Inhibition of noradrenaline uptake2 in the isolated rat heart by steroids, clonidine and methoxylated phenylethylamines

Salt, P.J.

doi:10.1016/0014-2999(72)90194-x

Cited by 211 publications

(101 citation statements)

References 20 publications

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“…17,B-Oestradiol, progesterone, testosterone, corticosterone, deoxycorticosterone and cortisol-HS are potent inhibitors of extraneuronal catecholamine uptake (Kalsner, 1969;Salt, 1972;Cornish etal., 1978) Of these steroids, only 17p-oestradiol is known also to inhibit the neuronal uptake of catecholamines (Iversen & Salt, 1970;Salt, 1972;Cornish et al, 1978). Normetanephrine (4-22 ElM) is known to inhibit selectively extraneuronal uptake by approximately 50% (Burgen & Iversen, 1965;Mireyless & Foster, 1973;Major, Sauerwein & Graefe, 1978).…”

Section: Discussionmentioning

confidence: 99%

Effect of steroids on β‐adrenoceptor‐mediated relaxation of pig bronchus

Foster

Goldie

Paterson

1983

British J Pharmacology

111

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Section: Discussionmentioning

confidence: 99%

Effect of steroids on β‐adrenoceptor‐mediated relaxation of pig bronchus

Foster

Goldie

Paterson

1983

British J Pharmacology

111

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“…We showed that Mg 2ϩ affects NE release but not uptake by using uptake blockers such as cocaine 16 and deoxycorticosterone. 17 To specify Mg 2ϩ effect on Ca 2ϩ channels that play a pivotal role in sympathetic activity, we used NGF-treated PC12 cells. NGF-treated PC12 cells exhibited neurite outgrowth.…”

Section: Mgmentioning

confidence: 99%

Magnesium Inhibits Norepinephrine Release by Blocking N-Type Calcium Channels at Peripheral Sympathetic Nerve Endings

et al. 2004

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Abstract-AlthoughMg 2ϩ contributes to blood pressure regulation partly in terms of vasodilator action, its sympatholytic effect may also play an important role to control blood pressure. Thus, in the present study, we investigated the effect of Mg 2ϩ on sympathetic tone and blood pressure. We studied its actions on the blood pressure response to hydralazine, a direct vasodilator, in conscious spontaneously hypertensive rats (SHRs), and to electrical stimulation in the pithed Sprague-Dawley rat; catecholamine release by peripheral sympathetic nerve endings; and the N-type MethodsFor a detailed Methods section, please see http://hyper.hypertensionaha.org.All protocols in this study were approved by the ethics committee of our institution, and rats were handled in our accredited facility in accordance with the institutional animal care policies of the University of Tokyo. All research protocols conformed to the guiding principles for animal experimentation as enunciated by the Ethics Committee on Animal Research of the University of Tokyo, Faculty of Medicine. Protocol 1: Sympatholytic Effect of Mg 2؉ and Blood Pressure Changes In VivoMale spontaneously hypertensive rats were used in this experiment. The rats were divided into 2 groups: Mg 2ϩ group (nϭ8) and a control group (nϭ7). In the Mg 2ϩ group, MgSO 4 (3ϫ10 Ϫ6 mol/kg body weight/min) was infused, and in the control group saline was infused. Responses to hydralazine (1, 3, and 6ϫ10Ϫ5 g/kg body weight) were observed. A 100 L blood sample was drawn before and after saline or MgSO 4 infusion to measure the serum Mg level. The nadir mean

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“…Norepinephrine overflow by nerve stimulation in the presence of deoxycorticosterone (10~5 M), a specific uptake II blocker, 24 is defined as the difference between norepinephrine content of perfusates for 5-minute periods before and after the nerve stimulation. Fractional norepinephrine overflow is given as the ratio of the amount of norepinephrine present in the perfusate divided by the norepinephrine content of the tissue.…”

Section: Release Of Endogenous Norepinephrine and Vascular Reactivitymentioning

confidence: 99%

Norepinephrine overflow in perfused mesenteric arteries of spontaneously hypertensive rats.

Hano

Rho

1989

Hypertension

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We examined the overflow of endogenous norepinephrine with electrical stimulation, the associated pressor response, and rate of initial neuronal uptake of [ 3 H] norepinephrine in perfused mesenteric arteries of 7-and 13-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. The tissues of two rats, a spontaneously hypertensive and a WKY control rat, were simultaneously processed and subjected to the same electrical stimulation. Both absolute and fractional overflow of endogenous norepinephrine during periarterial nerve stimulation (5 and 10 Hz for 1 minute) in the tissue of 7-week-old SHR was significantly greater whereas overflow of 13-week-old SHR was equivalent as compared with that of the age-matched WKY rats. The tissue content of norepinephrine was 20-25% higher in SHR of both ages. There was significantly enhanced [ 3 H] norepinephrine uptake in the tissues of young SHR, but no difference was observed in the older SHR. The pressor response to periarterial nerve stimulation was significantly enhanced in 7-week-old SHR and much more so at the older age as compared with the WKY control rats. Exogenous norepinephrine dose-response curves in the tissues of 7-week-old SHR exhibited a parallel leftward shift, characteristic of a change in sensitivity, whereas that of 13-week-old SHR showed a much steeper slope as compared with the respective WKY control rats. This finding suggests that in addition to smooth muscle supersensitivity, structural alterations had occurred in vasculature of 13-week-old SHR. These data indicate that in SHR both the exocytotic release of norepinephrine and the responsiveness of the vascular smooth muscle cells are enhanced in the developmental stage of hypertension whereas smooth muscle supersensitivity to norepinephrine and nonspecific structural alterations primarily contribute to the maintenance of hypertension at 13 weeks of age. {Hyperten-sion 1989;14:44-53)

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Inhibition of noradrenaline uptake2 in the isolated rat heart by steroids, clonidine and methoxylated phenylethylamines

Cited by 211 publications

References 20 publications

Effect of steroids on β‐adrenoceptor‐mediated relaxation of pig bronchus

Effect of steroids on β‐adrenoceptor‐mediated relaxation of pig bronchus

Magnesium Inhibits Norepinephrine Release by Blocking N-Type Calcium Channels at Peripheral Sympathetic Nerve Endings

Norepinephrine overflow in perfused mesenteric arteries of spontaneously hypertensive rats.

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