Inhibition of Peritonitis by Amide Local Anesthetics

Rimbäck, Gunnar; Cassuto, Jean; Wallin, Gunnar; Westlander, Göran

doi:10.1097/00000542-198812000-00013

Cited by 89 publications

(47 citation statements)

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“…The increased weight gain in animals submitted to local anesthesia might be related to the reduction in pain produced by the antinociceptive, antiinflammatory, and antimicrobial effects of local anesthesia (RIMBÄCK et al, 1988;SAKURAGI et al, 1998;PERE et al, 1999;BATAI, 2002;CASSUTO et al, 2006). It is well known that the greater the weight gain at weaning, the greater the weight at slaughtering and the greater the profit to the producer LEPINE, 1991;MAHAN et al, 1998;WOLTER;ELLIS, 2001).…”

Section: Discussionmentioning

confidence: 99%

Weight gain, behavioral and cortisol changes after orchiectomy with or without local anaesthesia in piglets

Barticciotto

Luna

Lorena

et al. 2016

SCA

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The aim of this study was to investigate the effect of intratesticular local anesthesia on weight gain and behavioral and cortisol changes in piglets submitted to castration. Study design was a randomized controlled trial. Twenty-nine male Landrace crossbred piglets aged 3 to 6 days were used. The piglets were randomly divided into two groups: orchiectomy with anesthesia (A, n = 15) and orchiectomy without anesthesia (NOA, n = 14). Piglets in the A and NOA groups were treated with 0.5 mL of intratesticular 2% lidocaine with a vasoconstrictor in each testicle and 0.5 mL of intratesticular 0.9% sodium chloride, respectively. Blood samples were collected from all animals immediately after surgery and at 3 and 6 days postoperatively for measurement of the serum cortisol concentration. Behavior was assessed daily for 6 days by two observers blinded to the treatment. Weight was measured at the same time as cortisol measurement. Analysis of variance followed by the Student-Newman-Keuls test was used to investigate differences in time within and between the two groups. Mean times of six evaluations done for 90 minutes during 6 days of each behavior were compared by Tukey t test. The level of statistical significance was 5%. The serum cortisol concentration was higher immediately after surgery than at 3 and 6 days postoperatively in both groups. Weight gain was greater at 3 and 6 days postoperatively in the A group than in the NOA group. Intratesticular local anesthesia before castration in piglets is technically practical, is in accordance with good welfare practice, and improves short-term weight gain in piglets submitted to castration. Key words: Behavior. Castration. Lidocaine. Pig. ResumoO objetivo deste estudo foi investigar o efeito da anestesia local intratesticular prévia à castração sobre o ganho de peso, comportamento e alterações no cortisol de leitões. O delineamento experimental adotado foi inteiramente casualisado. Foram utilizados vinte e nove leitões mestiços Landrace -Large White do sexo masculino com idade de 3 a 6 dias. Os leitões foram divididos aleatoriamente em dois grupos: orquiectomia com anestesia (A, n = 15) e orquiectomia sem anestesia (NOA, n = 14). Aos leitões do grupo A foi administrado 0,5 mL de lidocaína 2% intratesticular com vasoconstritor em cada testículo, e no grupo NOA administrou-se 0,5 mL de NaCl 0,9% intra testicular também em cada testículo. Amostras de sangue foram coletadas de todos os animais imediatamente após a cirurgia e posteriormente aos 3 e 6 dias após a cirurgia para a medição da concentração de cortisol sérico. O comportamento foi avaliado diariamente durante 6 dias por dois observadores que desconheciam o tratamento. O peso foi medido ao mesmo tempo que o cortisol sanguíneo. Foi realizada a análise de variância, e o teste Student-NewmanKeuls para contraste entre médias. O tempo médio de seis avaliações realizadas por 90 minutos durante 6 dias para cada comportamento foi comparado pelo teste de Tukey. O nível de significância estatística foi de 5%. A concentra...

