Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle

Miletić, Maja; Vuković, Dragana; Zivanovic, Irena; Dakić, Ivana; Soldatović, Ivan; Maletic, Dejan; Lazović, Saša; Malović, Gordana; Petrović, Zoran Lj.; Puаč, Nevena

doi:10.2478/s11534-014-0437-z

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…Total inhibition of biofilm formation (a 5 log decrease in CFU/ml) was achieved either by 2-min treatment with NTP produced at 0.9 W or only a 1-min exposure to NTP formed at 1.6 W. Different power regimes for NTP formation were also used in Modic et al (2017). The NTP used in this study achieved total inhibition (6.5 log decrease) of biofilm formation on coupons after 2 min at both working powers (8 and 34.5 W), similarly to Miletić et al (2014). Cotter et al (2011) studied the effect of NTP on S. aureus biofilms formed on coverslips.…”

Section: Biofilmmentioning

confidence: 83%

“…The occurrence of biofilm-related S. aureus infection is very common, so it is not surprising that NTP is primarily used to eradicate such contamination or to prevent surface biofilm formation. Miletić et al (2014) focused on the treatment of cell suspension before the biofilm formation in polystyrene microtiter plates using NTP discharge working at two power settings. Total inhibition of biofilm formation (a 5 log decrease in CFU/ml) was achieved either by 2-min treatment with NTP produced at 0.9 W or only a 1-min exposure to NTP formed at 1.6 W. Different power regimes for NTP formation were also used in Modic et al (2017) .…”

Section: Non-thermal Plasma Treatment Of Eskape Pathogensmentioning

confidence: 99%

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Non-thermal Plasma Treatment of ESKAPE Pathogens: A Review

et al. 2021

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The acronym ESKAPE refers to a group of bacteria consisting of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. They are important in human medicine as pathogens that show increasing resistance to commonly used antibiotics; thus, the search for new effective bactericidal agents is still topical. One of the possible alternatives is the use of non-thermal plasma (NTP), a partially ionized gas with the energy stored particularly in the free electrons, which has antimicrobial and anti-biofilm effects. Its mechanism of action includes the formation of pores in the bacterial membranes; therefore, resistance toward it is not developed. This paper focuses on the current overview of literature describing the use of NTP as a new promising tool against ESKAPE bacteria, both in planktonic and biofilm forms. Thus, it points to the fact that NTP treatment can be used for the decontamination of different types of liquids, medical materials, and devices or even surfaces used in various industries. In summary, the use of diverse experimental setups leads to very different efficiencies in inactivation. However, Gram-positive bacteria appear less susceptible compared to Gram-negative ones, in general.

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Section: Biofilmmentioning

confidence: 83%

Section: Non-thermal Plasma Treatment Of Eskape Pathogensmentioning

confidence: 99%

Non-thermal Plasma Treatment of ESKAPE Pathogens: A Review

et al. 2021

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“…Sharma et al [ 35 ] analyzed the influence of feeding gas flow rate in bacterial inactivation using Argon (Ar) and Helium (He) gas, and they noticed a decrease in the pathogen inactivation with the increased Ar gas flow; however, the observation was upturned while using He as the feeding gas [ 35 ]. The power and frequency have also a significant effect on pathogen inactivation; the inactivation efficiency of LTP increases with the increase in the input frequency and (or) power [ 36 , 37 ]. Studies with S. aureus show the bacterial inactivation efficiency of LTP by varying voltage.…”

Section: Introduction Low-temperature Plasma On Medicinementioning

confidence: 99%

Low-Temperature Plasma Techniques in Biomedical Applications and Therapeutics: An Overview

Karthik,

Sarngadharan,

Thomas

2023

IJMS

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Plasma, the fourth fundamental state of matter, comprises charged species and electrons, and it is a fascinating medium that is spread over the entire visible universe. In addition to that, plasma can be generated artificially under appropriate laboratory techniques. Artificially generated thermal or hot plasma has applications in heavy and electronic industries; however, the non-thermal (cold atmospheric or low temperature) plasma finds its applications mainly in biomedicals and therapeutics. One of the important characteristics of LTP is that the constituent particles in the plasma stream can often maintain an overall temperature of nearly room temperature, even though the thermal parameters of the free electrons go up to 1 to 10 keV. The presence of reactive chemical species at ambient temperature and atmospheric pressure makes LTP a bio-tolerant tool in biomedical applications with many advantages over conventional techniques. This review presents some of the important biomedical applications of cold-atmospheric plasma (CAP) or low-temperature plasma (LTP) in modern medicine, showcasing its effect in antimicrobial therapy, cancer treatment, drug/gene delivery, tissue engineering, implant modifications, interaction with biomolecules, etc., and overviews some present challenges in the field of plasma medicine.

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“…In addition, these bacteria tend to 51 form biofilms where bacteria are well protected from 52 the outside agents. It has been shown that plasmas may sterilize even the biofilms as well as planktonic samples 54 [22].…”

Section: Introductionmentioning

confidence: 99%

Helium atmospheric pressure plasma jet parameters and their influence on bacteria deactivation in a medium

et al. 2022

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Atmospheric pressure plasmas are becoming relevant in local microbial deactivation and other combined effects of plasmas on living organisms. For this reason, our research was focussed on optimisation of atmospheric pressure plasma jet (APPJ) parameters to complete the deactivation of different bacteria strains in a medium. Different helium APPJ treatments with different discharge parameters were used, such as input voltages and gas flows. To better understand plasma properties behind complete bacteria deactivation at optimised discharge parameters, optical and electrical plasma jet diagnostics were performed, including electrical characterisation of the plasma source, optical emission spectroscopy of the plasma plume and intensified charged coupled device imaging of the discharge behaviour for every set of plasma parameters. Then, the resulting plasma liquid chemistry was assessed to establish the connections between reactive species generated in the gaseous and liquid phases. The most efficient deactivation was found for higher discharge powers and gas flow rates, and that was linked to higher densities of reactive oxygen and nitrogen species, especially hydrogen peroxide and medium solvated charges.

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Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle

Cited by 8 publications

References 48 publications

Non-thermal Plasma Treatment of ESKAPE Pathogens: A Review

Non-thermal Plasma Treatment of ESKAPE Pathogens: A Review

Low-Temperature Plasma Techniques in Biomedical Applications and Therapeutics: An Overview

Helium atmospheric pressure plasma jet parameters and their influence on bacteria deactivation in a medium

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