Inhibition of macrophage-induced antigen-specific T lymphocyte proliferation by poly I:C: Strain and antigen independence

Kirschmann, Dawn A.; Murasko, Donna M.

doi:10.1016/0008-8749(91)90250-f

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…Macrophages exposed to activating agents such as mitogens, IFN-γ and LPS can inhibit both mitogen-and antigen-specific T-cell proliferation. This inhibition can be mediated by soluble substances such as prostaglandin E 2 , direct cell contact with T cells, or by the induction of suppressing cytotoxic T cells (Kirschmann et al, 1994;McKernan et al, 1988). It was shown that H. pylori LPS expressed a very weak, if any, capacity to stimulate the proliferation of tPBML from dyspeptic patients (Rudnicka et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Antigen-specific lymphocyte proliferation as a marker of immune response in guinea pigs with sustained Helicobacter pylori infection.

et al. 2014

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Helicobacter pylori (H. pylori) bacteria are human pathogens causing symptomatic gastritis, peptic ulcer or gastric cancer. Little is known about the kinetics of immune responses in H. pylori infected patients because the initial moment of infection has not been identified. Various animal models are used to investigate the immune processes related to H. pylori infection. In this study we checked whether H. pylori infection in guinea pigs, mimicking natural H. pylori infection in humans, resulted in the development of specific immune responses to H. pylori antigens by measuring the proliferation of lymphocytes localized in mesenteric lymph nodes, spleen and peripheral blood. The maturity of macrophages and cytokines, delivered by monocyte-macrophage lineage or lymphocytes, were considered as mediators, which might influence the lymphocyte blastogenic response. The obtained results showed the activation of T cells localized in mesenteric lymph nodes by H. pylori antigens in H. pylori infected guinea pigs four weeks postinfection. The blastogenic activity of lymphocytes was shaped by their interaction with antigen presenting cells, which were present in the cell cultures during the whole culture period. Moreover, the balance between cytokines derived from adherent leukocytes including interleukin 8--IL-8 as well as interferon gamma--IFN-γ, and transforming growth factor beta--TGF-β delivered by lymphocytes, was probably important for the successful proliferation of lymphocytes. The H. pylori specific lymphocytes were not propagated in peripheral blood and spleen of H. pylori infected animals. The modulation of immunocompetent cells by H. pylori antigens or their different distribution cannot be excluded.

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Section: Discussionmentioning

confidence: 99%

Antigen-specific lymphocyte proliferation as a marker of immune response in guinea pigs with sustained Helicobacter pylori infection.

et al. 2014

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“…In these situations, it seems reasonable to consider whether changes in tissue custocyte density or distribution might account for an enhanced suppressor custocyte activity. Antigenspecific suppressive actions of custocytes have less often been reported [121][122][123]. T 'suppressor' cell induction has been shown to be preferentially induced by certain bone marrow-derived custocyte populations in contact hypersensitivity [124][125][126][127].…”

Section: 'No Inflammation Without Custocytes'mentioning

confidence: 99%

The mononuclear phagocyte–dendritic cell dichotomy: myths, facts, and a revised concept

Goerdt

Kodelja

Schmuth

et al. 1996

Clinical and Experimental Immunology

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SUMMARYSince Aschoff 's reticuloendothelial system was abandoned a few decades ago, classification and characterization of the mononuclear phagocyte and dendritic cell systems have evolved separately or even in competition with one another. New information has now become available indicating that monocytes/macrophages and dendritic cells have a common origin in the bone marrow, and may even transdifferentiate. Morphological and functional distinctions-although valid under certain conditions-have been blurred by revelation of the versatility of monocytes/macrophages and dendritic cells in response to different contextual needs in inflammation and immunity. Monocytes/macrophages and dendritic cells share a sentinel, receptor/effector, and presentation mode, and may either activate or silence specific immune reactions. In keeping with the view of monocytes/macrophages and dendritic cells as interactive sentinels, we suggest that the mononuclear phagocyte and dendritic cell systems be replaced by the custocyte system (custos, Lat sentinel, guard) as a unifying concept. Within the custocyte system, we recognize type I, type II, and type III custocytes. Type I and II custocytes exhibit predominance of presentation or effector/presenter interdependency, respectively, while type III custocytes are bipolar, passing through type I-and type II-like phases during their development and in inflammatory responses. The custocyte system brings into view monocytes/macrophages and dendritic cells as dynamic players in immunity and inflammation with a high degree of derivational, phenotypic, functional, and molecular plasticity.

