Inhibition of Nitric Oxide Synthase Attenuates Cutaneous Vasodilation During Warm Moxibustion-Like Thermal Stimulation in Humans

Kimura, Ken‐ichi; Takeuchi, Hayato; Yuri, Kuniko; Wakayama, Ikuro

doi:10.1089/acm.2011.0433

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…The long-distance effect of moxibustion may be due to neural reflexes [25], whereas local effects are mediated through cytokines and signal transduction. The present study and previous studies have revealed moxibustion activates a unique cytokine profile and signal transduction pathways [22, 27–34, 42, 43], as well as elevating macrophage autophagy (Figure 1) and natural killer cell activity [34]. These results suggest moxibustion generates a protective response against viral and bacterial infection, although it is not clear whether it functions locally or systemically.…”

Section: Discussionsupporting

confidence: 66%

Moxibustion Activates Macrophage Autophagy and Protects Experimental Mice against Bacterial Infection

Guo

Shen

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Moxibustion is one of main therapies in traditional Chinese medicine and uses heat stimulation on the body surface from the burning of moxa to release pain or treat diseases. Emerging studies have shown that moxibustion can generate therapeutic effects by activating a series of signaling pathways and neuroendocrine-immune activities. Here we show moxibustion promoted profound macrophage autophagy in experimental Kunming mice, with reduced Akt phosphorylation and activated eIF2α phosphorylation. Consequently, moxibustion promoted bacterial clearance by macrophages and protected mice from mortality due to bacterial infection. These results indicate that moxibustion generates a protective response by activating autophagy against bacterial infections.

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Section: Discussionsupporting

confidence: 66%

Moxibustion Activates Macrophage Autophagy and Protects Experimental Mice against Bacterial Infection

Guo

Shen

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Local inhibition of nitric oxide attenuates cutaneous vasodilator responses during postmenopausal hot flashes [ 38 ]. Otherwise, skin temperature, core body temperature, heart rate (HR), and blood pressure during warm moxibustion-like thermal stimulation at the site perfused with L-NAME were significantly decreased in healthy people [ 39 ]. These reports demonstrate that NO which is involved in the mechanism of visceral or local tissue vasodilation can be inhibited by L-NAME.…”

Section: Discussionmentioning

confidence: 99%

Effects of Electroacupuncture Stimulation at “Zusanli” Acupoint on Hepatic NO Release and Blood Perfusion in Mice

Wang

Zhang

Tang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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The study is to observe the influence of electroacupuncture (EA) stimulation at “Zusanli” (ST36) on the release of nitric oxide (NO) and blood perfusion (BP) in the liver and further explore whether the hepatic blood perfusion (HBP) changes were regulated by EA ST36 induced NO in nitric oxide synthase inhibited mice. The HBP change of the mice was detected by laser speckle perfusion imaging (LSPI) before and after being given interventions, and the NO in liver tissue was detected by nitric acid reductase in each group. The NO levels and HBP in the L-NAME group were significantly lower than those in the control group (P < 0.01). The NO level and HBP increase in EA group were significantly higher than those in control group (P < 0.05). The NO level in the L-NAME EA group was slightly higher than that in the L-NAME group. The HBP increase in the L-NAME EA group was not statistically significant. These results showed that EA could accelerate the synthesis of NO and thereby increase HBP via vasodilation in liver tissue.

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“…We have also recently demonstrated that NO is involved in the mechanisms of cutaneous vasodilation during warm moxibustion in the forearms of humans. 8 Thus, the local vasodilative reaction at the stimulation site may be induced by vasodilative substances, such as CGRP, released from sensory nerve endings through the axon reflex, but NO production may also be important. The mechanisms of cutaneous vasodilation are complex and many points remain unclear with regard to the action caused by acupuncture stimulation.…”

Section: Introductionmentioning

confidence: 99%

Effects of Nitric Oxide Synthase Inhibition on Cutaneous Vasodilation in Response to Acupuncture Stimulation in Humans

et al. 2013

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Inhibition of Nitric Oxide Synthase Attenuates Cutaneous Vasodilation During Warm Moxibustion-Like Thermal Stimulation in Humans

Abstract: These data demonstrate that NO is involved in the mechanism of cutaneous vasodilation induced by WMTS. Furthermore, increases in CVC despite inhibition of the COX pathway suggest that PG does not contribute to cutaneous vasodilation during WMTS.

Cited by 5 publications

References 20 publications

Moxibustion Activates Macrophage Autophagy and Protects Experimental Mice against Bacterial Infection

Moxibustion Activates Macrophage Autophagy and Protects Experimental Mice against Bacterial Infection

Effects of Electroacupuncture Stimulation at “Zusanli” Acupoint on Hepatic NO Release and Blood Perfusion in Mice

Effects of Nitric Oxide Synthase Inhibition on Cutaneous Vasodilation in Response to Acupuncture Stimulation in Humans

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