Inhibition of Newcastle disease virion messenger RNA (guanine-7-)-methyltransferase by analogs of S-adenosylhomocysteine

Effect of undermethylation on mRNA cytoplasmic appearance and half-life.

“…Although STH does inhibit the (guanine-7)-methyltransferases of Newcastle disease virus and vaccinia virus in vitro (24,25), it apparently did not inhibit m7G formation in Novikoff cells (19).…”

Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy.

“…Lymphocytotoxicity of this compound could be mediated in part through this mechanism. Secondly, inhibition of transmethylation reactions could have significance as a mechanism of antiviral action for ara-A, especially because inhibition of transmethylation reactions has established antiviral properties (8)(9)(10)(11)(12). Whereas no specific data is presented here to implicate this pathway as the antiviral mechanism, the in vivo potential for transmethylation inhibition is provided by Ado-Hcy inactivation.…”

“…Because other methylation inhibitors possess antiviral activity (8)(9)(10)(11)(12), and methylation reactions are widely distributed in intermediary metabolism (13), it is possible that this property could contribute to the antiviral action and systemic toxicity of ara-A. To clarify whether Ado-Hcy hydrolase inactivation occurs during ara-A therapy, and the kinetics of this reaction in vivo, we have examined the alterations of Ado-Hcy hydrolase during low-dose therapy of chronic hepatitis B virus infection.…”

A Tribute to Ronald T. Borchardt—Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

“…[53][54][55][56] The development of PNMT inhibitors and protein carboxyl methyltransferase arose from fruitful collaborations with fellow KU faculty members Professors Gary Grunewald and Charles O. Rutledge, respectively.…”