Inhibition of mitogen-stimulated T lymphocyte proliferation by calcitonin gene-related peptide

Umeda, Yohtaro; Takamiya, Mari; Yoshizaki, H; Arisawa, Mikio

doi:10.1016/0006-291x(88)90674-2

Cited by 125 publications

(68 citation statements)

References 22 publications

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“…CGRP has come to be Included among ihc pcptides with immunomodulatory potential. These pcptides are able to modulate many immune activities that may operate in adjuvantinduced inflammation, such as the proliferation ofT cells [7][8][9][10][11][12][13]. activation of macrophages and T colls [21 24].…”

Section: Discussionmentioning

confidence: 99%

“…and others [3-61-These peptides have been shown to modulate numerous immune functions both In vitro and in riro. including the proliferative [7][8][9][10][11][12][13] and migratory [I4-I6J properties of lymphocytes, antigen production [12,13,17], cytokine production [18][19][20]. and macrophage activation [18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

“…SP enhances lymphocyte prnliferation [7.12]. whereas VIP, SOM and CGRP inhibit lymphocyte proliferation and IL-2 production [8][9][10][11][12][13]. SP stimulates cytokine production and macrophage activation [18][19][20][21][22], whereas VIP and CGRP suppress macrophage activation [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Neonatal capsaicin pretreatment suppresses intramedullary inflammation in adjuvant-induced spondylitis

Imai

Hukuda

Maeda

1994

Clinical and Experimental Immunology

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SUMMARYIn order lo investigate the proposed involvement of neuropeptides in musculoskeletal inflammation we pretreated rats, in an adjuvant spondylitis model, wilh capsaicin, a neurotoxin. Immunohisiochemistry showed that administration of capsaicin to newborn rats depicted irreversibly the neuropeptide. suhstance P. Eliminalion of capsaicin-sensitive fibres by the neonatul injection of capsaicin did not suppress the peridiscitis of rats in which adjuvant spondylilis was induced at 7 weeks of age. However, elimination of capsaicin-sensitive fibres did suppress the inflammation usually seen in the bone marrow. We speculate that this iniramedullary inflammation is normally induced or sustained by capsaicin-sensitive fibres.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neonatal capsaicin pretreatment suppresses intramedullary inflammation in adjuvant-induced spondylitis

Imai

Hukuda

Maeda

1994

Clinical and Experimental Immunology

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“…In addition, the calcitonin gene-related peptide (CGRP), a neuropeptide, is involved in cutaneous inflammation following DYB irradiation (60). CGRP causes potent vasodilation (61) and also several immunomodulatory effects (62)(63)(64)(65)(66)(67)(68). CGRP inhibits antigen presentation by LC, contact hypersensitivity (CHS) and delayed-type hypersensitivity (DTH) (69)(70)(71), proliferation of T lymphocytes (62), activation of NK cells (66), and functions of macrophages (70)(71)(72)(73).…”

Section: Damageddna Urocanicacid and Cutaneous Nervous System Are Rmentioning

confidence: 99%

“…CGRP causes potent vasodilation (61) and also several immunomodulatory effects (62)(63)(64)(65)(66)(67)(68). CGRP inhibits antigen presentation by LC, contact hypersensitivity (CHS) and delayed-type hypersensitivity (DTH) (69)(70)(71), proliferation of T lymphocytes (62), activation of NK cells (66), and functions of macrophages (70)(71)(72)(73). DYBinduced immunosuppression is prevented in mice by a complete inhibition sensory nerve fiber function by injecting capsaicin, a neurotoxin into skin (74).…”

Section: Damageddna Urocanicacid and Cutaneous Nervous System Are Rmentioning

confidence: 99%

Dissociation of Innate and Adaptive Immunity by UVB Irradiation

Kasahara

Wago

2002

Int J Immunopathol Pharmacol

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Increasing ultraviolet-B irradiation (UVB) resulting from diminution of stratospheric ozone is becoming a serious international problem. UVB irradiation exerts not only carcinogenic effects on animals but also causes them to become vulnerable to infections by modulating their immune responses. UVB irradiation suppresses innate immune functions of cells such as macrophages, neutrophiIs, Langerhans cells, dendritic cells, and the serum component, complement. UVB irradiation also causes changes in cytokine profiles, represented by the induction of a paradigm switch involving Thl/Th2 phenotypes. According to earlier studies, Thl responses are suppressed, whereas Th2 activities are augmented by UVB irradiation. These immune modulations are caused by several pathways via cytokines and neuropeptides, and eventually may lead to increasing incidences of infection, allergy, and cancer. We have reviewed reports concerning UVB-irradiation induced immune modulation from the viewpoint of risks for human diseases and, in addition, for ecosystems and immunity of lower animals.

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Peptide and Protein Hormones

König

2000

Ullmann's Encyclopedia of Industrial Chemistry

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Inhibition of mitogen-stimulated T lymphocyte proliferation by calcitonin gene-related peptide

Cited by 125 publications

References 22 publications

Neonatal capsaicin pretreatment suppresses intramedullary inflammation in adjuvant-induced spondylitis

Neonatal capsaicin pretreatment suppresses intramedullary inflammation in adjuvant-induced spondylitis

Dissociation of Innate and Adaptive Immunity by UVB Irradiation

Peptide and Protein Hormones

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