Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: A relation with NO-system

Balenovic, Dijana; Benčić, Martina Lovrić; Udovičić, Mario; Šimonji, Karol; Hanževački, Jadranka Šeparović; Barišić, Ivan; Kranjčević, Stjepan; Prkačin, Ingrid; Ćorić, Vedran; Brčić, Luka; Čorić, Marijana; Brčić, Iva; Borović, Suzana; Radic, Bozo; Drmic, Domagoj; Vrčić, Hrvoje; Seiwerth, Sven; Sikirić, Predrag

doi:10.1016/j.regpep.2009.05.008

Cited by 56 publications

(82 citation statements)

References 14 publications

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“…of collagen degradation (mainly Pro-Glu-Pro, Glu-Pro and ProGlu) [34][35][36]; thymohexin (Arg-α-Asp-Lys-Val-Tyr-Arg) [1,8,37], honluten (H-Glu-Asp-Gly-OH), known as T-34 [20,21], vesugen (H-Lys-Glu-Asp-OH), known as T-38 [20].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the modern knowledge, gastroprotective effects of the short peptides are mediated by their antioxidant and antiinflammatory properties [1,5,8,10,16,23,32,37], regulatory influence on acid/base secretion [9,24,25,35], motility [38,39], activity of the gastrointestinal enzymes [9,13,16,20,21], production of prostaglandins and nitric oxide as well as the interaction with the neuroendocrine system [1,12,27,31,33,34]. For example, it is known that dipeptide L-carnosine, that for about two decades is used in Japan as antiulcer remedy, exerts its gastroprotective effect through the stimulation of protective mucous production and increases the activity of antioxidant defense enzymes and heat shock proteins expression in stomach, dose dependently preventing gastric ulceration [26].…”

Section: Discussionmentioning

confidence: 99%

Section: Other Oligopeptides With Gastroprotective Propertiesmentioning

confidence: 92%

“…The protective effect of BPC 157 on the model of acetic ulceration coincided with famotidine, but the effective dose of famotidine (40mg/kg) is 50-fold higher compared to BPC 157 (800 ng/kg). At the same time the effect of BPC 157 caused more significant formation of the granulation tissue in the zone of ulcer defect in contrast to famotidine [31][32][33][34].BPC 157 was reported to exert a regulatory influence on the gastric mucosa through the central nervous system and to regulate the number of G and D cells of the stomach [33]. The other mechanisms of the cytoprotective effect of BPC-157 the authors link to the stimulation of the expression of the early growth gene (EGR-1) and its repressor, binding nervous growth factor 1-А [10,49].…”

mentioning

confidence: 95%

“…It was also established that BPC 157 maintains the natural homeostasis of GABA and GABA-ergic transmission [31,32]. The interaction of BPC157 with dopamine [31,32], nitric oxide system [31,34] as well as prostaglandins production was shown [31].Tripeptide vesugen, known as T-38, administered in dose of 20 ng/ml to irradiated animals, was reported to enhance proliferative processes in the tissue of the intestine, thymus and spleen [20]. The authors related this effect to the influence of T-38 on blood vessels that resulted in the improvement of the tissue trophics and stimulation of cell proliferation [20].…”