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“…Соотношение Th1/Th2 цитоки нов в свою очередь определяет особенности акти вации макрофагов. При стимуляции IFN γ (клас сический путь активации) макрофаги продуциру ют провоспалительные цитокины, поддерживаю щие Th1 ответ, тогда как при стимуляции IL 4 (альтернативная активация) противовоспали тельные цитокины и, соответственно обладают суп рессорной активностью в отношении клеточных реакций [16,12].…”

Section: Introductionunclassified

Cytokine Profile in Patients With Chronic Virus Hepatitis Complicated With Fibrosis and Cirrhosis

Черных¹,

Старостина²,

Леплина³

et al. 2014

Med. immunol.

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Резюме. В работе проведен сравнительный анализ спонтанной и LPS стимулированной продукции цитокинов, характеризующих баланс Th1/Th2 (IFN γ/IL 4, IL 13), а также про и противовоспалитель ную активность моноцитов (TNF α/IL 10) в культурах клеток крови здоровых доноров и больных хрони ческими вирусными гепатитами с наличием фиброза и цирроза печени. Показано, что клетки перифери ческой крови обследованных больных характеризуются выраженным усилением цитокин продуцирую щей функции, что проявляется высоким уровнем спонтанной и индуцированной продукции как Th1/про воспалительных, так и Th2/противовоспалительных цитокинов. При этом трансформация в цирроз связа на с усилением спонтанной продукции IL 4 и IL 13 и прогрессирующим возрастанием спонтанной про дукции IFN γ, TNF α и IL 10. В свою очередь утяжеление цирроза ассоциируется с нарастанием выражен ности воспалительной активности крови и снижении противовоспалительного потенциала. Так, больные с циррозом печени класса С характеризуются значительно более высокими индексами соотношения TNF α/IL 10 и IFN γ/IL 10, чем больные с циррозом класса А. Кроме того была выявлена прямая взаимосвязь индекса TNF α/IL 10 с интенсивностью цитолиза и тяжестью цирроза (баллом по Child Pugh) и обратная связь между тяжестью цирроза и индексом LPS стимуляции IL 10. Доминирование провоспалительных цитокинов, проявляющееся в увеличении индекса соотношения IFN γ/IL 10 ассоциировано также с нали чием анемии. Таким образом, особенности продукции цитокинов клетками крови при хронической вирус ной инфекции у больных с фиброзом и циррозом печени отражают характер клинического течения забо левания. CYTOKINE PROFILE IN PATIENTS WITH CHRONIC VIRUS HEPATITIS COMPLICATED WITH FIBROSIS AND CIRRHOSISAbstract. In present study, a comparative analysis of spontaneous and LPS stimulated production of Th1/ Th2 (IFN γ/IL 4, IL 13), and monocyte derived pro and anti inflammatory cytokines (TNF α/IL 10) was carried out in blood cell cultures of healthy donors and the patients with chronic viral hepatitis complicated with liver fibrosis and cirrhosis. The patients' cells exhibited an increased production of both Th1/proinflammatory and Th2/anti inflammatory cytokines. Meanwhile, hep atitis induced cirrhotic transformation correlates with enhancement of spontaneous IL 4 and IL 13 production (not observed in fibrosis patients), and progressive in crease of spontaneous IFN γ, TNF α and IL 10 secre tion. In turn, the progression of cirrhosis is connected with increase of pro inflammatory blood activity and reduction of anti inflammatory potential. E.g., the pa

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Inhibition of macrophage-induced antigen-specific T lymphocyte proliferation by poly I:C: Strain and antigen independence

Cited by 6 publications

References 28 publications

Antigen-specific lymphocyte proliferation as a marker of immune response in guinea pigs with sustained Helicobacter pylori infection.

Antigen-specific lymphocyte proliferation as a marker of immune response in guinea pigs with sustained Helicobacter pylori infection.

The mononuclear phagocyte–dendritic cell dichotomy: myths, facts, and a revised concept

Cytokine Profile in Patients With Chronic Virus Hepatitis Complicated With Fibrosis and Cirrhosis

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