Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-κB axis

Cao, Hua; Han, Xuan; Jia, Yonglin; Zhang, Baohua

doi:10.18632/aging.202837

Cited by 30 publications

(18 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HOXA11-AS long non-coding RNA mediated neuronal injury in MPTP cellular model of PD and LPS-induce microglia activation, but miR-124 has opposite effect. HOXA11-AS over-expression increases expression of inflammatory factor and FSTL1, NF-kB and NLRP3 inflammasome while miR-124 is the target of HOXA11-AS and FSTL1 (39). KLF4 and NEAT1 are upregulate in the midbrain of MTPT-HCl mice.…”

Section: Resultsmentioning

confidence: 99%

Evaluation role of miR-124 in neurodegenerative diseases: literature review and in silico analysis

Amini

Bibak

Afshar

et al. 2021

Preprint

View full text Add to dashboard Cite

Neurodegenerative diseases (ND) are characterized by loss of function and structure of neurons. NDs like Alzheimer's disease (AD) and Parkinson's disease (PD) have high burden on the society and patients. Currently microRNAs (miRNAs) approach is growing. miRNAs express in different tissues, especially in the central neuron systems (CNS). miRNAs have a dynamic role in the CNS among this miRNAs, miR-124 significantly express in the CNS. Studies on miR-124 have shown that miR-124 improves ND. In this study, we evaluated the role of miR-124 in the ND by literature review and in silico analysis. We used Pubmed database to find miR-124 function in the Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Huntington's disease and amyotrophic lateral sclerosis. To better understand the role of miR-124 in the neurons, RNA-seq data form miR-124-deleted neuronal cells extracted from GEO database and analyzed in Galaxy platform. According literature review miR-124 attenuates inflammation and apoptosis in the ND by target NF-kb signaling pathway and regulation of BAX/BCL-2. miR-124 targets BACE1 and decreases level of Aβ. RNA-seq data showed miR-124 downregulation, an increase in chemokine gene like CCL1 and cytokine-cytokine receptor-interaction, as well as MAPK-signaling pathway. Our study shows that miR-124 can be promising therapeutic approaches to ND.

show abstract

Section: Resultsmentioning

confidence: 99%

Evaluation role of miR-124 in neurodegenerative diseases: literature review and in silico analysis

Amini

Bibak

Afshar

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…In this review, the lncRNA/circRNA-miRNA-mRNA regulatory network also exists in microglia and astrocyte mediated neurological diseases, including SCI (Figure 1; Shao et al, 2020; FIGURE 1 | The lncRNA/circRNA-miRNA-mRNA regulatory network in microglia and astrocyte regulated neurological diseases. Xu S. et al, 2020;Zhao Q. et al, 2020;Cui et al, 2021;Xiang et al, 2021;Chen et al, 2022), TBI (He et al, 2021;Liu N. et al, 2021;Meng et al, 2021), cerebral IRI (Figure 1; Wang et al, 2020c;Yang et al, 2021), stroke (Figure 1; Qi et al, 2017;Han B. et al, 2018;Tian et al, 2021;Zhang M. et al, 2021), epilepsy (Figure 1; Feng et al, 2020;Han C. L. et al, 2020;Wan and Yang, 2020;Xiaoying et al, 2020), neuropathic pain (Figure 1; Chen M. et al, 2020), PD (Figure 1; Cao et al, 2018Cao et al, , 2021, and depression (Figure 1; . We also found that some therapies can impair the ncRNA-glial cell axis and thus inhibit disease development.…”

Section: Discussionmentioning

confidence: 99%

“…LncRNA HOXA11-AS is detected to be up-regulated in the substantia nigra area in PD mice. HOXA11-AS over-expression can elevate the levels of inflammatory factors, including, IL-1β, IL-18, IL-6, and TNFα in LPS-mediated BV2 cells (Cao et al, 2021). HOXA11-AS can target miR-124-3p that can target follistatin-like 1 (FSTL1).…”

Section: Parkinson's Diseasementioning

confidence: 99%

“…The inactivation of the FSTL1/NF-κB pathway can dampen neuron damage and inhibit microglial inflammation. Ultimately, HOXA11-AS downregulation mitigates PD progression in PD mice (Cao et al, 2021). MALAT1 highly expresses in 1-Methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP)-induced PD mouse brain tissues and in and in LPS/ATP-induced BV2 cells.…”

