Inhibition of Mettl3 ameliorates osteoblastic senescence by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent mechanisms

Liu, Xiao-Wei; Xu, Hao-Wei; Yi, Yu-Yang; Zhang, Shu-Bao; Chang, Sheng-Jie; Pan, Wei; Wang, Shan-Jin

doi:10.1016/j.bbadis.2024.167273

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

2024

DOI: 10.1016/j.bbadis.2024.167273

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Inhibition of Mettl3 ameliorates osteoblastic senescence by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent mechanisms

Xiao-Wei Liu,

Hao-Wei Xu,

Yu-Yang Yi

et al.

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RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells

Zhang,

Zhu,

Zhang

et al. 2024

Food Science & Nutrition

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Resveratrol, a natural compound found in various plants, is known for its anti‐inflammatory, antioxidant, and senescence‐delaying properties. RNA N6‐methyladenosine (m6A) methylation plays a crucial role in oxidative stress and premature cellular senescence processes and is closely associated with age‐related disorders. However, the anti‐premature senescence via RNA m6A methylation mechanism of resveratrol is still not fully understood. In this study, based on premature senescence model of human embryonic lung fibroblasts (HEFs) induced by hydrogen peroxide (H2O2), a widely accepted model of premature senescence caused by oxidative stress, we explored the anti‐aging regulatory effects of resveratrol at the RNA m6A methylation level. Our data suggested that resveratrol significantly delayed premature senescence by increasing cell viability, reducing SA‐β‐gal blue staining rate, ROS levels, and senescence‐associated secretory phenotypes (SASP) expression in HEFs. Meanwhile, resveratrol increased the whole RNA methyltransferases activity and the overall m6A level during senescence. Furthermore, three genes CCND2, E2F1, and GADD45B have been identified as the main ones regulating premature by resveratrol. Specifically, it decreased E2F1, GADD45B RNA m6A methylation level, and increased CCND2 level in premature cells. Our study provided new clues for exploring the mechanism and application of resveratrol in the field of premature aging.

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RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells

Zhang,

Zhu,

Zhang

et al. 2024

Food Science & Nutrition

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Inhibition of Mettl3 ameliorates osteoblastic senescence by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent mechanisms

Cited by 1 publication

References 58 publications

RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells

RNA m6A methylation regulatory mechanism of resveratrol in premature senescence cells

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