2006
DOI: 10.1007/s11010-006-1737-4
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Inhibition of nitric oxide and caspase-3 mediated apoptosis by a tetrapeptide derivative (PEP1261) in cultured synovial fibroblasts from collagen-induced arthritis

Abstract: In this study, the effect of (Boc-Lys (Boc)-Arg-Asp-Ser (tBu)-OtBu), a tetrapeptide derivative (PEP1261) was examined for antiproliferative potency and apoptotic induction. Synovial fibroblasts were isolated from collagen-induced arthritic (CIA) rats and exposed to peptides viz., PEP1261, and parental peptides (KRDS and RGDS). Viability of the cells decreased in the presence of PEP1261 at a lower concentration (0.1 mM) when compared to RGDS and KRDS (1 mM). The treatment of cells with peptides showed induction… Show more

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Cited by 7 publications
(1 citation statement)
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“…Increased NO level may inhibit the synovial fibroblasts apoptotic cell death by restricting the activation caspase-3 by nitrosylation of thiol group, and this action leads to RA pathogenesis. (24) The activated HIG-82 cells by PMA secrete prostaglandin E2 (PGE2) into their culture medium.…”
Section: Discussionmentioning
confidence: 99%
“…Increased NO level may inhibit the synovial fibroblasts apoptotic cell death by restricting the activation caspase-3 by nitrosylation of thiol group, and this action leads to RA pathogenesis. (24) The activated HIG-82 cells by PMA secrete prostaglandin E2 (PGE2) into their culture medium.…”
Section: Discussionmentioning
confidence: 99%