1972
DOI: 10.1038/newbio238051a0
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Inhibition of Leukaemia Virus Replication by Polyadenylic Acid

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Cited by 42 publications
(17 citation statements)
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“…If this system is to be analogous to that reported for the oncornaviruses (8,16,19,21), then (dUfl)n should inhibit the activity ofthe virus-encapsulated nucleic acid polymerase. Purified B particles were solubilized by the high salt method of Emerson and Wagner (6) and assayed for RNA polymerase activity using the endogenous viral genome as template.…”
Section: Resultsmentioning
confidence: 99%
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“…If this system is to be analogous to that reported for the oncornaviruses (8,16,19,21), then (dUfl)n should inhibit the activity ofthe virus-encapsulated nucleic acid polymerase. Purified B particles were solubilized by the high salt method of Emerson and Wagner (6) and assayed for RNA polymerase activity using the endogenous viral genome as template.…”
Section: Resultsmentioning
confidence: 99%
“…This area of investigation gained additional impetus with the simultaneous development of a number of nuclease-resistant forms of synthetic polynucleotides including (1-vinyluracil), and (9-vinyladenine)n (16), (2'-O-methyladenylic acid), (21), and (dUfl)n (8), all of which have been found to inhibit oncornavirus DNA polymerase activity.…”
Section: Resultsmentioning
confidence: 99%
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“…The inhibitory properties of (U)n are markedly enhanced by modification at the 2' position (3,4). It also has been reported that the replication of Moloney leukemia virus in cell cultures of NIH Swiss strain embryo cells is inhibited by (A)n (5). In addition, several studies have shown that AMV RNA-dependent DNA polymerase contains sulfhydryl groups, which are sensitive to modification by hydrophobic sulfhydryl reagents (6) and…”
mentioning
confidence: 93%
“…However, cytosine arabinoside, which also blocks DNA synthesis, had no effect (Table 3). Cordycepin and polyadenylic acid, which block MuLV replication (24,25), were both strongly inhibitory (Table 3 (Fig. 1).…”
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confidence: 99%