Section: Parkinson's Diseasementioning

confidence: 99%

See 1 more Smart Citation

Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Chen

Lai

Wang

et al. 2021

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia and astrocytes have pro-inflammatory phenotype and anti-inflammatory phenotype. Activated microglia and activated astrocytes can contribute to several neurological diseases. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), two groups of non-coding RNAs (ncRNAs), can function as competing endogenous RNAs (ceRNAs) to impair the microRNA (miRNA) inhibition on targeted messenger RNAs (mRNAs). LncRNAs and circRNAs are involved in various neurological disorders. In this review, we summarized that lncRNAs and circRNAs participate in microglia dysfunction, astrocyte dysfunction, neuron damage, and inflammation. Thereby, lncRNAs and circRNAs can positively or negatively regulate neurological diseases, including spinal cord injury (SCI), traumatic brain injury (TBI), ischemia-reperfusion injury (IRI), stroke, neuropathic pain, epilepsy, Parkinson’s disease (PD), multiple sclerosis (MS), and Alzheimer’s disease (AD). Besides, we also found a lncRNA/circRNA-miRNA-mRNA regulatory network in microglia and astrocyte mediated neurological diseases. Through this review, we hope to cast light on the regulatory mechanisms of lncRNAs and circRNAs in microglia and astrocyte mediated neurological diseases and provide new insights for neurological disease treatment.

show abstract

“…As long-term hyperglycemia induces inflammatory response, vascular and target organs damage occurs ( Nolan et al, 2011 ), ultimately increasing the incidence of tumors ( Shikata et al, 2013 ; Singh et al, 2021 ), cardiovascular and cerebrovascular diseases ( Kozakova et al, 2019 ; Eckel et al, 2021 ), and other infections ( D'Elia et al, 1991 ; Knapp, 2013 ; Fang et al, 2021 ). NLRP3 inflammasome regulation by lncRNAs is a current research hotspot and has been widely documented in many diseases, such as inflammatory bowel diseases ( Samoilă et al, 2020 ), Parkinson’s disease ( Haque et al, 2020 ; Cao et al, 2021 ), and cancer ( Farooqi et al, 2020 ; Tang et al, 2020 ). Studies indicate that lncRNAs and NLRP3 inflammasome are overexpressed in diabetes complications, implying that lncRNAs could cause inflammatory responses by activating NLRP3 inflammasome ( Hu et al, 2019 ; Farooqi et al, 2020 ; Liu et al, 2020 ).…”

Section: The Mechanism Of Lncrna Involved In Nlrp3 Inflammasome Regulationmentioning

confidence: 99%

Emerging Role of LncRNA Regulation for NLRP3 Inflammasome in Diabetes Complications

Lü

Tan

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Diabetes is a widespread metabolic disease with various complications, including diabetic nephropathy, retinopathy, cardiomyopathy, and other cardiovascular or cerebrovascular diseases. As the prevalence of diabetes increases in all age groups worldwide, diabetes and its complications cause an emerging public health burden. NLRP3 inflammasome is a complex of several proteins that play a critical role in inflammatory response and various diseases, including diabetes and its complications. Accumulating evidences indicate that NLRP3 inflammasome contributes to the development of diabetes and diabetic complications and that NLRP3 inflammation inactivation is beneficial in treating these illnesses. Emerging evidences suggest the critical role of long non-coding RNAs (lncRNAs) in regulating NLRP3 inflammasome activity in various diseases. LncRNAs are non-coding RNAs exceeding 200 nucleotides in length. Its dysregulation has been linked to the development of diseases, including diabetes. Recently, growing evidences hint that regulating lncRNAs on NLRP3 inflammasome is critical in developing and progressing diabetes and diabetic complications. Here, we discuss the role of lncRNAs in regulating NLRP3 inflammasome as well as its participation in diabetes and diabetic complications, providing novel insights into developing future therapeutic approaches for diabetes.

show abstract

Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-κB axis

Cited by 30 publications

References 37 publications

Evaluation role of miR-124 in neurodegenerative diseases: literature review and in silico analysis

Evaluation role of miR-124 in neurodegenerative diseases: literature review and in silico analysis

Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Emerging Role of LncRNA Regulation for NLRP3 Inflammasome in Diabetes Complications

Contact Info

Product

Resources

About