Inhibition of neointimal hyperplasia in balloon-induced vascular injuries in a rat model by miR-22 loading Laponite hydrogels

Zheng, Si-si; Zhao, Jing; Chen, Jiawen; Shen, Xiaohua; Hong, Xu-lin; Fu, Guosheng; Fu, Jia-Yin

doi:10.1016/j.bioadv.2022.213140

Cited by 6 publications

(2 citation statements)

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“…Further, Zheng and collaborators have also found that the miR-22 loading laponite hydrogels inhibit the neointimal formation to reduce the infiltration of the macrophages and reverse the adverse vascular ECM remodeling by the upregulation of miR-22 and downregulation of its target genes methyl-CpG binding protein 2 (MECP2), which may offer a novel strategy to treat cardiovascular diseases (Fig. 7 B, C) [ 211 ]. Polymer-based nanofibers also serve as a common delivery vector for gene delivery [ 212 , 213 ].…”

Section: Gene Therapy For Tissue Regenerationmentioning

confidence: 99%

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Advanced gene nanocarriers/scaffolds in nonviral-mediated delivery system for tissue regeneration and repair

Zhang,

Hou,

Yin

et al. 2024

J Nanobiotechnol

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Tissue regeneration technology has been rapidly developed and widely applied in tissue engineering and repair. Compared with traditional approaches like surgical treatment, the rising gene therapy is able to have a durable effect on tissue regeneration, such as impaired bone regeneration, articular cartilage repair and cancer-resected tissue repair. Gene therapy can also facilitate the production of in situ therapeutic factors, thus minimizing the diffusion or loss of gene complexes and enabling spatiotemporally controlled release of gene products for tissue regeneration. Among different gene delivery vectors and supportive gene-activated matrices, advanced gene/drug nanocarriers attract exceptional attraction due to their tunable physiochemical properties, as well as excellent adaptive performance in gene therapy for tissue regeneration, such as bone, cartilage, blood vessel, nerve and cancer-resected tissue repair. This paper reviews the recent advances on nonviral-mediated gene delivery systems with an emphasis on the important role of advanced nanocarriers in gene therapy and tissue regeneration.

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Section: Gene Therapy For Tissue Regenerationmentioning

confidence: 99%

“…( C ) Co-staining of the injured rat common carotid arteries with eNOS and αSMA 14 days after the treatment with the miR-22 loading laponite hydrogels. ( B , C ) Reproduced with permission [ 211 ]. Copyright 2022, Elsevier.…”

Section: Gene Therapy For Tissue Regenerationmentioning

confidence: 99%