Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L. (Zygophyllaceae)

Bensalem, Sihem; Soubhye, Jalal; Aldib, Iyas; Bournine, Lamine; Nguyen, Anh Tho; Vanhaeverbeek, Michel; Rousseau, Alexandre Fontaine; Boudjeltia, Karim Zouaoui; Sarakbi, Ahmad; Kauffmann, J.M.; Nève, Jean; Prévost, Martine; Stevigny, Caroline; Maiza-Benabdesselam, Fadila; Bedjou, Fatiha; Antwerpen, Pierre Van; Duez, Pierre

doi:10.1016/j.jep.2014.03.070

Cited by 72 publications

(44 citation statements)

References 55 publications

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“…The seeds and the aerial parts of P. harmala (APP) have been commonly used as traditional folk medicine to treat various ailments, including cough, asthma, rheumatism, hypertension, diabetes, and jaundice in the Xinjiang Uygur and Mongolian Autonomous Regions of China (Chinese Pharmacopoeia Committee, 1998;Zheng et al, 2009). This plant is also a well-known and effective herbal medicine in Turkey, Iran, Algeria, and Morocco (Bensalem et al, 2014;Farouk et al, 2008;Hemmateenejad et al, 2006). Previous phytochemical studies showed that quinazoline alkaloids and flavonoids are the major constituents of APP, and among alkaloids, vasicine (VAS) and deoxyvasicine (DVAS) are the main ones.…”

Section: Introductionmentioning

confidence: 99%

Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (±)-vasicine, deoxyvasicine, and (±)-vasicinone from aerial parts of Peganum harmala L

Liu

Wang

et al. 2015

Phytomedicine

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Section: Introductionmentioning

confidence: 99%

Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (±)-vasicine, deoxyvasicine, and (±)-vasicinone from aerial parts of Peganum harmala L

Liu

Wang

et al. 2015

Phytomedicine

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“…In this study, according to relieve symptoms in patients using P. harmala and tamsulosin, it seems that the vasodilation effect of P. harmala triggered to improve symptoms. Bensalem et al have shown that anti-inflammatory properties of P. harmala are caused by the existence of β-carboline alkaloid that is due to inhibit myeloperoxidase and other factors involved in inflammation (21). …”

Section: Discussionmentioning

confidence: 99%

Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial

2016

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Introduction: Benign prostatic hyperplasia (BPH) is considered as a major cause of lower urinary tract symptoms (LUTS) in older men and its most common sign is nocturia. Objectives: This study aimed to determine the effect of the seeds of Peganum harmala compared with tamsulosin on alleviating urinary symptoms in patients with BPH. Patients and Methods: In this single blind clinical trial study, 90 patients diagnosed with BPH and LUTS, based on international prostate standard survey (IPSS) were divided into three groups. The first group was received oral capsule of P. harmala, the second group was administered tamsulosin with oral P. harmala seed and the third group was received tamsulosin drug and they were evaluated after 4 weeks. Results: The results showed that the difference between mean scores of IPSS was significant after the intervention (P=0.001). Besides, the mean of IPSS in the three groups was significantly different (P=0.001) (the first group 41.9±5.3, the second group 21.0±4.4 ,the third group 16.5±3.7 respectively). However, after the intervention, patients in the second group had the lowest average on most indicators of IPSS but the difference was only significant about urinary frequency, nocturia and intermittency(P<0.05). Conclusion: Application of Peganum harmala seed can be useful in reducing urinary symptoms in patients with BPH.

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“…Specific inhibitors of MPO may inhibit its activity in the tissues, preventing the damage. Among the compounds with anti-MPO activity, there are flavonoids, polyphenols, and melatonin [87,88,89]. …”

Section: Inhibition Of the Vanins–mpo Axismentioning

confidence: 99%

Role of the Vanins–Myeloperoxidase Axis in Colorectal Carcinogenesis

Mariani

Roncucci

2017

IJMS

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The presence of chronic inflammation in the colonic mucosa leads to an increased risk of cancer. Among proteins involved in the regulation of mucosal inflammation and that may contribute both to structural damage of the intestinal mucosa and to intestinal carcinogenesis, there are myeloperoxidase (MPO) and vanins. The infiltration of colonic mucosa by neutrophils may promote carcinogenesis through MPO, a key enzyme contained in the lysosomes of neutrophils that regulates local inflammation and the generation of reactive oxygen species (ROS) and mutagenic species. The human vanin gene family consists of three genes: vanin-1, vanin-2 and vanin-3. All vanin molecules are pantetheinases, that hydrolyze pantetheine into pantothenic acid (vitamin B5), and cysteamine, a sulfhydryl compound. Vanin-1 loss confers an increased resistance to stress and acute intestinal inflammation, while vanin-2 regulates adhesion and transmigration of activated neutrophils. The metabolic product of these enzymes has a prominent role in the inflammation processes by affecting glutathione levels, inducing ulcers through a reduction in mucosal blood flow and oxygenation, decreasing local defense mechanisms, and in carcinogenesis by damaging DNA and regulating pathways involved in cell apoptosis, metabolism and growth, as Nrf2 and HIF-1α.

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Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L. (Zygophyllaceae)

Cited by 72 publications

References 55 publications

Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (±)-vasicine, deoxyvasicine, and (±)-vasicinone from aerial parts of Peganum harmala L

Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (±)-vasicine, deoxyvasicine, and (±)-vasicinone from aerial parts of Peganum harmala L

Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial

Role of the Vanins–Myeloperoxidase Axis in Colorectal Carcinogenesis

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