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Section: Discussionmentioning

confidence: 99%

Weight gain, behavioral and cortisol changes after orchiectomy with or without local anaesthesia in piglets

Barticciotto

Luna

Lorena

et al. 2016

SCA

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“…A ropivacaína atenuou a resposta inflamató-ria pulmonar por lipopolissacarídeo em ratos 15 . A lidocaína a 1% e a bupivacaína a 0,5% também foram capazes de prevenir a peritonite provocada por ácido clorídrico a 0,1 M 16 . A ativação da cascata da coagulação tem sido associada ao desenvolvimento da falência de múltiplos órgãos e sistemas, com prognóstico ruim em pacientes sépticos.…”

Section: Discussionunclassified

“…Ropivacaine reduced the pulmonary inflammatory response caused by lipopolysaccharides in mice 15 . Lidocaine, at 1%, and 0.5% bupivacaine demonstrated to be effective on preventing peritonitis induced by 0.1 M of hydrochloric acid when compared with NS 16 . The mortality of mice with septic peritonitis induced according to an experimental model 17 treated with the subcutaneous administration of 5% and 10% lidocaine and 1% and 2% bupivacaine with an infusion pump was reduced and protected against hepatic and renal dysfunctions, by attenuating the hyper-inflammatory response 18 .…”

Section: Introductionmentioning

confidence: 95%

“…A ropivacaína diminuiu a resposta inflamatória pulmonar que foi provocada por lipopolissacarídeo em ratos 15 . A lidocaína a 1% e a bupivacaína a 0,5% mostraram-se eficazes na prevenção da peritonite induzida por ácido clorídrico a 0,1 M, com relação à solução fisiológica a 0,9% 16 . Camundongos com peritonite séptica induzida segundo modelo experimental 17 , tratados com lidocaína a 5% e a 10% e bupivacaína a 1% e a 2%, por via subcutânea, com bomba de infusão, apresentaram diminuição da mortalidade e proteção contra disfunções hepáticas e renais, por atenuar a resposta hiperinflamató-ria 18 .…”

Section: Introductionunclassified

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Efeito da lavagem peritoneal com bupivacaína na sobrevida de ratos com peritonite fecal

Brocco

Paulo

Baptista³

et al. 2008

Rev. Bras. Anestesiol.

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Rev Bras AnestesiolARTIGO CIENTÍFICO 2008; 58: 5: 470-479 SCIENTIFIC ARTICLE RESUMO Brocco MC, Paulo DNS, Baptista JFA, Carraretto AR, Ferrari TA, Azevedo TCV, Silva AL -Efeito da Lavagem Peritoneal com Bupivacaína na Sobrevida de Ratos com Peritonite Fecal. JUSTIFICATIVA E OBJETIVOS:Com base nos conhecimentos sobre a ação antiinflamatória e antibacteriana dos anestésicos locais (AL) o estudo teve como objetivo determinar o efeito da lavagem peritoneal com solução de bupivacaína na sobrevida de ratos com peritonite fecal por fezes autógenas. MÉTODO:Foram utilizados 48 ratos da linhagem Wistar, com peso entre 300 g e 330 g (311,45 ± 9,67), submetidos à laparotomia seis horas após a indução de peritonite, distribuídos aleatoriamente em quatro grupos: 1 -Controle, nenhum tratamento (n = 12); 2 -Enxugamento da cavidade abdominal (n = 12); 3 -Lavagem da cavidade abdominal com 3 mL de solução fisiológica a 0,9% e enxugamento (n = 12); 4 -Lavagem da cavidade abdominal com 8 mg.kg -1 (± 0,5 mL) de bupivacaína 0,5%, adicionada a 2,5 mL de solução fisiológica a 0,9% e enxugamento (n = 12). Os animais que faleceram foram necropsiados e o horário do óbito foi anotado. Os animais sobreviventes foram mortos no 11° dia do pós-operatório e realizou-se a necropsia.RESULTADOS: Houve 100% de mortalidade nos animais do Grupo 1, em 52 horas, 100% nos animais do Grupo 2, em 126 horas e 50% nos animais do Grupo 3 em 50 horas. Os animais do Grupo 4 sobreviveram. A sobrevida, no 11 o dia de pós-operatório, foi maior nos grupos 3 e 4 com relação aos grupos 1 e 2 (p < 0,001) e maior nos Grupo 4 com relação ao Grupo 3 (p < 0,01). CONCLUSÕES:A lavagem peritoneal com solução de bupivacaína diluída em solução fisiológica foi eficaz para evitar o óbito, por 11 dias, em 100% dos animais com peritonite fecal. BACKGROUND AND OBJECTIVES:Based on the knowledge of the anti-inflammatory and anti-bacterial actions of local anesthetics (LA), the objective of this study was to determine the effects of peritoneal lavage with bupivacaine on survival of mice with fecal peritonitis. METHODS:Forty-eight Wistar mice, weighing between 300 and 330 g (311.45 ± 9.67 g), undergoing laparotomy 6 hours after induction of peritonitis were randomly divided in 4 groups: 1 -Control, without treatment (n = 12); 2 -Drying of the abdominal cavity (n = 12); 3 -Lavage with 3 mL NS and posterior drying of the abdominal cavity (n = 12); and 4 -Lavage with 8 mg.kg -1 (± 0.5 mL) of 0.5% bupivacaine added to 2.5 mL of NS followed by drying out of the abdominal cavity (n = 12). Animals that died underwent necropsy and the time of death was recorded. Surviving animals were killed on the 11 th postoperative day and underwent necropsy. RESULTS:Group 1 presented a 100% mortality rate in 52 hours, 100% mortality rate in Group 2 in 126 hours, and Group 3 presented a 50% mortality rate in 50 hours. Animals in Group 4 survived. Survival on the 11 th day was greater in groups 3 and 4 than in Groups 1 and 2 (p < 0.001) and greater in Group 4 than in Group 3 (p < 0.01). CONCLUSIONS:Perit...

