Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract

Pergola, Carlo; Rossi, Antonietta; Dugo, Paola; Cuzzocrea, Salvatore; Sautebin, Lidia

doi:10.1016/j.niox.2005.10.003

Cited by 139 publications

(103 citation statements)

References 41 publications

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“…Among various targets of MAPK, NF-jB is an important one [20,21]. Many independent lines of evidence suggest that different types of MAPKs can be activated in macrophages in response to LPS [29][30][31]. Such results were confirmed in the present study.…”

Section: Discussionsupporting

confidence: 89%

Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-κB in macrophages

2009

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Section: Discussionsupporting

confidence: 89%

Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-κB in macrophages

2009

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“…These effects were not seen in the long term, however [63]. Other inhibitors of NF-κB activation include nonsteroidal anti-inflammatory drugs [64], corticosteroids [56], metformin [65], herbal extracts [66][67][68], and even moderate alcohol intake [69]. The above findings thus confirm an important role for NF-κB activation in a number of scenarios leading to tissue damage.…”

Section: Inflammation and Atherosclerosismentioning

confidence: 67%

Obstructive sleep apnea, cardiovascular disease, and inflammation—is NF-κB the key?

2007

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Obstructive sleep apnea (OSA) affects a large portion of the population and is associated with repeated airway collapse leading to chronic intermittent hypoxia, exaggerated swings in intrathoracic pressure and post apneic arousal. OSA is associated with heightened sympathoadrenal tone and is a risk factor for cardiovascular mortality and morbidity. In addition to well-known mechanical and autonomic effects, OSA appears to be associated with systemic inflammation. This could provide one mechanism leading to cardiovascular disease (CVD). A central factor in the inflammatory cascade is nuclear factor kappa B (NF-kappaB), which is involved in the transcription of numerous genes involved in the inflammatory cascade. The object of this article is to review recent literature on some of the aspects of OSA related to a proinflammatory state and the possible role of NF-kappaB as one mechanism providing a link between sleep apnea and CVD.

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“…Vascular endothelial growth factor (VEGF) is a major pro-angiogenic and proatherosclerotic factor but anthocyanins have been shown to prevent the expression of VEGF in vascular smooth muscle cells (Oak et al 2006). In macrophages, blackberry anthocyanins inhibit LPS induced nitric oxide biosynthesis (Pergola et al 2006). Anthocyanins also inhibit TRAP-induced platelet aggregation but do not influence platelet reactivity when faced with strong agonists such as collagen and ADP (Rechner and Kroner 2005).…”

Section: Biological Activitymentioning

confidence: 99%

Anthocyanins: from plant to health

2007

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Anthocyanins are a group of natural occurring pigments responsible for the red-blue colour of many fruits and vegetables. Anthocyanins are of interest for two reasons because they cannot only be used in the technological field as natural colorants but also have important implications in the field of human health. Numerous studies indicate the potential effect that this family of flavonoids may have in reducing the incidence of cardiovascular disease, cancer, hyperlipidemias and other chronic diseases through the intake of anthocyanin-rich foods. This review examines existing literature in this area: from plant content and distribution to health implications, including the effect of agronomic and genetic modifications on the anthocyanin content of plants as well as other biotechnological factors and food processing. The bioavailability, metabolism, bioactivity, and epidemiology of anthocyanins will also be reviewed.

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Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract

Cited by 139 publications

References 41 publications

Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-κB in macrophages

Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-κB in macrophages

Obstructive sleep apnea, cardiovascular disease, and inflammation—is NF-κB the key?

Anthocyanins: from plant to health

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