Inhibition of penile erection in rats by a long‐acting somatostatin analogue, octreotide (SMS 201–995)

Kapicioğlu, S.; Mollamehmetoglu, M; Kutlu, Necíp; Can, Gülşen; Ozgur, Gokhan

doi:10.1046/j.1464-410x.1998.00520.x

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…This effect is probably similar to the inhibitory effects of somatostatin on serotonin secretion in the gut, believed to generally antagonize the biogenic amine release from neuroendocrine cells . Potential support of somatostatin's inhibition on sexual arousal is the finding that octreotide, a somatostatin agonist, inhibits erection in male rats .…”

Section: Other Possible Chemoreceptor Regulatorsmentioning

confidence: 83%

Evolving ideas about the male refractory period

Turley

Rowland

2013

BJU International

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• The male refractory period (MRP) continues to be a topic of discussion and debate within the field of sexual medicine. To date explanations rely on central descending (efferent) influences involving specific neurotransmitter systems. Herein we explore the issue of the male refractory period, identifying problems with current explanations, specifying the parameters of an adequate model, and suggesting possible mechanisms mediating this phenomenon.• We review the literature regarding existing explanations for the MRP and look to other systems of physiological regulation that might provide a model for the conceptualization of the MRP.• Our approach differs from traditional explanations in that it emphasizes the possible roles of various peripheral, rather than central, feedback (afferent) systems that affect peripheral autonomic functioning and response.• Yet our approach is consistent with other peripheral regulatory feedback systems controlling autonomic response related to such processes as heart rate, respiration, and gut motility.• Although direct empirical research supporting our approach is lacking, sufficient evidence exists to support the idea that such processes are not only possible but likely with respect to the male refractory period. We suggest several lines of research that might provide empirical support for this approach.

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Section: Other Possible Chemoreceptor Regulatorsmentioning

confidence: 83%

Evolving ideas about the male refractory period

Turley

Rowland

2013

BJU International

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“…In addition, cabergoline has proven effective in restore fertility in men with iperPRL due to micro- and macro-prolactinomas [ 51 ], but the effects of dopamine agonists on sexual health of men with acromegaly have not been studied. Conversely, the somatostatin analogue octreotide may have a negative effect on erectile function, as suggested by the inhibition of penile erection in rats [ 52 ] but there are currently no reports on humans. Similarly, octreotide transiently decreased sperm motility in stallions [ 53 ], but human data are lacking.…”

Section: Medication For Acromegaly and Male Sexual Healthmentioning

confidence: 99%

Acromegaly and male sexual health

Salvio

Martino

Balercia

et al. 2022

Rev Endocr Metab Disord

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Acromegaly is a rare pathology characterized by chronic hypersecretion of Growth Hormone (GH) and Insulin-like Growth Factor-1 (IGF-1) that causes somatic, metabolic, and systemic changes. The somatotropic axis acts physiologically favoring gonadal function, but when GH is produced in excess it has deleterious effects on many aspects of male sexuality. It is widely demonstrated, in fact, that acromegaly induces hypogonadism through different mechanisms, both through direct mass effect on gonadotropic cells and through increased plasma levels of prolactin. Moreover, hypogonadism is also one of the factors linking acromegaly to erectile dysfunction (ED), but also metabolic complications of acromegaly and, probably, GH itself contribute to the genesis of this disorder. There are few data in the literature on the impact of the disease on fertility and testicular volume. Finally, knowledge of the role of GH hypersecretion on the occurrence of prostatic diseases such as benign prostatic hypertrophy and prostatic cancer appears to be of fundamental clinical importance in the long-term management of these patients.

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Effects of Sleep Deprivation by Olfactorily Induced Sexual Arousal Compared to Immobilization Stress and Manual Sleep Deprivation on Neuromessengers and Time Keeping Genes in the Suprachiasmatic Nuclei and Other Cerebral Entities of Syrian Hamsters—An Immunohistochemical Study

Knöchel

Frickmann

Nürnberger

2021

IJERPH

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We investigated the effects of sexual arousal induced by olfactory stimuli on the expression of neuromodulators, neurotransmitters and sexual steroid receptors in the suprachiasmatic nucleus (SCN, the circadian pacemaker of mammals) and other cerebral entities of Syrian hamsters (Mesocricetus auratus) compared to manual sleep deprivation and immobilization stress. The hamsters kept under a 12:12 hours (h) light:dark cycle were deprived of sleep by sexual stimulation, gentle manual handling or immobilization stress for 1 h at the beginning of the light phase and subsequently sacrificed at zeitgeber time 01:00, respectively; for comparison, hamsters were manually sleep deprived for 6 or 20 h or sacrificed after completing a full sleep phase. As demonstrated by immunohistochemistry, apart from various alterations after manual sleep deprivation, sexual stimulation caused down-regulation of arginine-vasopressin (AVP), vasointestinal peptide (VIP), serotonin (5-HT), substance P (SP), and met-enkephalin (ME) in the SCN. Somatostatin (SOM) was diminished in the medial periventricular nucleus (MPVN). In contrast, an increase in AVP was observed in the PVN, that of oxytocin (OXY) in the supraoptic nucleus (SON), of tyrosine-hydroxylase (TH) in the infundibular nucleus (IN), and dopamine beta-hydroxylase (DBH) in the A7 neuron population of the brain stem (A7), respectively. Testosterone in plasma was increased. The results indicate that sexual arousal extensively influences the neuropeptide systems of the SCN, suggesting an involvement of the SCN in reproductive behavior.

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Inhibition of penile erection in rats by a long‐acting somatostatin analogue, octreotide (SMS 201–995)

Cited by 3 publications

References 30 publications

Evolving ideas about the male refractory period

Evolving ideas about the male refractory period

Acromegaly and male sexual health

Effects of Sleep Deprivation by Olfactorily Induced Sexual Arousal Compared to Immobilization Stress and Manual Sleep Deprivation on Neuromessengers and Time Keeping Genes in the Suprachiasmatic Nuclei and Other Cerebral Entities of Syrian Hamsters—An Immunohistochemical Study

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