Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine

Sun, Siyuan; Wang, Kai; Lei, Hongmei; Li, Liping; Tu, Meijuan; Zeng, Su; Zhou, Hui; Jiang, Huidi

doi:10.1016/j.pnpbp.2013.11.005

Cited by 55 publications

(29 citation statements)

References 38 publications

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“…Therefore, it can be concluded that berberine exerts antidepressant‐like effect in mice probably via modulating brain biogenic amines (serotonin, norepinephrine, and dopamine) and nitric oxide pathway (Kulkarni and Dhir, ). In another study, it has been shown that berberine is a substrate and also an inhibitor of OCT2 and OCT3, and its inhibition on OCT2‐mediated and OCT3‐mediated NE and 5‐HT uptake may contribute to the increased monoamine concentration in mouse brain (Sun et al ., ).…”

Section: Central Nervous System Effectsmentioning

confidence: 99%

Berberis Vulgaris and Berberine: An Update Review

Imenshahidi

Hosseinzadeh

2016

Phytotherapy Research

264

180

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Berberine is an isoquinoline alkaloid present in several plants, including Coptis sp. and Berberis sp. Berberine is a customary component in Chinese medicine, and is characterized by a diversity of pharmacological effects. An extensive search in electronic databases (PubMed, Scopus, Ovid, Wiley, ProQuest, ISI, and Science Direct) were used to identify the pharmacological and clinical studies on Berberis vulgaris and berberine, during 2008 to 2015, using 'berberine' and 'Berberis vulgaris' as search words. We found more than 1200 new article studying the properties and clinical uses of berberine and B. vulgaris, for treating tumor, diabetes, cardiovascular disease, hyperlipidemia, inflammation, bacterial and viral infections, cerebral ischemia trauma, mental disease, Alzheimer disease, osteoporosis, and so on. In this article, we have updated the pharmacological effects of B. vulgaris and its active constituent, berberine. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Central Nervous System Effectsmentioning

confidence: 99%

Berberis Vulgaris and Berberine: An Update Review

Imenshahidi

Hosseinzadeh

2016

Phytotherapy Research

264

180

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“…BBR is widely distributed and inexpensive, so clinical and academic institutions conducted extensive research on it. In recent years, with the in‐depth study of BBR, BBR has been found to have a wide range of pharmacological effects (Imenshahidi & Hosseinzadeh, ), including hypoglycemic (Pang et al, ), hypolipidemic (Li, Jiang, & Kong, ), hypotension (Guo, Sun, Zhang, & Zhang, ), antidepressant (Sun et al, ), anti‐inflammatory (Liu, Yin, Ding, Wang, & Wang, ), antiviral (Shin et al, ), antibacterial (Peng et al, ), and antiparasitic (Dkhil, ), and other pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Anti‐influenza activity of berberine improves prognosis by reducing viral replication in mice

Yan

et al. 2018

Phytotherapy Research

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Berberine, a natural isoquinoline alkaloid isolated from the berberis species, has a wide array of biological properties such as anti-inflammatory, antibacterial, antifungal, and antihelminthic effects. We evaluated the antiviral effect of berberine against influenza A/FM1/1/47 (H1N1) in vivo and in vitro. The results showed that berberine strongly suppressed viral replication in A549 cells and in mouse lungs. Meanwhile, berberine relieved pulmonary inflammation and reduced necrosis, inflammatory cell infiltration, and pulmonary edema induced by viral infection in mice when compared with vehicle-treated mice. Berberine suppressed the viral infection-induced up-regulation of TLR7 signaling pathway, such as TLR7, MyD88, and NF-κB (p65), at both the mRNA and protein levels. Furthermore, berberine significantly inhibited the viral infectioninduced increase in Th1/Th2 and Th17/Treg ratios as well as the production of inflammatory cytokines. Our data provide new insight into the potential of berberine as a therapeutic agent for viral infection via its antiviral activity.

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“…It was reported that several organic cation transporters (OCTs) are low-affinity transporters of monoamines, 2,3) and the inhibition of OCTs as well as the high-affinity monoamine transporters including the serotonin transporter (SERT) and norepinephrine transporter (NET) may be in part involved in the pharmacological effects of antidepressants. 4,5) OCTs include OCT1/SLC22A1, OCT2/ SLC22A2, and OCT3/SLC22A3 and are polyspecific transporters for various types of organic cations. Carnitine/organic cation transporters (OCTNs) are another type of OCT and include OCTN1/SLC22A4 and OCTN2/SLC22A5.…”

Section: Introductionmentioning

confidence: 99%

Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells

Nakamichi

Kato

2017

Biological & Pharmaceutical Bulletin

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Dysfunction in neurotransmission mediated by neurotransmitters causes various neurological disorders.Therefore, receptors and reuptake transporters of neurotransmitters have been focused on as a therapeutic target in neurological disorders. These membrane proteins have high affinity for a specific neurotransmitter and are highly expressed on synaptic membranes. In contrast, xenobiotic transporters have relatively lower affinity for neurotransmitters but widely recognize various organic cations and/or anions and are also expressed in brain neurons. However, it has been largely unknown why such xenobiotic transporters are expressed in neurons that play a key role in signal transduction. We have therefore attempted to clarify the physiological roles of one such xenobiotic organic cation transporter (OCT) in neural cells with the aim of obtaining new insight into the treatment of neurological disorders. Carnitine/organic cation transporter OCTN1/SLC22A4 is functionally expressed in neurons and neural stem cells. In particular, OCTN1 is expressed at much higher levels compared with other OCTs in neural stem cells and positively regulates their differentiation into neurons. OCTN1 accepts the naturally occurring food-derived antioxidant ergothioneine (ERGO) as a good in vivo substrate. Because ERGO is highly distributed into the brain after oral ingestion, OCTN1 may contribute to the alleviation of oxidative stress and promotion of neuronal differentiation via the uptake of ERGO in the brain, perhaps abating symptoms of neurological disorders. In this review, we introduce current topics on the physiological roles of OCTs with a focus on OCTN1 in neural cells and discuss its possible application to the treatment of neurological disorders.

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Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine

Cited by 55 publications

References 38 publications

Berberis Vulgaris and Berberine: An Update Review

Berberis Vulgaris and Berberine: An Update Review

Anti‐influenza activity of berberine improves prognosis by reducing viral replication in mice

Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells

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