Inhibition of microflora associated with oral malignancy

Nagy, Katalin; Szöke, I.; Sonkodi, I; Nagy, Elisabeth; Mari, Amir; Szolnoky, Győző; Newman, H. N.

doi:10.1016/s1368-8375(99)00046-9

Cited by 21 publications

(25 citation statements)

References 11 publications

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“…In earlier studies of the microbial ecology of saliva, culture based methods were primarily used and the majority of microbial community remained hidden 41–47 . However, advances in DNA sequencing have made it possible to undertake in-depth analyses of microbes that are not amenable to culture using high-throughput sequencing of the microbial 16 S rRNA gene 48, 49 .…”

Section: Discussionmentioning

confidence: 99%

The salivary microbiome as an indicator of carcinogenesis in patients with oropharyngeal squamous cell carcinoma: A pilot study

Wolf

Moissl-Eichinger

Perras

et al. 2017

Sci Rep

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This study aimed to undertake an initial, comparative analysis of the oral salivary microbiome of patients with oral and oropharyngeal squamous cell carcinoma versus healthy controls. This project, conceived as a pilot study, included 11 patients (1 female, 10 male, mean age 61.6 yrs., SD = 8.2 yrs.) and 11 healthy controls (1 female, 10 male, mean age 46.7 yrs., SD = 15.1 yrs.). Samples of saliva were analysed by high-throughput sequencing of the 16S rRNA gene using the MiSeq platform. Sequence data revealed microbial changes that may mirror disease progression and reflect clinical preconditions such as age, alcohol consumption, tumour size, lymph node status, smoking habit, and tumour HPV-positivity. Consequently, mapping microbial changes in patients with oral and oropharyngeal squamous cell carcinomas might improve our understanding of the pathobiology of the disease, and help in the design of novel diagnostic and treatment strategies.

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Section: Discussionmentioning

confidence: 99%

The salivary microbiome as an indicator of carcinogenesis in patients with oropharyngeal squamous cell carcinoma: A pilot study

Wolf

Moissl-Eichinger

Perras

et al. 2017

Sci Rep

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“…Oncologic therapy, such as irradiation or chemotherapy, further impairs the defense mechanism of the oral mucosa with the resultant proliferation of mucosal biofilms with subsequent overgrowth, particulary of yeast and anaerobic bacteria (11).…”

Section: Mutans S Sobrinus S Downei S Rattus S Cricetus Smentioning

confidence: 99%

Prevalence of Oral Microbes in the Saliva of Oncological Patients

Kang

Kim

et al. 2009

J Bacteriol Virol

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This study examined the prevalence of oral microbes in the saliva of oncological patients and healthy subjects. PCR was used to assess the frequency of oral microbes including 3 cariogenic bacteria, 5 periodontopathic bacteria and 4 Candida species in the saliva of 104 oncological patients and 52 healthy subjects. Among these microorganims, Streptococcus mutans, Fusobacterium nucleatum and Candida albicans were most frequently detected in both groups. There were no significant differences in the prevalence of cariogenic bacteria between the patient and healthy groups, whereas significant differences in the frequency of Porphyromonas gingivalis and Tannerella forsythia were observed between the two groups (p < 0.05). The prevalence of all five periodontopathogens was higher in the healthy group than in the patient group. The prevalence of C. albicans in patients was significantly higher than that of healthy group (p < 0.05). In conclusion, there were significant differences in the prevalence of P. gingivalis, T. forsythia and C. albicans between the oncological patient group and healthy group.

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“…Any loss in integrity of oral epithelial barrier exposes the underlying tissues to various aerobic and anaerobic microflora of oral cavity [33]. Hence, the local and systemic polymicrobial mucosal infections may be a result of invading potentially pathogenic microorganism of extra-oral origin or a shift within the normal commensal microflora taken up by opportunistic microflora in immuno-compromised individuals [33]. …”

Section: Introductionmentioning

confidence: 99%

Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma

et al. 2012

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BackgroundBacterial infections have been linked to malignancies due to their ability to induce chronic inflammation. We investigated the association of oral bacteria in oral squamous cell carcinoma (OSCC/tumor) tissues and compared with adjacent non-tumor mucosa sampled 5 cm distant from the same patient (n = 10). By using culture-independent 16S rRNA approaches, denaturing gradient gel electrophoresis (DGGE) and cloning and sequencing, we assessed the total bacterial diversity in these clinical samples.ResultsDGGE fingerprints showed variations in the band intensity profiles within non-tumor and tumor tissues of the same patient and among the two groups. The clonal analysis indicated that from a total of 1200 sequences characterized, 80 bacterial species/phylotypes were detected representing six phyla, Firmicutes, Bacteroidetes, Proteobacteria, Fusobacteria, Actinobacteria and uncultivated TM7 in non-tumor and tumor libraries. In combined library, 12 classes, 16 order, 26 families and 40 genera were observed. Bacterial species, Streptococcus sp. oral taxon 058, Peptostreptococcus stomatis, Streptococcus salivarius, Streptococcus gordonii, Gemella haemolysans, Gemella morbillorum, Johnsonella ignava and Streptococcus parasanguinis I were highly associated with tumor site where as Granulicatella adiacens was prevalent at non-tumor site. Streptococcus intermedius was present in 70% of both non-tumor and tumor sites.ConclusionsThe underlying changes in the bacterial diversity in the oral mucosal tissues from non-tumor and tumor sites of OSCC subjects indicated a shift in bacterial colonization. These most prevalent or unique bacterial species/phylotypes present in tumor tissues may be associated with OSCC and needs to be further investigated with a larger sample size.

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Inhibition of microflora associated with oral malignancy

Cited by 21 publications

References 11 publications

The salivary microbiome as an indicator of carcinogenesis in patients with oropharyngeal squamous cell carcinoma: A pilot study

The salivary microbiome as an indicator of carcinogenesis in patients with oropharyngeal squamous cell carcinoma: A pilot study

Prevalence of Oral Microbes in the Saliva of Oncological Patients

Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma

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