Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E‐box motif

Taniguchi, Masashi; Fujiwara, Kyoko; Nakai, Yuji; Ozaki, Toshinori; Koshikawa, Nobuko; Kojima, Toshio; Kataba, Motoaki; Oguni, Asako; Matsuda, Hiroyuki; Yoshida, Yukihiro; Tokuhashi, Yasuaki; Fukuda, Noboru; Ueno, Takayoshi; Soma, Masayoshi; Nagase, Hiroki

doi:10.1016/j.fob.2014.03.004

Cited by 31 publications

(22 citation statements)

References 25 publications

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“…MALAT1 was one of the first lncRNAs to be demonstrated its close implication in cancer, and a series of studies has established the importance of MALAT1 as a marker of cancers ( [95], multiple myeloma [73,96,97], neuroblastoma [37,38], osteosarcoma [42,98], ovarian cancer [99], pituitary adenoma [100], prostate cancer [101][102][103], and renal cell carcinoma [50,104].…”

Section: Malat1 and Cancermentioning

confidence: 99%

MALAT1 long non-coding RNA in cancer

Yoshimoto

Mayeda

Yoshida

et al. 2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

196

148

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Section: Malat1 and Cancermentioning

confidence: 99%

MALAT1 long non-coding RNA in cancer

Yoshimoto

Mayeda

Yoshida

et al. 2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

196

148

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“…Taniguchi M et al pointed out that Myc-6 may serve as a tumor suppressor in human OS cells partly by specifically down-regulating MALAT1, implying the potential role of MALAT1in OS development [53]. Subsequently, Dong Y et al reported that MALAT1 played an oncogenic role to promote cell growth in OS, probably by activating PI3K/AKT signaling pathway [54].…”

Section: Lncrnas In Cell Growth and Proliferationmentioning

confidence: 99%

Long non-coding RNAs in osteosarcoma

et al. 2017

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Long non-coding RNAs (lncRNAs) with more than 200 nuleotides, have been explored to participate in various cancer types including osteosarcoma (OS), which is the most common kind of primary bone tumors with high morbidity in infants and adolescents. These oncogenic or tumor suppressive lncRNAs regulate OS pathogenesis, such as cell growth, proliferation, invasion, migration, metastasis and cell apoptosis, serve as independent prognostic biomarkers or play a significant role in multidrug resistance (MDR) in OS cells. In this review, we attempt to dissect the participation of lncRNAs in pathogenesis of OS and their potential clinical values, and also provide an outlook for viable biomarkers and therapeutic targets in OS.

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“…MALAT1 was also upregulated in the metastatic tissue of bladder cancer and contributed to bladder cancer cell migration [17]. Furthermore, Myc-6, a tumorsuppressive regulator, could repress tumor growth via downregulation of MALAT1 [18]. Recent evidence supported the hypothesis that MALAT1 could be a regulator of posttranscriptional RNA processing or modification in cancer [19].…”

Section: Introductionmentioning

confidence: 99%

MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway

Dong¹,

Liang²,

Yuan³

et al. 2014

Tumor Biol.

280

222

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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), one of the first found cancer-associated long noncoding RNAs (lncRNAs), involves in the development and progression of many types of tumors. An aberrant expression of MALAT1 was observed in hepatocellular carcinoma, cervical cancer, breast cancer, ovarian cancer, and colorectal cancer. However, the exact effects and molecular mechanisms of MALAT1 in osteosarcoma progression are still unknown up to now. Here, we investigated the role of MALAT1 in human osteosarcoma cell lines and clinical tumor samples in order to determine the function of this molecule. In our research, the MALAT1 messenger RNA (mRNA) was highly expressed in human osteosarcoma tissues, and its expression level was closely correlated with pulmonary metastasis. Then, we employed lentivirus-mediated knockdown of MALAT1 in U-2 OS and SaO2 to determine the role of MALAT1 in osteosarcoma cell lines. Lentivirus-mediated MALAT1 small interfering RNA (siRNA) could efficiently downregulated the expression level of MALAT1 in osteosarcoma cell lines. Knockdown of MALAT1 inhibited the proliferation and invasion of human osteosarcoma cell and suppressed its metastasis in vitro and vivo. At the same time, the proliferating cell nuclear antigen (PCNA), matrix metallopeptidase 9 (MMP-9), phosphorylated PI3Kp85α, and Akt expressions were significantly inhibited in MALAT1-deleted cells. These findings indicated that MALAT1 might suppress the tumor growth and metastasis via PI3K/AKT signaling pathway. Taken together, our data indicated that MALAT1 might be an oncogenic lncRNA that promoted proliferation and metastasis of osteosarcoma and could be regarded as a therapeutic target in human osteosarcoma.

show abstract

Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E‐box motif

Cited by 31 publications

References 25 publications

MALAT1 long non-coding RNA in cancer

MALAT1 long non-coding RNA in cancer

Long non-coding RNAs in osteosarcoma

MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway

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