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Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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IntroductionPeptic ulcer disease and its complications still remain a hot issue in modern gastroenterology and one of the constantly important targets for pharmacologic research [1][2][3]. It is commonly acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs), being the most commonly prescribed group of drugs worldwide for the management of pain and inflammation, play an important role in provoking gastrointestinal tract ulceration, bleeding and perforation [1,4,5]. This mediates the necessity of the effective gastroprotective measures in patients, who are at risk of gastric ulceration, in particular chronic NSAIDs users. Nowadays for this purpose proton pump inhibitors and H 2 -antagonists are commonly used, but due to side effects of these drugs the search for new compounds with gastroprotective properties, suitable for longterm use, remains actual [1,2]. Contemporary literature gives accumulating evidence that a number of oligopeptides play an important role in the regulation of the function of gastrointestinal tract and their synthetic analogues were reported to be effective in the prevention and treatment of gastric ulceration [1,[5][6][7][8][9][10][11][12].That is why the purpose of this review was to summarize the current data on the oligopeptides with documented gastroprotective properties and their possible mechanisms of action. DiscussionDue to the modern outlook, regulatory peptides are considered to be phylogenetically the oldest form of bioregulation [13][14][15][16][17][18][19][20][21]. Thus, the mechanisms of peptidergic regulation of homeostasis open huge perspectives for the creation of the essentially new methods for the prevention and treatment of different diseases [13][14][15][16]. Interestingly, deep studies of the mechanisms of action of regulatory peptides showed that in many cases life-sustaining processes are regulated not by the total peptide molecules but their short-chained derivatives -oligopeptides that are produced in the course of limited proteolysis from proteins-precursors (cytokines, thymic peptides, immunoglobulins) [13,14,18,20,21].The term "oligopeptide" refers to proteins, composed of not more than 20 amino acid residues [22]. For example, it was shown that the inhibition of pancreatic juice secretion by 28-amino acidscontaining hormone ghrelin is realized by its biologically active part -pentapeptide with the sequence of amino acids Gly-Ser-Ser (n-octanoyl)-Phe [23].The advantages of the short peptides above their long-chain derivatives are high biological activity, that often many fold exceeds the activity of the peptide-precursor, high tissue specificity, lack of species specificity and lack of immunogenicity [13,14,[15][16][17][18]20,21]. It was established that low-weighing oligopeptides realize their effect on the cellular, chromosomal, genomic and molecular levels [13][14][15][16][17][18][19][20][21]. The interaction with DNA was proposed to be the key moment of the realization of the biological effect of the short peptides [17][18][19]21]. This concept is s...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Other Oligopeptides With Gastroprotective Propertiesmentioning

confidence: 92%

mentioning

confidence: 95%

mentioning

confidence: 99%

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Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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Stable Gastric Pentadecapeptide BPC 157 and NO-System

Sikirić¹,

Drmic²,

Blagaić³

et al. 2023

Advances in Biochemistry in Health and Disease

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BPC 157 antagonized the general anaesthetic potency of thiopental and reduced prolongation of anaesthesia induced by l-NAME/thiopental combination

et al. 2015

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We hypothesized the general anesthetic thiopental effect depending on NO‐related mechanisms, consequently counteracted by stable gastric pentadecapeptide BPC 157. (i) To determine the general anesthetic effect of thiopental and possible counteraction depending on BPC 157 administration, all rats received intraperitoneally thiopental (20, 30, 40 mg/kg) while medication (BPC 157 (10 μg/kg, 10 ng/kg, 10 pg/kg) was given intraperitoneally at 5 min before thiopental. (ii) To determine NO‐related mechanisms, all rats received intraperitoneally thiopental 40 mg/kg while BPC 157 (10 μg/kg), L‐NAME (10 mg/kg), L‐arginine (30 mg/kg) were applied alone and/or combined. BPC 157 was given at 25 min before thiopental while L‐NAME, L‐arginine, alone and/or combined, were applied at 20 min before thiopental. (i) BPC 157 (10 ng/kg and 10 μg/kg), caused significant antagonism of general anesthesia produced by thiopental with a parallel shift of the dose‐response curve to the right. (ii) L‐NAME. Thiopental‐induced anesthesia duration was tripled. L‐arginine. Active only given with L‐NAME or BPC 157: habitual thiopental anesthesia time not influenced; potentiating effects of L‐NAME lessened, not abolished; shortening effect of BPC 157: abolished. BPC 157 and L‐NAME. Potentiating effects of L‐NAME was abolished. L‐NAME and L‐arginine and BPC 157. L‐NAME+L‐arginine+BPC 157 rats exhibited values close to those in BPC 157 rats. Thiopental general anaesthesia is simultaneously manipulated in both ways with NO‐system activity modulation, L‐NAME (prolongation) and BPC 157 (shortening/counteraction). BPC 157 and L‐arginine might serve two NO‐system pathways, more or less active, alternatively activated. Grant Funding Source: Supported by Grant 108‐ 1083570‐3635, Croatia

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Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: A relation with NO-system

Cited by 56 publications

References 14 publications

Gastroprotective Oligopeptides

Gastroprotective Oligopeptides

Stable Gastric Pentadecapeptide BPC 157 and NO-System

BPC 157 antagonized the general anaesthetic potency of thiopental and reduced prolongation of anaesthesia induced by l-NAME/thiopental combination

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