Inhibition of Pentagastrin-Stimulated and Nocturnal Gastric Secretion by Ranitidine

Peden, N. R.; Saunders, Jimmy; Wormsley, K. G.

doi:10.1016/s0140-6736(79)91146-2

Cited by 99 publications

(30 citation statements)

References 4 publications

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“…These results are in accord with the present in vitro studies and previous reports that metiamide and cimetidine possess a similar level of activity (Brimblecombe et al, 1975). Other studies have shown ranitidine to inhibit gastric acid secretion in the dog (Bradshaw et al, 1979;Daly, Humphray & Stables, 1980) and man (Peden, Saunders & Wormsley, 1979).…”

Section: In Vivo Antisecretory Experimentsmentioning

confidence: 89%

SOME in vitro AND in vivo ACTIONS OF THE NEW HISTAMINE H₂‐RECEPTOR ANTAGONIST, RANITIDINE

Daly

Humphray

Stables

1981

British J Pharmacology

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IRanitidine has been investigated as an antagonist of the H2-receptor-mediated responses to histamine of guinea-pig atrium and rat uterus in vitro and as an inhibitor of gastric acid secretion in the rat.2 Ranitidine competitively antagonized histamine-induced increases in contraction frequency of the guinea-pig isolated right atrium. Ranitidine had a pA2 of 7.2 and was 7.9 and 4.5 times more potent than metiamide and cimetidine respectively. 3 Ranitidine competitively antagonized histamine-induced relaxations of the rat isolated uterine horn. Ranitidine had a pA2 of 6.95 and was 3.6 and 5.9 times more potent than metiamide and cimetidine respectively. 4 Ranitidine, even at high concentrations, did not affect responses of the guinea-pig isolated atrium or rat isolated uterus to (--isoprenaline. Similarly it was without effect on either histamine or bethanechol-induced contractions of guinea-pig isolated ileum. 5 Ranitidine inhibited histamine-and pentagastrin-induced gastric acid secretion in the perfused stomach preparation of the anaesthetized rat. Ranitidine was 5.2 and 7.0 times more potent on a molar basis than metiamide and cimetidine respectively, as an inhibitor of histamine-induced gastric acid secretion. 6 It is concluded that ranitidine is a potent, competitive and selective antagonist of histamine at H2-receptor sites and an effective inhibitor of gastric acid secretion in vivo.

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Section: In Vivo Antisecretory Experimentsmentioning

confidence: 89%

SOME in vitro AND in vivo ACTIONS OF THE NEW HISTAMINE H₂‐RECEPTOR ANTAGONIST, RANITIDINE

Daly

Humphray

Stables

1981

British J Pharmacology

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“…When administered in man, the dose of pyridostigmine is normally 4-5 times greater than neostigmine, due to differences in their potency. Experimental evidence suggests that the half-life of larger doses of pyridostigmine is prolonged (Baker et al, 1978) This drug is reported to be several times more potent than cimetidine on a molar basis (Peden, Saunders & Wormsley, 1979;Domschke, Lux, Domschke & Demling, 1979) and, hence, the theoretical possibility exists that this more potent drug may cause pancreatic damage.…”

Section: Kinetics Of Intravenous Pyridostigmine In Manmentioning

confidence: 99%

Kinetics of intravenous pyridostigmine in man.

Calvey¹,

Chan²,

Dehghan³

et al. 1981

Brit J Clinical Pharma

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“…Peptic ulcer is a common disease worldwide, with an estimated 10% of the population effected. Research has shown that the infection of Helicobacter pylori is a key factor in the occurrence and reoccurrence of peptic ulcer [8,9] . Tiemonium Methylsulfate (Figure 2) is chemically described as 4-(3-hydroxy-3-phenyl-3-(2-thienyl) propyl)-4-methyl morpholinium methylsulfate (salt).…”

Section: Introductionmentioning

confidence: 99%

Quantitative and Qualitative Estimation of Three Marketed Tablet Preparations of Ranitidine Hydrochloride, Tiemonium Methylsulfate and Domperidone Commonly Used in Bangladesh

Sohel¹

2017

JPP

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This study was aimed to evaluate the pharmaceutical quality of ranitidine hydrochloride, tiemonium methylsulfate and domperidone tablets manufactured in Bangladesh. Ten samples of Ranitidine Hydrochloride, Tiemonium Methylsulfate and Domperidone solid dosage forms available in Bangladesh drug market were assayed spectrophotometrically and their various physical parameters such as weight variation, friability, disintegration, dissolution and hardness were analyzed according to British Pharmacopoeia (BP) and United States Pharmacopoeia (USP). Among them seven ranitidine, seven timonium and seven domperidone samples were meet the BP specification (95 -105% of claimed potency). Study revealed that eight ranitidine, ten tiemonium and seven domperidone formulations of different companies meet the USP specification for in vitro dissolution test in first 30 minutes.

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Inhibition of Pentagastrin-Stimulated and Nocturnal Gastric Secretion by Ranitidine

Cited by 99 publications

References 4 publications

SOME in vitro AND in vivo ACTIONS OF THE NEW HISTAMINE H₂‐RECEPTOR ANTAGONIST, RANITIDINE

SOME in vitro AND in vivo ACTIONS OF THE NEW HISTAMINE H₂‐RECEPTOR ANTAGONIST, RANITIDINE

Kinetics of intravenous pyridostigmine in man.

Quantitative and Qualitative Estimation of Three Marketed Tablet Preparations of Ranitidine Hydrochloride, Tiemonium Methylsulfate and Domperidone Commonly Used in Bangladesh

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Inhibition of Pentagastrin-Stimulated and Nocturnal Gastric Secretion by Ranitidine

Cited by 99 publications

References 4 publications

SOME in vitro AND in vivo ACTIONS OF THE NEW HISTAMINE H2‐RECEPTOR ANTAGONIST, RANITIDINE

SOME in vitro AND in vivo ACTIONS OF THE NEW HISTAMINE H2‐RECEPTOR ANTAGONIST, RANITIDINE

Kinetics of intravenous pyridostigmine in man.

Quantitative and Qualitative Estimation of Three Marketed Tablet Preparations of Ranitidine Hydrochloride, Tiemonium Methylsulfate and Domperidone Commonly Used in Bangladesh

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Product

Resources

About

SOME in vitro AND in vivo ACTIONS OF THE NEW HISTAMINE H₂‐RECEPTOR ANTAGONIST, RANITIDINE

SOME in vitro AND in vivo ACTIONS OF THE NEW HISTAMINE H₂‐RECEPTOR ANTAGONIST, RANITIDINE