Inhibition of Leukotriene Generation by a Gum Resin Exudate ofBoswellia serratain Rat Peritoneal Leukocytes

Abstract

Studies with various immunological models of inflammation revealed that the root extract possesses significant activity against carrageenin-induced pleurisy (10), contact and delayed hypersensitivity with picryl chloride (11), and delayed hypersensitivity reactions with oxazolone (12). SG and the ethanolic extract of Salai Guggal ex Boswellia serrata did not affect cell viability and did not stimulate 5-LOx product formation per se in the absence of calcium-ionophore. In conclusion, our findings indicate that SG inhibits leukotriene-generation in vitro. The results obtained thus suggest that the methanolic fraction of P. indica root extract possesses significant anti-inflammatory and anti-arthritic action (Table 1).