Inhibition of neutrophil functions by human immunoglobulin E

Al‐Mohanna, Futwan; Parhar, Ranjit S.; Kawaasi, Aaron; Ernst, Peter B.; Sheth, Kirk; Harfi, Harb A.; Al‐Sedairy, Sultan T.

doi:10.1016/0091-6749(93)90020-g

Cited by 17 publications

(10 citation statements)

References 42 publications

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“…Th2-mediated cytokines, such as IL-4 and IL-13, induce airway inflammation that facilitates microbial attachment to the airway epithelia. In addition, IgE antibodies have been shown to suppress neutrophil adhesion that is an important feature of innate immune responses [21]. The present results show that atopic disease and increased levels of specific IgE are significantly related to the risk of both LRTIs and URTIs.…”

Section: Discussionsupporting

confidence: 52%

Respiratory Infections in Adults with Atopic Disease and IgE Antibodies to Common Aeroallergens

Rantala

Jaakkola

2013

PLoS ONE

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BackgroundAtopic diseases, including allergic rhinitis, allergic dermatitis and asthma, are common diseases with a prevalence of 30–40% worldwide and are thus of great global public health importance. Allergic inflammation may influence the immunity against infections, so atopic individuals could be susceptible to respiratory infections. No previous population-based study has addressed the relation between atopy and respiratory infections in adulthood. We assessed the relation between atopic disease, specific IgE antibodies and the occurrence of upper and lower respiratory infections in the past 12 months among working-aged adults.Methods and FindingsA population-based cross-sectional study of 1008 atopic and non-atopic adults 21–63 years old was conducted. Information on atopic diseases, allergy tests and respiratory infections was collected by a questionnaire. Specific IgE antibodies to common aeroallergens were measured in serum. Adults with atopic disease had a significantly increased risk of lower respiratory tract infections (LRTI; including acute bronchitis and pneumonia) with an adjusted risk ratio (RR) 2.24 (95% confidence interval [CI] 1.43, 3.52) and upper respiratory tract infections (URTI; including common cold, sinusitis, tonsillitis, and otitis media) with an adjusted RR 1.55 (1.14, 2.10). The risk of LRTIs increased with increasing level of specific IgE (linear trend P = 0.059).ConclusionsThis study provides new evidence that working-aged adults with atopic disease experience significantly more LRTIs and URTIs than non-atopics. The occurrence of respiratory infections increased with increasing levels of specific IgE antibodies to common aeroallergens, showing a dose-response pattern with LRTIs. From the clinical point of view it is important to recognize that those with atopies are a risk group for respiratory infections, including more severe LRTIs.

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Section: Discussionsupporting

confidence: 52%

Respiratory Infections in Adults with Atopic Disease and IgE Antibodies to Common Aeroallergens

Rantala

Jaakkola

2013

PLoS ONE

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“…IFN‐ γ is considered a key cytokine of innate and adaptive immunity playing pivotal roles in host defence against microbial pathogens thorough activation of monocytes, macrophages, natural killer (NK) cells, enhancing antigen processing and presentation and modulation of humoral immune response, therefore, its deficiency results in an inappropriate pathogen elimination and in part may explain propensity to skin infections in AD patients (25). On the other hand, increased total IgE levels may lead to the inhibition of skin defence as IgE inhibits neutrophil adhesion, phagocytosis as well respiratory burst (26). Also Th2 cytokines IL‐4 and IL‐13 may increase propensity to S. aureus skin colonisation due the fact, that they can increase expression of fibrynoectin and fibrinogen, receptors that mediate the adhesion S. aureus to stratum corneum (27).…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureusskin colonization in atopic dermatitis children is associated with decreased IFN‐γproduction by peripheral blood CD4⁺and CD8⁺T cells

Machura

Mazur

Golemiec

et al. 2008

Pediatric Allergy Immunology

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Atopic dermatitis (AD) is a chronic inflammatory skin disorder, which is associated with an increased expression of Th2 cytokines with concomitant decrease in IFN-gamma production by circulating CD4+ and CD8+ T cells. The skin of patients with AD is often colonized by Staphylococcus aureus, which may reflect in changes in immunological parameters. The aim of the study was flow cytometric measurement of some peripheral blood lymphocyte subsets expressing naive/memory marker (RA/RO) and activation marker (CD25) as well as intracellular production of IFN-gamma by peripheral blood CD4+ and CD8+ T cells from varied severity AD children and determine the impact of S. aureus skin colonization on cytokines profiles. There was a significant increase in the percentage of CD4+ and CD8+ T cells producing IL-4 and IL-13 and decrease in the percentage of CD4+ and CD8+ T cells producing IFN-gamma upon in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin in children with AD compared to healthy ones. The absolute number of CD4+ and CD8+ T cells expressing memory marker CD45RO was elevated as compared with controls. The severity of AD was positively correlated with the percentage of lymphocyte subsets: CD45RO+, CD4+CD45RO+, and the percentage of CD3+ and CD4+ expressing CD25 as well as the number of S. aureus on the skin. In conclusion, both CD4+ and CD8+ memory T cells are involved in the immunopathogenesis of AD. S. aureus skin colonization is related with disease severity and changes in expression of CD45RO and CD25 on T cells. A decrease in the percentage of CD4+ and CD8+ T cells producing IFN-gamma in AD children may explain propensity for skin infection.

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“…Since we did not determine specific IgE reactivity with staphylococcal antigens, we cannot speculate whether bacteria contributed to the elevation of IgE levels [12, 32]. The relationships between high IgE levels and the persistence of S. aureus colonization could also reflect the direct inhibition of cellular immunity by IgE [20] or by histamine [33]. Such inhibition could be responsible for diminished oxidative burst observed among the patients with persistent staphylococcal colonization [20].…”

Section: Discussionmentioning

confidence: 99%

“…The relationships between high IgE levels and the persistence of S. aureus colonization could also reflect the direct inhibition of cellular immunity by IgE [20] or by histamine [33]. Such inhibition could be responsible for diminished oxidative burst observed among the patients with persistent staphylococcal colonization [20]. In line, in the group of patients with persistent bacterial skin colonization, we noticed the reduced latex‐induced chemiluminescence response of neutrophils, although the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters

Guzik

Bzowska

Kasprowicz³

et al. 2005

Clin Experimental Allergy

130

107

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Inhibition of neutrophil functions by human immunoglobulin E

Cited by 17 publications

References 42 publications

Respiratory Infections in Adults with Atopic Disease and IgE Antibodies to Common Aeroallergens

Respiratory Infections in Adults with Atopic Disease and IgE Antibodies to Common Aeroallergens

Staphylococcus aureusskin colonization in atopic dermatitis children is associated with decreased IFN‐γproduction by peripheral blood CD4⁺and CD8⁺T cells

Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters

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Inhibition of neutrophil functions by human immunoglobulin E

Cited by 17 publications

References 42 publications

Respiratory Infections in Adults with Atopic Disease and IgE Antibodies to Common Aeroallergens

Respiratory Infections in Adults with Atopic Disease and IgE Antibodies to Common Aeroallergens

Staphylococcus aureusskin colonization in atopic dermatitis children is associated with decreased IFN‐γproduction by peripheral blood CD4+and CD8+T cells

Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters

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Staphylococcus aureusskin colonization in atopic dermatitis children is associated with decreased IFN‐γproduction by peripheral blood CD4⁺and CD8⁺T cells