1998
DOI: 10.1016/s0090-6980(98)00031-8
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Inhibition of Na,K-ATPase by Platelet-Activating Factor in Dog Submandibular Glands

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Cited by 2 publications
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“…Thus, it is reasonable to postulate that PAF induced by RVV may only act locally on a specific PAF receptor in the glomerular and renal medullary interstitial cells ( Asano et al, 1996 ), but also gain access to the renal tubules through glomerular filtration, although the renal tubules do not produce PAF directly ( Pirotzky et al, 1984b ). The mechanism of RVV's action on urinary electrolyte excretion is probably mediated via PAF's regulation of ion channels, where it has been observed to inhibit the membrane Na–K-ATPase in a number of cell types ( Catalan et al, 1994 , Itadani et al, 1998 ). Also PAF inhibits solute reabsorption in the medullary thick ascending limb (mTAL) and collecting ducts via a cGMP-dependent pathway ( Bailly et al, 1992 ).…”
Section: Discussionmentioning
confidence: 99%
“…Thus, it is reasonable to postulate that PAF induced by RVV may only act locally on a specific PAF receptor in the glomerular and renal medullary interstitial cells ( Asano et al, 1996 ), but also gain access to the renal tubules through glomerular filtration, although the renal tubules do not produce PAF directly ( Pirotzky et al, 1984b ). The mechanism of RVV's action on urinary electrolyte excretion is probably mediated via PAF's regulation of ion channels, where it has been observed to inhibit the membrane Na–K-ATPase in a number of cell types ( Catalan et al, 1994 , Itadani et al, 1998 ). Also PAF inhibits solute reabsorption in the medullary thick ascending limb (mTAL) and collecting ducts via a cGMP-dependent pathway ( Bailly et al, 1992 ).…”
Section: Discussionmentioning
confidence: 99%
“…Nystatin treatment increased the sensitivity of the proximal tubules to the inhibitory actions of PAF, suggesting that the lipid may act to reduce basolateral Na ϩ -K ϩ -ATPase pump activity. This conclusion is supported by the observation that ouabain, an Na ϩ -K ϩ -ATPase inhibitor, prevented the inhibitory effect of PAF on nystatin-stimulated proximal tubule QO 2 , as well as several reports that PAF can inhibit membrane Na ϩ -K ϩ -ATPase activity in a number of cell types (4,16). In addition, endogenous PAF was found to contribute to the decrease in renal cortex Na ϩ -K ϩ -ATPase activity after reperfusion of the ischemic rat small intestine, an effect that could be blocked by the PAF receptor antagonist BN-52021 (39).…”
Section: Discussionmentioning
confidence: 54%