Inhibition of Mahkota Dewa ( Phaleria macrocarpa ) bioactive fraction on proliferation of human retinoblastoma tumor cells Y-79 through suppression of mRNA level of cyclin E

Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques

“…The fractionated extract of fruit flesh (endocarp) of P. macrocarpa designated as DLBS1425 showed inhibitory activity toward human retinoblastoma Y-79 cell line proliferation ( Trilaksana et al, 2017 ). DLBS1425 lowered the number of Y-79 human retinoblastoma tumor cells corresponding to the dosage levels.…”

“…DLBS1425 was considered to inhibit the gene transcription of cyclin E human retinoblastoma tumor cell Y-79 at the level of messenger RNA (mRNA) without going through the p21 gene regulation line. It could be a potential scaffold for developing anti-cancer drug therapy ( Trilaksana et al, 2017 ).…”

Effect of Feed Flowrates on the Physical Properties and Antioxidant of Mahkota Dewa (Phaleria Macrocarpa) Encapsulated Powder

“…The plant is quite popular among South East Asian peoples and is traditionally used in local folk medicine as complementary alternative medicine for several diseases such as cancer, hypertension, and diabetes mellitus. The major parts of the plant namely the stem, leaves, egg shell of the seeds, and fruits are mostly enriched in https://doi.org/10.31436/iiumej.v23i2.1713 bioactive compounds such as alkaloids, flavanoids, mangiferin, polyphenols, and saponins [2,3]. In particular, Mahkota Dewa fruit has been related to antioxidant activity and hence, the use of this fruit can be suggested as a strategy to control hyperglycemia problems in diabetic patients.…”