2001
DOI: 10.1034/j.1600-065x.2001.1810119.x
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Inhibition of natural killer cell activation signals by killer cell immunoglobulin‐like receptors (CD158)

Abstract: The killer cell immunoglobulin-like receptor (KIR) family includes receptors that bind to HLA class I molecules on target cells and inhibit natural killer (NK)-cell cytotoxicity, and receptors such as KIR3DL7 with no known ligand and function. Inhibitory KIR recruit the tyrosine phosphatase SHP-1 to block signals transduced by any one of a number of activation receptors. Inhibition of overall protein tyrosine phosphorylation by SHP-1 during binding of KIR to MHC class I on target cells is selective, suggesting… Show more

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Cited by 129 publications
(99 citation statements)
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“…However, none of the aforementioned receptors has signaling properties or distributions similar to those reported for KIR2DL4 [11,14,[22][23][24]. By contrast, KIR3DL3, whose ligand and functionality are unknown, shares with KIR2DL4 having a single ITIM and being well conserved in different individuals of several primate species [32][33][34][48][49][50]. Therefore, although the structures of these two receptors are otherwise divergent, this convergent feature makes it worth considering whether they might substitute for some of each other's functions.…”
Section: Discussionmentioning
confidence: 94%
“…However, none of the aforementioned receptors has signaling properties or distributions similar to those reported for KIR2DL4 [11,14,[22][23][24]. By contrast, KIR3DL3, whose ligand and functionality are unknown, shares with KIR2DL4 having a single ITIM and being well conserved in different individuals of several primate species [32][33][34][48][49][50]. Therefore, although the structures of these two receptors are otherwise divergent, this convergent feature makes it worth considering whether they might substitute for some of each other's functions.…”
Section: Discussionmentioning
confidence: 94%
“…Based on these data, the observed low or nonexistent expression of KIR3DL3 (29) is possibly due to a lack of core promoter elements. In the upstream region of this gene, the sequence between Ϫ40 bp and the ATG is identical with that of KIR3DL1.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, the two KIR genes showing divergence in expression pattern (KIR3DL3 and KIR2DL4) belong to those framework loci with upstream sequences present in unique or divergent regions of the KIR cluster. KIR3DL3 (otherwise known as KIR3DL7 or KIRC1) does not appear to be expressed by the circulating NK cell pool in many donors (29). Most reports indicate that all NK clones and KIR-positive T cell clones express KIR2DL4 transcripts (16,23,24,30,31).…”
mentioning
confidence: 99%
“…ITIM motifs usually couple to phosphatases to promote inhibitory signaling (19). We therefore transfected 293T cells with His-tagged WT or mutant human CLEC12B in combination with SHP-1 or SHP-2.…”
Section: Resultsmentioning
confidence: 99%