21–24% and 30–35% of adult levels. However, serum cholesterol levels remained in the normal range during the fat infusion. It remains to be established whether low LCAT activity and apoprotein A1 levels are due to the administration of Intralipid (which lowers LCAT activity in rats), to the lack of enteral feedings, or to prematurity per se. Our data suggest that administration of Intralipid at a rate not exceeding 1–2 g/kg/day does not impair the clearing of Intralipid‐lecithin and the metabolism of cholesterol.

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Section: Discussionsupporting

confidence: 75%

Lecithin

Spear,

Amr,

Hamosh

et al. 1991

J. pediatr. gastroenterol. nutr.

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“…Dialysis treatment could, however, theoretically improve LCAT activity by causing structural changes in HDL or in its binding properties. There is no evidence that heparin treatment stimulates LCAT: indeed increases in plasma free fatty acid levels which would result from heparin actually inhibit LCAT [21]. It seems more likely that improved nutrition or chronic exposure to heparin resulting from dialysis could subtly alter the lipoproteins which modulate LCATs func tional capacity without changing its concentration.…”

Section: Discussionmentioning

confidence: 96%

Lecithin: Cholesterol Acyltransferase Activity in Dialyzed and Undialyzed Chronic Uremic Patients

Bories

Subbaiah²,

Bagdade

1982

Nephron

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Lecithin cholesterol acyltransferase (LCAT) and lysolecithin acyltransferase (LAT) activities in plasma were significantly lower in undialyzed than in dialyzed uremic patients and controls. Both LCAT and LAT activities were normal in the maintenance dialysis group. The free/total cholesterol ratio was significantly increased in the undialyzed patients only. This ratio and LCAT were inversely related in the dialyzed group, unrelated in the undialyzed patients, and positively correlated in controls. Unlike non-uremic populations with hypertriglyceridemia in which LCAT is increased, no correlation was found between plasma triglyceride and LCAT in the uremic population studied. Our results show that both LCAT and LAT activities are reduced in undialyzed chronic uremic patients but are not significantly different from control levels in patients treated with chronic hemodialysis. These results indicate that the changes in LCAT activity contrast with those described in lipoprotein composition and metabolism which do not appear to be affected by chronic dialysis therapy.

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“…Thus, Chan et al 21 showed that LCAT activity in hemodialysis patients, already low, was further decreased by dialysis, and this effect was attributed to inhibition by fatty acids, the concentration of which increases because of heparinization. 34 Other studies indicate that the direct effect of hemodialysis has been to increase LCAT activity slightly when measured with the endogenous lipoproteins acting as substrates, but not with exogenous lipoprotein substrates. 23 In this latter study and in those of Bories et al 22 and Walker et al, 31 LCAT activity measured with endogenous lipoprotein substrates was not significantly different from controls.…”

Section: Discussionmentioning

confidence: 99%

Levels of Cholesteryl Esters and Other Lipids in the Plasma of Patients with End-Stage Renal Failure

Gillett

Obineche

Lakhani

et al. 2001

Annals of Saudi Medicine

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Background:The importance of plasma lipid abnormalities in chronic renal failure (CRF) is well recognized, but surprisingly little attention has been given to the study of some plasma lipid fractions, including cholesteryl esters (CE) and phospholipids, which might be expected to be important factors in the pathogenesis of the disease. Materials and Methods: Fasting blood samples were taken from 25 control subjects and 53 CRF patients (29 predialysis and 24 on hemodialysis). Samples were analyzed for urea nitrogen, creatinine, triacylglycerols, total and individual phospholipids, total and free cholesterol, as well as cholesterol bound to very low-, low-and high-density lipoproteins (VLDL, LDL and HDL). Plasma CE was calculated and expressed as a percentage of total cholesterol. Results: Over half of the patients had CE levels more than two standard deviations below the control value. In this subgroup of low CE patients, total, LDL-and HDL-cholesterol levels were also significantly lower than for controls, while levels of phosphatidylcholine and lysophosphatidylcholine were decreased and increased, respectively. In patients with high CE, no significant lipid abnormalities were observed. Conclusion: In this study, CE was an excellent marker for lipid disturbances-if CE was high, then the other lipid fractions were normal, but if CE was low, most other lipid fractions were abnormal. The changes noted appear to be consequences of or related to deficiency of the plasma enzyme lecithin-cholesterol acyltransferase. Ann Saudi Med 2001;21(5-6):283-286.

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Inhibition of lecithin:Cholesterol acyltransferase following intravenous administration of heparin in man

Cited by 28 publications

References 18 publications

Lecithin

Lecithin

Lecithin: Cholesterol Acyltransferase Activity in Dialyzed and Undialyzed Chronic Uremic Patients

Levels of Cholesteryl Esters and Other Lipids in the Plasma of Patients with End-Stage Renal Failure

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