2021
DOI: 10.1101/2021.03.24.436896
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Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury

Abstract: Background & Aims: While altered host-microbe interactions are implicated in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH), specific contributions of microbially derived metabolites remain obscure. We investigated the impact of altered bile acid (BA) populations on intestinal and hepatic phenotypes in a rodent model of NAFLD/NASH. Methods: Wistar rats fed a choline-deficient high-fat diet (CDAHFD) were assessed for altered intestinal permeability after dietary intervention. C… Show more

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Cited by 2 publications
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“…A recent preprint corroborated our findings that conjugated bile acids are protective against cytotoxic compounds ( 56 ). Unconjugated bile acids increased the permeability of Caco-2 monolayers whereas conjugated bile acids prevented this disruption of membrane integrity by forming micelles around unconjugated bile acids.…”
Section: Discussionsupporting
confidence: 85%
“…A recent preprint corroborated our findings that conjugated bile acids are protective against cytotoxic compounds ( 56 ). Unconjugated bile acids increased the permeability of Caco-2 monolayers whereas conjugated bile acids prevented this disruption of membrane integrity by forming micelles around unconjugated bile acids.…”
Section: Discussionsupporting
confidence: 85%