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“…Ropivacaine decreased the pulmonary inflammatory response evoked by a lipopolysaccharide in rats 15 . One percent lidocaine and 0.5% bupivacaine were shown to prevent peritonitis caused by 0.1M hydrochloric acid, in comparison with saline 16 . Mice having septic peritonitis induced according to an experimental model 17 , treated with 5% or 10% lidocaine, or 1% or 2% bupivacaíne subcutaneously by an infusion pump, decreased mortality and protected rats from hepatic and renal hepatic dysfunction, by attenuating the hiperinflammatory response 18 .…”

Section: Introductionmentioning

confidence: 95%

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

et al. 2008

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PURPOSE: To study the effects of peritoneal lavage with a 2% lidocaine solution, on the survival of the rats submitted to peritonitis caused by their own feces. METHODS: Forty-eight Wistar rats, weighting between 300g and 330g (mean, 311,45 ±9,67g), were submitted to laparotomy 6 hours following induction of fecal peritonitis. Animals were randomly divided into four groups of 12 each as follows: 1- Control, no therapy; 2- Drying of the abdominal cavity; 3- Peritoneal lavage with saline and drying; 4- Peritoneal lavage with a 2% lidocaine solution and drying. Animals that died were submitted to necropsy and the time of their death recorded; survivors were killed on the post-operation 11th day and necropsied. RESULTS: Death occurred within 52 h in all animals of group 1; within 126 h in 100% of those of group 2; within 50 h in 50% of those of group 3. All animals of group 4 survived. Survival on the 11 th day was higher in groups 3 and 4 than in groups 1 and 2 (p<0.001), and higher in group 4 than in group 3 (p<0.01). CONCLUSION: Peritoneal lavage with a 2% lidocaine saline solution without adrenaline, prevented the mortality of all animals with fecal peritonitis .

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Inhibition of Peritonitis by Amide Local Anesthetics

Cited by 89 publications

References 0 publications

Weight gain, behavioral and cortisol changes after orchiectomy with or without local anaesthesia in piglets

Weight gain, behavioral and cortisol changes after orchiectomy with or without local anaesthesia in piglets

Efeito da lavagem peritoneal com bupivacaína na sobrevida de ratos com peritonite fecal

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

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