2016
DOI: 10.1210/en.2016-1406
|View full text |Cite
|
Sign up to set email alerts
|

Inhibition of Lysyl Oxidase by Cortisol Regeneration in Human Amnion: Implications for Rupture of Fetal Membranes

Abstract: The mechanisms underlying human parturition are still not understood, yet we need this knowledge to combat preterm birth. Fetal membranes express abundant 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which converts inert cortisone to active cortisol. We examined whether cortisol regeneration in the amnion might play a role in human parturition through regulation of lysyl oxidase (LOX), a collagen cross-linking enzyme, thereby contributing to the rupture of fetal membranes. By using cultured human primary amn… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

2
27
1

Year Published

2017
2017
2021
2021

Publication Types

Select...
6
1

Relationship

4
3

Authors

Journals

citations
Cited by 26 publications
(30 citation statements)
references
References 36 publications
2
27
1
Order By: Relevance
“…Since the abundance of SAA1 is increased significantly in the amnion tissue following labor, we believe that the production of SAA1 by amnion fibroblasts may participate in human parturition by stimulating the production of inflammation mediators in the amnion tissue. Although the effect of labor on SAA1 abundance can be either a cause or effect of labor, we believe that the increases in SAA1 abundance in the amnion tissue occur before labor and are further enhanced during labor since the expression of SAA1 is under the up-regulation of glucocorticoids, and it is known that the regeneration of cortisol by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) is increasing with gestational age 32 and is further exaggerated during labor in the amnion 28, 33, 34 .…”
Section: Discussionmentioning
confidence: 98%
“…Since the abundance of SAA1 is increased significantly in the amnion tissue following labor, we believe that the production of SAA1 by amnion fibroblasts may participate in human parturition by stimulating the production of inflammation mediators in the amnion tissue. Although the effect of labor on SAA1 abundance can be either a cause or effect of labor, we believe that the increases in SAA1 abundance in the amnion tissue occur before labor and are further enhanced during labor since the expression of SAA1 is under the up-regulation of glucocorticoids, and it is known that the regeneration of cortisol by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) is increasing with gestational age 32 and is further exaggerated during labor in the amnion 28, 33, 34 .…”
Section: Discussionmentioning
confidence: 98%
“…As collagen IV is essential for the maintenance of epithelial basal membrane and in the assembling of other ECM structural proteins in the amnion (10,46,47), the induction of MMP7 expression by cortisol and the degradation of COL4A5 by MMP-7 are additional evidence of cortisol regeneration in ECM remodeling in the amnion, in addition to the autophagic and proteasomic degradation of collagen I and III (8,9) and inhibition of collagen crosslinking enzyme lysyl oxidase demonstrated previously (7). Of note, increased apoptosis of the amnion epithelial layer has been shown to be another contributor to membrane rupture (29,48).…”
Section: Discussionmentioning
confidence: 79%
“…These data suggest that the increase in MMP-7 abundance and decrease in CO-L4A5 abundance in the amnion tissue may be associated with the spontaneous rupture of membranes at parturition. Given that there is increased 11b-HSD1 abundance and cortisol regeneration in the amnion tissue at parturition (7) and the drastic induction of MMP7 expression by cortisol, it is likely that these reciprocal changes of MMP-7 and COL4A5 in the amnion tissue in spontaneous rupture of membranes at parturition are, at least in part, a result of the consequence of an increase of cortisol accumulation in the amnion.…”
Section: Role Of Ap-1 In the Induction Of Mmp-7 By Cortisolmentioning
confidence: 99%
See 2 more Smart Citations