Inhibition of matrix metalloproteinases related to metastasis by diosgenyl and pennogenyl saponins

Anti-cancer Effects of CME-1, a Novel Polysaccharide, Purified from the Mycelia of Cordyceps sinensis against B16-F10 Melanoma Cells

“…These results imply that the potential ability of CME-1 in reducing melanoma cell migration may be through the induction of cell differentiation. These findings are in accordance with the results of Man et al, [22] as they found that saponin Paris H suppressed cancer cells migration through down-regulation of MMP-1, -3 and -14 in B16F10 melanoma cells without causing cell toxicity.…”

Comparative study on hemostatic, cytotoxic and hemolytic activities of different species of Paris L.

“…While Rhizoma Paridis is one of the major components of the well-known prepared Chinese medicines like Yunnan Baiyao Powder which is famous for the hemostatic activity and Jidesheng Sheyao Tablet which is used to treat of snake bite. In our laboratory, we have reported many papers about the chemical components and anti-tumor activity of Rhizoma Paridis (Yan et al, 2009;Man et al, 2009aMan et al, , 2009bMan et al, , 2010Man et al, , 2011aMan et al, , 2011b. Now the endangered status is more and more severe with the increasing application of Rhizoma Paridis.…”

Metastatic Inhibitory and Radical Scavenging Efficacies of Saponins Extracted from the Brittle Star (Ophiocoma erinaceus)

“…In another study, Man et al (2011) examined antitumor activity of diosgenyl and pennogenylsaponins extracted from Rhizoma Paradis. They found that these saponin substances possess anti aggressive efficacy against B16F10 melanoma cells through suppression of MMP-2 and MMP-9 activity in translational level.…”