Inhibition of mouse colon cancer growth following immunotherapy with a fraction of hydatid cyst fluid

Rostamirad, Shahla; Daneshpour, Shima; Mofid, Mohammad Reza; Andalib, Alireza; Eskandariyan, Abbasali; Mousavi, Somayeh; Darani, Hossein Yousofi

doi:10.1016/j.exppara.2023.108501

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Animal models are essential for evaluating the efficacy of potential cancer therapies. Among other animals, mice have been used to investigate the impact of HCF or its antigens on tumor growth and metastasis [25]. The fluid and antigens have been administered intraperitoneally or subcutaneously to simulate a clinical setting.…”

Section: Animal Models: Effects On Tumor Growthmentioning

confidence: 99%

Investigating the Inhibitory Effects of Hydatid Cyst Fluid and its Antigens on Cancer Progression: A Review

Shojaeian,

Barati,

Motavallihaghi

2023

Preprint

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Hydatid cyst fluid is a complex biological substance consisting primarily of water, proteins, lipids, carbohydrates, salts, enzymes, hormones, growth factors, immune modulators, and other bioactive molecules. Antigens, including antigen B (AgB) and antigen 5 family members (Ag5), have been identified in hydatid cyst fluid and have been shown to have the ability to inhibit cancer progression. The exact mechanisms by which these components exert inhibitory effects on cancer progression are not fully understood, but it is believed that they may influence multiple signaling pathways involved in cell proliferation, survival, angiogenesis, and metastasis. In vitro studies have demonstrated that treatment with hydatid cyst fluid or specific antigens can inhibit cell growth, induce apoptosis, and suppress the migration of cancer cells. Animal model studies have also demonstrated significant inhibition of tumor growth, reduction in angiogenesis, and suppression of metastasis. Limited clinical studies have shown promising outcomes, including improved overall survival and reduced recurrence rates among breast cancer patients receiving AgB immunotherapy alongside standard treatment.

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Section: Animal Models: Effects On Tumor Growthmentioning

confidence: 99%

Investigating the Inhibitory Effects of Hydatid Cyst Fluid and its Antigens on Cancer Progression: A Review

Shojaeian,

Barati,

Motavallihaghi

2023

Preprint

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Parasite-enhanced immunotherapy: transforming the “cold” tumors to “hot” battlefields

Xie,

Wang,

Wang

et al. 2024

Cell Commun Signal

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Immunotherapy has emerged as a highly effective treatment for various tumors. However, the variable response rates associated with current immunotherapies often restrict their beneficial impact on a subset of patients. Therefore, more effective treatment approaches that can broaden the scope of therapeutic benefits to a larger patient population are urgently needed. Studies have shown that some parasites and their products, for example, Plasmodium , Toxoplasma , Trypanosoma , and Echinococcus , can effectively transform "cold" tumors into "hot" battlefields and reshape the tumor microenvironment, thereby stimulating innate and adaptive antitumor immune responses. These parasitic infections not only achieve the functional reversal of innate immune cells, such as neutrophils, macrophages, myeloid-derived suppressor cells, regulatory T cells, and dendritic cells, in tumors but also successfully activate CD4 + /CD8 + T cells and even B cells to produce antibodies, ultimately resulting in an antitumor-specific immune response and antibody-dependent cellular cytotoxicity. Animal studies have confirmed these findings. This review discusses the abovementioned content and the challenges faced in the future clinical application of antitumor treatment strategies based on parasitic infections. With the potential of these parasites and their byproducts to function as anticancer agents, we anticipate that further investigations in this field could yield significant advancements in cancer treatment.

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Parasites revive hope for cancer therapy

Eissa,

Salem,

El Skhawy

2024

Eur J Med Res

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Parasites have attained a life-long stigma of being detrimental organisms with deleterious outcomes. Yet, recently, a creditable twist was verified that can dramatically change our perception of those parasites from being a source of misery to millions of people to a useful anti-cancerous tool. Various parasites have shown promise to combat cancer in different experimental models, including colorectal, lung, and breast cancers, among others. Helminths and protozoan parasites, as well as their derivatives such as Echinococcus granulosus protein KI-1, Toxoplasma gondii GRA15II, and Trypanosoma cruzi calreticulin, have demonstrated the ability to inhibit tumor growth, angiogenesis, and metastasis. This article provides an overview of the literature on various cancer types that have shown promising responses to parasite therapy in both in vitro and in vivo animal studies. Parasites have shown anti-neoplastic activity through a variety of mechanisms that collectively contribute to their anti-cancer properties. These include immunomodulation, inhibition of angiogenesis, and molecular mimicry with cancer cells. This review article sheds light on this intriguing emerging field and emphasizes the value of collaborative multidisciplinary research projects with funding agencies and pharmaceutical companies. Thus, these strategies would secure continuous exploration of this new avenue and accelerate the advancement of cancer therapy research. Although experimental studies are heavily conducted by leaps and bounds, further steps are definitely lagging. Upgrading research from the experimental level to the clinical trial would be a wise progression toward efficient exploitation of the anti-neoplastic capabilities of parasites, ultimately saving countless lives.

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Inhibition of mouse colon cancer growth following immunotherapy with a fraction of hydatid cyst fluid

Cited by 3 publications

References 45 publications

Investigating the Inhibitory Effects of Hydatid Cyst Fluid and its Antigens on Cancer Progression: A Review

Investigating the Inhibitory Effects of Hydatid Cyst Fluid and its Antigens on Cancer Progression: A Review

Parasite-enhanced immunotherapy: transforming the “cold” tumors to “hot” battlefields

Parasites revive hope for cancer therapy

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