Inhibition of malate and acetoacetate synthesis by their fluoro analogs

Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate

“…These substances presumably compete with the malate for the binding sites of the enzyme. Gal (1958) found very little inhibition of the malic enzyme by fluorocitrate, but the highest concentration tried by him was 0-066 mm. He found a 60 % inhibition by 0 7 mm-fluoromalate.…”